Summary

• Intrathecal, epidural, intraventricular and intracerebral use of tranexamic acid solution for injection is contraindicated.

• Serious, including fatal, adverse reactions have been reported after inadvertent intrathecal administration due to mix-ups, mostly with injectable local anaesthetics.

• Extreme caution should be taken when storing, handling and administering intravenous formulations of tranexamic acid to ensure the correct route of administration. This includes clearly labelling syringes containing tranexamic acid for intravenous use only and storing tranexamic acid injectables separately from injectable local anaesthetics.