What is a Patient Information Leaflet and why is it useful?

The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged.

Below is a text only representation of the Patient Information Leaflet. The original can be viewed in PDF format using the link above.

The text only version may be available from RNIB in large print, Braille or audio CD. For further information call RNIB Medicine Leaflet Line on 0800 198 5000. The product code(s) for this leaflet is: PL 44374/0011.

Deponit 10

deponit® 10

Transdermal Patch 37.4mg

Glyceryl trinitrate

Package Leaflet: Information for the patient

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet. You may need to read it again
  • If you have further questions, please ask your doctor or pharmacist
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

What is in this leaflet:

1. What Deponit 10 is and what it is used for
2. What you need to know before you use Deponit 10
3. How to use Deponit 10
4. Possible side effects
5. How to store Deponit 10
6. Contents of the pack and other information.

1. What Deponit 10 is and what it is used for

Deponit 10 belongs to a group of medicines called ‘nitrates’. These are used to widen your blood vessels and reduce the workload of your heart.

Deponit 10 is used to prevent angina pectoris. Angina attacks feel like a tight pain in your chest, neck or arm and are a sign that your heart is not getting enough oxygen for the amount of work it is doing.

2. What you need to know before you use Deponit 10

Do not use Deponit 10:

  • If you are allergic to glyceryl trinitrate, to other nitro compounds or to any of the other ingredients of this medicine (listed in section 6)
  • If you are taking medicines for failure to achieve an erection such as Viagra or any other phosphodiesterase inhibitors. Using Deponit 10 with these medicines could cause a severe drop in blood pressure and could lead to collapse and unconsciousness, and may be fatal
  • If you have a condition in which your heart does not pump enough blood around your body due to obstruction of the arteries in the heart as in a condition called aortic or mitral stenosis.
  • If you suffer from a heart condition which is associated with low blood pressure leading to shock.
  • If you suffer from low blood pressure
  • If you suffer from low blood volume
  • If you suffer from anaemia (low iron levels in your blood)
  • If you have an eye disease called glaucoma
  • If you have a heart valve disorder
  • If you suffer from inflammation of the heart lining
  • If you suffer from increased fluid around the heart (cardiac tamponade)
  • If you suffer from a heart condition called hypertrophic obstructive cardiomyopathy
  • If you have ever had a serious head injury, cerebral haemorrhage (bleeding in the brain) or a disease which is accompanied by increased pressure on the brain
  • If you have an acute angina attack. Your doctor will give you a different medicine such as a GTN spray for this.
  • If you are using riociguat, a medicine used in treating pulmonary hypertension

If any of the above applies to you talk to your doctor.

Warnings and precautions

Talk to your doctor or pharmacist before using Deponit 10:

  • If have an underactive thyroid gland
  • If have any diseases of the lungs, liver or kidneys
  • If have recently had a heart attack or you suffer from heart failure
  • If suffer from hypoxaemia (insufficient oxygen in your blood) due to lung disease, heart failure or severe anaemia (low haemoglobin)
  • If have hypothermia (very low body temperature)
  • If are malnourished (severe lack of food).
  • If have a condition called Angina pectoris (chest pain).
  • If have had a heart attack.
  • If have a condition in which there is insufficient blood flow to the brain (cerebral ischemia).

Other medicines and Deponit 10

  • Do not take Deponit 10 with medicines for failure to achieve an erection such as Viagra. Using Deponit 10 with these medicines could cause a severe drop in blood pressure and could lead to collapse and unconsciousness, and may be fatal

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines:

  • Medicines which are used to treat angina, heart failure, or an irregular heartbeat. A blood condition (methaemoglobinaemia) can occur when other nitrate treatments are given at the same time. This can result in breathing problems, anxiety, loss of consciousness and heart attack.
  • Medicines which reduce blood pressure e.g. beta-blockers, calcium channel blockers, vasodilators (e.g. phosphodiesterase inhibitors such as sildenafil), ACE inhibitors, monoamine oxidase inhibitors
  • Diuretics (water tablets)
  • Tricyclic antidepressants (used to treat depression)
  • Neuroleptics (used to treat anxiety)
  • Dihydroergotamine (used to treat migraine)
  • Amifostine (drug used along with anticancer drugs) and Aspirin should not be taken together as they increase the blood pressure lowering effect of Deponit 10.
  • Sapropterine (Tetrahydrobiopterine, BH4)
  • Any other medicine, including medicines obtained without a prescription.

Deponit 10 with alcohol

Do not drink alcohol whilst using Deponit 10 as it can cause your blood pressure to drop.

This may make you may feel dizzy or faint.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or planning to have a baby, ask your doctor for advice before using this medicine.

Driving and using machines

Deponit 10 may make you feel dizzy, tired or have blurred vision. If this happens to you, do not drive a vehicle or operate machinery.

3. How to use Deponit 10

Always use this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.


Your doctor will choose the dose that is right for you. Your dose will be shown clearly on the label that your pharmacist puts on your medicine. If it does not, or you are not sure, ask your doctor or pharmacist.

Use in children

Deponit 10 is not suitable for children.

Adults and the Elderly

  • Normally one patch per day is enough
  • Your doctor may increase this to two patches depending on how you respond to the medicine
  • Each morning put on a new patch
  • Remove the patch before you go to bed
  • You must have 12 hours each day without a patch on. This will prevent you from becoming tolerant to the medicine.

If you do this it will ensure the treatment remains effective.

When applying the patch you should always:

  • Place the new patch on a different area of skin
  • Allow several days to pass before applying a fresh patch to the same area of skin.

Things to remember:

  • Do not stretch the skin when putting a patch on
  • Do not put the patch on a cut or reddened area of skin
  • Do not pull the patch off the skin and then stick it back on again.

How and where to apply the patch

  • Choose a smooth area of skin to apply the patch. The area should be hairless, to ensure good contact of the patch with the skin. The chest, upper abdomen, upper arm, shoulder or thigh is suitable.
  • Your hands and the skin where you will apply the patch should be clean and dry. Do not use powder or moisturiser.
  • Tear open the wrapper across the top, take out the patch and hold it with the writing facing away from you.
  • Fold the patch along the S-shaped cut so the sides of the backing come apart.
  • Hold the patch on one side and peel off the backing on the other side to expose the sticky patch. Place the sticky side of the patch directly onto the skin.
  • Peel off the remainder of the backing and press down firmly with the palm of your hand.

If you use more Deponit 10 than you should

If you accidentally use more Deponit 10 than you should, remove the patches straight away and immediately go to your doctor or the nearest hospital casualty department.

If you use more Deponit 10 than you should, you may have a fall in blood pressure. This may make you feel dizzy, weak and light-headed on standing. You may also be pale, sweat a lot, have a weak pulse, rapid heartbeats (tachycardia), flushed skin, headache, feel sick or be sick, methaemoglobinaemia.

In severe cases of overdose you may get an increase of the pressure of the fluid around the brain.

If you forget to use Deponit 10

  • If you forget to change your patch: Take the old one off and put a new one on as soon as you remember, then carry on as before.
  • If you forget to apply a patch: Put a new one on as soon as possible, then carry on as before.

Do not take a double dose to make up for a forgotten dose.

If you stop using Deponit 10

Do not stop using Deponit 10 even if you feel better. If you stop taking your medicine your condition may get worse. Keep using Deponit 10 until your doctor tells you to stop.

If your doctor thinks you should stop taking Deponit 10 your dose will gradually be reduced.

Also if you are being transferred to another treatment, your dose will be gradually reduced or withdrawn and the overlapping treatment will be started.

4. Possible side effects

Like all medicines, Deponit 10 can cause side effects, although not everybody gets them.

Stop using Deponit and seek immediate medical help if you have an allergic reaction. This includes any of the following symptoms:

  • Sudden wheeziness
  • Difficulties in breathing
  • Swelling of your eyelids, face or lips
  • Rash or itching especially those covering your whole body.

Very common side effects (affects more than 1 in 10 people)

  • Headaches at the start of treatment. These usually disappear after a few days of continuing to use the patches. If necessary you can take mild painkillers e.g. paracetamol.

Common side effects (affects less than 1 in 10 people)

  • Low blood pressure (hypotension) and light-headedness upon standing which you may notice as dizziness, drowsiness, rapid heart beat (reflex tachycardia) and a feeling of weakness at the start of treatment or when the dosage is increased.

Uncommon side effects (affects less than 1 in 100 people)

  • Collapse sometimes with a slow heart beat and fainting
  • Very low blood pressure (severe hypotension) where you are being sick, feeling sick, are restless, have a pale skin and sweat a great deal. This may lead to a worsening of the chest pain you often get with angina
  • Temporary low oxygen level in the blood (temporary hypoxaemia). For people with heart disease this may lead to low oxygen level in the tissue surrounding the heart (myocardial hypoxia)
  • A slight reddening, slight itching or burning sensation on the skin where you have applied the patch. This usually disappears after the patch has been removed. Be sure to put your patch in a different place each day.
  • Allergic skin rash, which may be severe
  • Flushing of the face
  • Feeling sick
  • Being sick
  • Very red skin with scaling and thickened itchy skin (exfoliative dermatitis)
  • Heartburn.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

5. How to store Deponit 10

Keep this medicine out of the sight and reach of children.

Do not use Deponit 10 after the expiry date which is stated on the label. The expiry date refers to the last day of that month.

Store below 25°C.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These medicines will help protect the environment.

6. Contents of the pack and other information

What Deponit 10 contains

The active substance is glyceryl trinitrate. Each transdermal patch contains 37.4 mg of glyceryl trinitrate.

The other ingredients are: acrylate/vinyl acetate copolymer (adhesive matrix); polypropylene (backing foil); and polyethylene (siliconised release liner).

What Deponit 10 looks like and contents of the pack

Deponit 10 is a white, translucent square patch with round corners. It has “Deponit 10” marked on the outer face. Each patch is supplied in a foil pouch. There are 28 patches in a box.

Marketing Authorisation Holder

Merus Labs Luxco II S.à r.l.
26-28, rue Edward Steichen


Aesica Pharmaceuticals GmbH
Alfred-Nobel-Straße 10

This leaflet was last revised in

If this leaflet is difficult to read and you would like it in a different format, please contact

Merus Labs Luxco II S.à r.l.
26-28, rue Edward Steichen