The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL16853/0143.
Avloclor® 250 mg Tablets
Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.
1. What Avloclor is and what it is used for
2. What you need to know before you take Avloclor
3. How to take Avloclor
4. Possible side effects
5. How to store Avloclor
6. Contents of the pack and other information
Avloclor contains a medicine called chloroquine phosphate. This belongs to a group of medicines called ‘anti-malarials’.
‘Anti-malarials’ can be taken in certain parts of the world to help prevent malaria. This is a serious disease spread by infected mosquitoes. Avloclor will give some degree of protection (prophylaxis) against malaria in certain countries.
Medicines to help prevent malaria (malaria prophylaxis) are recommended for:
These people have little or no immunity to malaria, so they are at risk of severe attacks.
You must get medical advice on which anti-malarial medicines to take. You must ask your doctor or pharmacist if Avloclor is suitable for the part of the world that you are visiting. In some countries you may have to take Avloclor with another medicine for maximum protection.
When you are taking this medicine to prevent malaria, you should also reduce the chances of being bitten by mosquitoes.
No medicine can be guaranteed to protect against malaria in every case. If you have a high temperature (fever) during your visit to a malaria area, or up to a year after returning home, you should suspect malaria. Contact a doctor straight away and let him or her know that you have visited a malaria area.
Check with your doctor or pharmacist before taking your medicine if:
Chloroquine can cause lowering of the blood glucose level. Please ask your doctor to inform you of signs and symptoms of low blood glucose levels. A check of the blood glucose level may be necessary.
Chloroquine may cause heart rhythm disorders in some patients: caution should be taken when using chloroquine, if you were born with or have family history of prolonged QT interval, if you have acquired QT prolongation (seen on ECG, electrical recording of the heart), if you have heart disorders or have a history of heart attack (myocardial infarction), if you have salt imbalance in the blood (especially low level of potassium or magnesium, see section “Other medicines and Avloclor”).
If you experience palpitations or irregular heart beat during the period of treatment, you should inform your doctor immediately. The risk of heart problems may increase with increase of the dose. Therefore, the recommended dosage should be followed.
Some people being treated with chloroquine can experience mental health problems such as irrational thoughts, hallucinations, feeling confused, aggressiveness, paranoia, feeling depressed or have thoughts of self-harm or suicide, even those who have never had similar problems before. If you or others around, you notice any of these side effects (see section 4) seek medical advice straight away.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Avloclor.
If you go into hospital, tell the medical staff that you are taking Avloclor.
If you live in a country where malaria occurs, you may already be slightly immune to the disease. You must ask a doctor or pharmacist for advice before you take anti-malarial medicines.
Please tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. This includes medicines that you buy without a prescription and herbal medicines.
Amiodarone (used to control heart rate) must not be taken at the same time as Avloclor (see section 2: what you need to know before you take Avloclor).
Tell your doctor or pharmacist if you are taking any of the following medicines. This is because Avloclor may affect the amount of these medicines in your blood.
Also tell your doctor or pharmacist if you are taking any of the following medicines:
Adsorbents and antacid medicines may reduce the amount of Avloclor absorbed from your gut. This may mean that the full dose of Avloclor is not absorbed into your body and it will not work properly. Therefore, you should take these medicines at least four hours before or after taking your Avloclor dose.
Some medicines (for example, ciprofloxacin, cimetidine, omeprazole, pyrimethamine) may increase the amount of Avloclor in your body and this can cause side effects. It is important that you do not take any additional medicines (either prescribed or non-prescribed) before speaking to your doctor.
If you need a vaccination against rabies, make sure you have it before you start your anti-malarial medicine. If you have your rabies injection at the same time as taking your anti-malarial medicine, your rabies vaccine might not work so well.
If you are pregnant or may become pregnant, talk to a doctor or pharmacist:
Sometimes Avloclor causes blurred eyesight or makes it difficult to focus your eyes. If this happens to you, do not drive or use any tools or machines.
Always take Avloclor exactly as described in this leaflet or as your doctor or pharmacist has told you. You should check with your doctor or pharmacist if you are not sure.
Do not give Avloclor to children under 1 year of age. For children over 1 year of age, the dose depends on the child’s age.
If you accidentally take more Avloclor tablets than you should, tell a doctor straight away. The following effects may happen: heart problems – leading to uneven heart beats.
Only stop taking Avloclor four weeks after leaving the malaria area or if your doctor tells you to.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Like all medicines, Avloclor can cause side effects, although not everybody gets them.
If you experience any of the following side effects, stop taking Avloclor and get medical help or contact your doctor straight away.
If you are taking Avloclor for a long time, your doctor may suggest that you have blood tests to check how well your liver is working (rare).
If you develop serious breathlessness or worsening of breathlessness seek prompt medical advice.
When Avloclor is used to prevent or suppress malaria, these are generally not serious. If Avloclor is used for a long time, they can be more serious.
If you are taking Avloclor for a long time, your doctor may suggest that you have eye tests.
Stomach and gut
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the internet at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines that are no longer required. This will help to protect the environment.
Avloclor Tablets are white and round. They have a break line on one side and the letter ‘A’ either side of the line. Avloclor Tablets come in packs of 20 tablets.
The Marketing Authorisation for Avloclor Tablets is held by
Avloclor Tablets are manufactured by
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This leaflet was last revised in April 2022.
© Alliance Pharmaceuticals Limited 2022
Avloclor, Alliance and associated Devices are registered trade marks of Alliance Pharmaceuticals Limited
Avloclor Tablets 250mg PIL UK 008