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Xanax Tablets 250 micrograms & 500 micrograms
Xanax® 250 microgram and 500 microgram Tablets
1. What Xanax is and what it is used for
2. What you need to know before you take Xanax
3. How to take Xanax
4. Possible side effects
5. How to store Xanax
6. Contents of the pack and other information
Xanax contains the active ingredient alprazolam. It belongs to a group of medicines called benzodiazepines (anxiety-relieving medicines).
Xanax is used in adults for treatment of anxiety symptoms which are severe, disabling or causing the patient great distress. This medicine is for short-term use only.
You must talk to a doctor if you do not feel better or if you feel worse.
Talk to your doctor or pharmacist before taking Xanax if you:
Benzodiazepines and related products should be used with caution in elderly, due to the risk of sedation and / or musculoskeletal weakness that can promote falls, often with serious consequences in this population.
Do not give this medicine to children and adolescents below the age of 18 years because safety and efficacy have not been established.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, especially medicines listed below, as the effect of Xanax or the other medicine may change when taken at the same time:
If you are going to have an operation where you will be given a general anaesthetic, tell your doctor or anaesthetist that you are taking Xanax.
Concomitant use of Xanax and opioids (strong pain killers, medicines for substitution therapy and some cough medicines) increases the risk of drowsiness, difficulties in breathing (respiratory depression), coma and may be life-threatening. Because of this, concomitant use should only be considered when other treatment options are not possible. However if your doctor does prescribe Xanax together with opioids the dosage and duration of concomitant treatment should be limited by your doctor. Please tell your doctor about all opioid medicines you are taking, and follow your doctor’s dosage recommendation closely. It could be helpful to inform friends or relatives to be aware of sign and symptoms stated above. Contact your doctor when experiencing such symptoms.
It is important not to drink any alcohol while you are taking Xanax, as alcohol increases the effects of the medicine. Please refer to section 3.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Do not breast-feed while taking Xanax, as the drug may pass into breast milk.
Xanax can make you feel sleepy or woozy and make you lose concentration so it is very important you do not operate machinery until you know how the tablets affect you.
Xanax can affect your ability to drive as it may make you sleepy or dizzy.
Talk to your doctor or pharmacist if you are not sure whether it is safe for you to drive while taking this medicine.
Lactose - If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Sodium Benzoate – this medicine contains 0.11mg Sodium Benzoate in each tablet.
This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free’.
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. Your doctor will tell you how many tablets to take and when to take them. This information is also on the label of the carton the tablets come in.
Do not take your tablets with an alcoholic drink.
The recommended dose is:
You will usually start by taking one 250 microgram or one 500 microgram tablet three times a day. This gives a total dose of 750 micrograms to 1500 micrograms each day.
If clinically required your doctor may increase your medicine in small increments. Where the dose does need to be increased, it is usual to increase the night time dose first, before the daytime doses to make sure you are more alert during the day. If you start to get side effects the doctor may lower your dose.
If you are an older patient or you have for example kidney or liver problems and you need a lower dose you will normally start on a dose of 250 micrograms two or three times a day. This dose may be slowly increased if needed and if you do not get any side effects.
Use in children and adolescents
Alprazolam is not recommended for children and adolescents under the age of 18 years.
For oral use.
The risk of dependency and abuse may increase with the dose and duration of treatment. The doctor will therefore prescribe the lowest effective dose and treatment duration possible, and frequently reassess the need for continued treatment (see section 2 - Warnings and precautions).
The maximum duration of treatment should not be more than 2-4 weeks. Long-term treatment is not recommended.
Your doctor will prescribe the lowest possible effective dose and duration, and will reassess the need for your continued treatment frequently. A decreased effect of the drug may develop if used for more than a few weeks.
It is important that you do not take more tablets than you are told to. If you do accidentally take too many tablets you may experience drowsiness, confusion, feeling cold, slurred speech, drop in blood pressure and difficulty breathing. If you do accidentally take too many tablets, seek medical attention straight away.
If you forget to take a dose, take it as soon as you remember unless it is time for your next dose.
Do not take a double dose to make up for a missed dose.
Always see your doctor before you stop taking Xanax tablets as the dose needs to be reduced gradually. If you stop taking the tablets or reduce the dose suddenly you can get ‘rebound’ effects which might cause you to become temporarily more anxious or restless or to have difficulty sleeping. These symptoms will go away as your body re-adjusts. If you are worried, your doctor can tell you more about this.
Your doctor will therefore reduce the dose gradually when the treatment is ended. Dose reduction is done according to individual needs, since gradual discontinuation depends on several factors (e.g. treatment duration and your daily dose). Ask your doctor about how to reduce your dose gradually.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Like all medicines, this medicine can cause side effects, although not everyone gets them.
If you get any of these symptoms see your doctor straight away as treatment will need to be discontinued. Your doctor will then advise how treatment will be stopped.
Tell your doctor straight away if you get the following symptoms as your dose or treatment might need to be changed:
It is possible to become dependent on medicines like Xanax while you are taking them which increases the likelihood of getting withdrawal symptoms when you stop treatment.
Withdrawal symptoms are more common if you:
This can cause effects such as headaches, muscle pain, extreme anxiety, tension, restlessness, confusion, mood changes, difficulty sleeping and irritability.
In severe cases of withdrawal you can also get the following symptoms: nausea (feeling sick), vomiting, sweating, stomach cramps, muscle cramps, a feeling of unreality or detachment, being unusually sensitive to sound, light or physical contact, numbness and tingling of the feet and hands, hallucinations (seeing or hearing things which are not there while you are awake), tremor or epileptic fits.
Xanax Tablets should only be used by those they are prescribed for. Do not give your medicine to anyone else. Overuse and abuse can lead to overdose and/or death.
Very common: may affect more than 1 in 10 people
Common: may affect up to 1 in 10 people
Uncommon: may affect up to 1 in 100 people
Not known: frequency cannot be estimated from available data
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton and blister strip or bottle after ‘EXP’. The expiry date refers to the last day of that month.
Do not store your tablets above 25°C. Store in the original package in order to protect from moisture.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
The active ingredient is alprazolam.
Each Xanax 250 microgram tablet contains 250 micrograms of the active ingredient alprazolam.
Each Xanax 500 microgram tablet contains 500 micrograms of the active ingredient alprazolam.
The other ingredients are: lactose (section 2 Xanax contains lactose), microcrystalline cellulose, colloidal anhydrous silica, maize starch, magnesium stearate and docusate sodium with sodium benzoate (E 211). The 500 microgram tablets also contain the colour erythrosine sodium aluminium lake.
Xanax 250 microgram tablets are white, oval, biconvex tablets scored on one side and marked ‘Upjohn 29’ on the other. Xanax 500 microgram tablets are pink, oval, biconvex tablets scored on one side and marked ‘Upjohn 55’ on the other. They are available in blister packs of 60 tablets or bottles containing 100 or 1000 tablets. Not all pack sizes may be marketed.
Marketing Authorisation Holder:
This leaflet was last revised in 12/2023.
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