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Verapress MR 240 tablets

Active Ingredient:
verapamil hydrochloride
Dexcel Pharma Ltd See contact details
ATC code: 
About Medicine
{healthcare_pro_orange} This information is for use by healthcare professionals
Last updated on emc: 07 Dec 2022
1. Name of the medicinal product

Verapress MR 240 tablets

2. Qualitative and quantitative composition

Verapamil HCI 240.0 mg

Excipient with known effect:

Each modified-release tablet contains about 35 mg sodium.

For a full list of excipients, see section 6.1.

3. Pharmaceutical form

Modified-Release tablets

The score line is only to facilitate breaking for ease of swallowing and not to divide into equal doses.

4. Clinical particulars
4.1 Therapeutic indications

Verapress MR 240 is indicated for the treatment of mild to moderate hypertension, and for the treatment and prophylaxis of angina pectoris.

4.2 Posology and method of administration


Hypertension: Most patients respond to 240 mg daily (one tablet) given as a single dose. If control is not achieved after a period of at least one week the dosage may be increased to a maximum of two Verapress MR 240 tablets daily (one in the morning and one in the evening at an interval of about twelve hours). A further reduction in blood pressure may be achieved by combining Verapress MR 240 with other anti-hypertensive agents, in particular diuretics.

Angina pectoris: One tablet of Verapress MR 240 twice daily. A small number of patients respond to a lower dose and where indicated, adjustment down to one tablet of Verapress MR 240 daily could be made.

Elderly patients: The adult dose is recommended unless renal or hepatic function is impaired (see Section 4.4, 'Special Warnings and Precautions for Use').

The tablets should not be chewed or crushed. They should be swallowed whole with a glass of water.


Verapress MR 240 is not recommended for children.

Liver impairment

In patients with impaired liver function, metabolism of the drug is delayed to a greater or lesser extent depending on the severity of hepatic dysfunction, thus potentiating and prolonging the effects of verapamil hydrochloride. Therefore, the dosage needs to be adjusted with special caution in patients with impaired liver function and low doses should be given initially (see Special Warnings and Precautions for Use Section).

4.3 Contraindications

Hypersensitivity to the active substance or to any of the excipients.

Cardiogenic shock; acute myocardial infarction complicated by bradycardia, marked hypotension, left ventricular failure; second or third degree atrioventricular (AV) block (except in patients with a functioning artificial pacemaker); sino-atrial block; sick sinus syndrome (except in patients with a functioning artificial pacemaker); uncompensated heart failure; bradycardia of less than 50 beats/minute; hypotension of less than 90 mm Hg systolic.

Patients with atrial flutter/fibrillation in the presence of an accessory pathway (e.g. WPW syndrome) may develop increased conduction across the anomalous pathway and ventricular tachycardia may be precipitated.

Combination with ivabradine (see section 4.5 Interactions with other medicinal products and other forms of interaction).

4.4 Special warnings and precautions for use

Since Verapamil is extensively metabolised in the liver, careful dose-titration is required in patients with liver disease. Although the pharmacokinetics of Verapamil in patients with renal impairment are not affected, caution should be exercised and careful patient monitoring is recommended. Verapamil is not removed during dialysis.

Verapamil may affect impulse conduction and should therefore be used with caution in patients with bradycardia or first degree AVblock. Verapamil may affect left ventricular contractility; this effect is small and normally not important but cardiac failure may be precipitated or aggravated. In patients with incipient cardiac failure, therefore, Verapamil should be given only after such cardiac failure has been controlled with appropriate therapy, e.g. digitalis.

When treating hypertension with Verapamil, monitoring of the patient's blood pressure at regular intervals is required.

Caution should be exercised in treatment with HMG CoA reductase inhibitors (e.g., simvastatin, atorvastatin or lovastatin) for patients taking Verapamil. These patients should be started at the lowest possible dose of Verapamil and titrated upwards. If Verapamil treatment is to be added to patients already taking an HMG CoA reductase inhibitor (e.g., simvastatin, atorvastatin or lovastatin), refer to advice in the respective statin product information.

Use with caution in the presence of diseases in which neuromuscular transmission is affected (myasthenia gravis, Lambert-Eaton syndrome, advanced Duchenne muscular dystrophy).


This medicinal product contains about 35 mg sodium per tablet, which is equivalent to 1.75% of the WHO recommended maximum daily intake of 2 g for an adult.

4.5 Interaction with other medicinal products and other forms of interaction

In vitro metabolic studies indicate that Verapamil hydrochloride is metabolized by cytochrome P450 CYP3A4, CYP1A2, CYP2C8, CYP2C9 and CYP2C18. Verapamil has been shown to be an inhibitor of CYP3A4 enzymes and P-glycoprotein (P-gp). Clinically significant interactions have been reported with inhibitors of CYP3A4 causing elevation of plasma levels of Verapamil hydrochloride while inducers of CYP3A4 have caused a lowering of plasma levels of Verapamil hydrochloride, therefore, patients should be monitored for drug interactions.

The following are potential drug interactions associated with Verapamil:

Acetylsalicylic acid

Concomitant use of Verapamil with aspirin may increase the risk of bleeding


Increase in blood alcohol has been reported.

Alpha blockers

Verapamil may increase the plasma concentrations of prazosin and terazosin which may have an additive hypotensive effect.


Verapamil may slightly decrease the plasma clearance of flecainide whereas flecainide has no effect on the Verapamil plasma clearance.

Verapamil may increase the plasma concentrations of quinidine. Pulmonary oedema may occur in patients with hypertrophic cardiomyopathy.

The combination of Verapamil and antiarrhythmic agents may lead to additive cardiovascular effects (e.g. AV block, bradycardia, hypotension, heart failure).


Verapamil may increase the plasma concentrations of carbamazepine. This may produce side effects such as diplopia, headache, ataxia or dizziness. Verapamil may also increase the plasma concentrations of phenytoin.


Verapamil may increase the plasma concentrations of imipramine.


Verapamil may increase the plasma concentrations of glibenclamide (glyburide).

Co-administration of verapamil with metformin may reduce the efficacy of metformin.

Antihypertensives, diuretics, vasodilators

Potentiation of the hypotensive effect.


Rifampicin may reduce the plasma concentrations of Verapamil which may produce a reduced blood pressure lowering effect. Erythromycin, clarithromycin and telithromycin may increase the plasma concentrations of Verapamil.


Verapamil may increase the plasma concentrations of doxorubicin.


Phenobarbital may reduce the plasma concentrations of Verapamil.

Benzodiazepines and other anxiolytics

Verapamil may increase the plasma concentrations of buspirone and midazolam.

Beta blockers

Verapamil may increase the plasma concentrations of metoprolol and propranolol which may lead to additive cardiovascular effects (e.g. AV block, bradycardia, hypotension, heart failure).

Intravenous beta-blockers should not be given to patients under treatment with Verapamil.

Cardiac glycosides

Verapamil may increase the plasma concentrations of digitoxin and digoxin. Verapamil has been shown to increase the serum concentration of digoxin and caution should be exercised with regard to digitalis toxicity. The digitalis level should be determined and the glycoside dose reduced, if required.


Colchicine is a substrate for both CYP3A and the efflux transporter, P-glycoprotein (P-gp). Verapamil is known to inhibit CYP3A and P-gp. When Verapamil and colchicine are administered together, inhibition of P-gp and/or CYP3A by Verapamil may lead to increased exposure to colchicine. Combined use is not recommended.

H2 Receptor antagonists

Cimetidine may increase the plasma concentrations of Verapamil.

HIV antiviral agents

Due to the metabolic inhibitory potential of some of the HIV antiviral agents, such as ritonavir, plasma concentrations of Verapamil may increase. Caution should be used or dose of Verapamil may be decreased.


Verapamil may increase the plasma concentrations of ciclosporin, everolimus, sirolimus and tacrolimus.

Inhaled anaesthetics

When used concomitantly, inhalation anaesthetics and calcium antagonists, such as Verapamil hydrochloride, should each be titrated carefully to avoid additive cardiovascular effects (e.g. AV block, bradycardia, hypotension, heart failure).

Lipid lowering agents

Verapamil may increase the plasma concentrations of atorvastatin, lovastatin and simvastatin.

Treatment with HMG CoA reductase inhibitors (e.g., simvastatin, atorvastatin or lovastatin) in a patient taking Verapamil should be started at the lowest possible dose and titrated upwards. If Verapamil treatment is to be added to patients already taking an HMG CoA reductase inhibitor (e.g., simvastatin, atorvastatin or lovastatin), consider a reduction in the statin dose and retitrate against serum cholesterol concentrations.

Atorvastatin may increase Verapamil levels. Although there is no direct in vivo clinical evidence, there is strong potential for Verapamil to significantly affect atorvastatin pharmacokinetics in a similar manner to simvastatin or lovastatin. Consider using caution when atorvastatin and Verapamil are concomitantly administered.

Fluvastatin, pravastatin and rosuvastatin are not metabolized by CYP3A4 and are less likely to interact with Verapamil.


Serum levels of lithium may be reduced. However, there may be increased sensitivity to lithium causing enhanced neurotoxicity.

Neuromuscular blocking agents employed in anaesthesia

The effects may be potentiated.

Serotonin receptor agonists

Verapamil may increase the plasma concentrations of almotriptan.


Verapamil may increase the plasma concentrations of theophylline.


Sulfinpyrazone may reduce the plasma concentrations of Verapamil which may produce a reduced blood pressure lowering effect.


When oral verapamil was co-administered with dabigatran etexilate (150 mg), a P-gp substrate, the Cmax and AUC of dabigatran were increased but magnitude of this change differs depending on time between administration and the formulation of verapamil. Co-administration of verapamil 240 mg extended-release at the same time as dabigatran etexilate resulted in increased dabigatran exposure (increase of Cmax by about 90% and AUC by about 70%).

Close clinical surveillance is recommended when verapamil is combined with dabigatran etexilate and particularly in the occurrence of bleeding, notably in patients having a mild to moderate renal impairment.

The Risk of bleeding may increase. The Dose of dabigatran with oral verapamil may need to be reduced. (See dabigatran label for dosing instructions).

Other Cardiac therapy

Concomitant use with ivabradine is contraindicated due to the additional heart rate lowering effect of verapamil to ivabradine (see section 4.3).


St. John's Wort may reduce the plasma concentrations of Verapamil, whereas grapefruit juice may increase the plasma concentrations of Verapamil.

4.6 Fertility, pregnancy and lactation

There are no adequate and well-controlled study data in pregnant women. Although animal studies have not shown any teratogenic effects, verapamil should not be given during the first trimester of pregnancy unless, in the clinician's judgement, it is essential for the welfare of the patient.

Verapamil hydrochloride is excreted in human breast milk. Limited human data from oral administration has shown that the infant relative dose of verapamil is low (0.1 – 1% of the mother's oral dose) and that verapamil use may be compatible with breastfeeding. Due to the potential for serious adverse reactions in nursing infants, verapamil should only be used during lactation if it is essential for the welfare of the mother.

4.7 Effects on ability to drive and use machines

Depending on individual susceptibility, the patients' ability to drive a vehicle, operate machinery or work under hazardous conditions may be impaired. This is particularly true in the initial stages of treatment, when changing over from another drug or when the dose is raised. Like many other common medicines, Verapamil has been shown to increase the blood levels of alcohol and slow its elimination. Therefore the effects of alcohol may be exaggerated.

4.8 Undesirable effects

Reactions from Postmarketing Surveillance or Phase IV Clinical Trials

The following adverse events reported with Verapamil are listed below by system organ class:

Immune system disorders: allergic reactions (e.g. erythema, pruritus, urticaria) are very rarely seen.

Nervous system disorders: headache, dizziness, paresthesia, tremor and extrapyramidal syndrome.

Ear and labyrinth disorders: vertigo and tinnitus.

Cardiac disorders/vascular disorders: bradycardic arrhythmias such as sinus bradycardia, sinus arrest with asystole, 2nd and 3rd degree AV block, bradyarrhythmia in atrial fibrillation, peripheral oedema, palpitations, tachycardia, development or aggravation of heart failure and hypotension. There have been rare reports of flushing.

Gastrointestinal disorders: nausea, vomiting, constipation, ileus and abdominal pain/discomfort. Gingival hyperplasia may occur very rarely when the drug is administered over prolonged periods, and is fully reversible when the drug is discontinued.

Skin and subcutaneous tissue disorders: ankle oedema, Quincke's oedema, Steven-Johnson syndrome, erythema multiforme, erythromelalgia, alopecia and purpura.

Musculoskeletal and connective tissue disorders: muscular weakness, myalgia and arthralgia.

Reproductive system and breast disorders: impotence (erectile dysfunction) has been rarely reported and isolated cases of galactorrhoea. On very rare occasions, gynaecomastia has been observed in elderly male patients under long-term Verapamil treatment, and is fully reversible in all cases when the drug was discontinued.

General disorders and administration site conditions: fatigue.

Investigations: A reversible impairment of liver function characterized by an increase of transaminase and/or alkaline phosphatase may occur on very rare occasions during Verapamil treatment and is most probably a hypersensitivity reaction. Rises in blood prolactin levels have been reported.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme Website: or search for MHRA Yellow Card in the Google Play or Apple App Store

4.9 Overdose

The course of symptoms in Verapamil intoxication depends on the amount taken, the point in time at which detoxication measures are taken and myocardial contractility (age related). The main symptoms are as follows: acute respiratory distress syndrome, blood pressure fall (at times to values not detectable), shock symptoms, loss of consciousness, 1st and 2nd degree AV block (frequently as Wenckebach's Phenomenon with or without escape rhythms), total AV block with total AV dissociation, escape rhythm, asystole, bradycardia up to high degree AV block and sinus arrest, hyperglycaemia, stupor and metabolic acidosis. Fatalities have occurred as a result of overdose.

The therapeutic measures to be taken depend on the point in time at which Verapamil was taken and the type and severity of intoxication symptoms. In intoxications with large amounts of slow-release preparations, it should be noted that the release of the active drug and the absorption in the intestine may take more than 48 hours. Verapamil hydrochloride cannot be removed by haemodialysis. Depending on the time of ingestion, it should be taken into account that there may be some lumps of incompletely dissolved tablets along the entire length of the gastro-intestinal tract, which function as active drug depots.

General measures to be taken: gastric lavage with the usual precautions, even later than 12 hours after ingestion, if no gastro-intestinal motility (peristaltic sounds) is detectable. Where intoxication by Verapamil 240 MR is suspected, extensive elimination measures are indicated, such as induced vomiting, removal of the content of the stomach and the small intestine under endoscopy, intestinal lavage, laxative, high enemas. The usual intensive resuscitation measures apply, such as extrathoracic heart massage, respiration, defibrillation and/or pacemaker therapy.

Specific measures to be taken: elimination of cardiodepressive effects, hypotension or bradycardia. The specific antidote is calcium, e.g. 10-20 ml of a 10% calcium gluconate solution administered intravenously (2.25-4.5 mmol) repeated if necessary or given as a continuous drip infusion (e.g. 5 mmol/hour).

The following measures may also be necessary: in case of 2nd or 3rd degree AV block, sinus bradycardia, asystole: atropine, isoprenaline, orciprenaline or pacemaker therapy. In case of hypotension: dopamine, dobutamine, noradrenaline. If there are signs of continuing myocardial failure: dopamine, dobutamide, if necessary repeated calcium injections.

5. Pharmacological properties
5.1 Pharmacodynamic properties

Pharmacotherapeutic group: Selective calcium channel blockers with direct cardiac effects, phenylalkylamine derivatives.

ATC-Code: C08DA01

Verapamil, a phenylalkylamine calcium antagonist, has a balanced profile of cardiac and peripheral effects. It lowers heart rate, increases myocardial perfusion and reduces coronary spasm. In a clinical study in patients after myocardial infarction, Verapamil reduced total mortality, sudden cardiac death and reinfarction rate.

Verapamil reduces total peripheral resistance and lowers high blood pressure by vasodilation, without reflex tachycardia. Because of its user-dependent action on the voltage-operated calcium channel, the effects of Verapamil are more pronounced on high than on normal blood pressure.

As early as day one of treatment, blood pressure falls; the effect is found to persist also in long term therapy. Verapamil is suitable for the treatment of all types of hypertension: for monotherapy in mild to moderate hypertension; combined with other antihypertensives (in particular with diuretics and, according to more recent findings, with ACE inhibitors) in more severe types of hypertension. In hypertensive diabetic patients with nephropathy, Verapamil in combination with ACE inhibitors led to a marked reduction of albuminuria and to an improvement of creatinine clearance.

5.2 Pharmacokinetic properties

Absorption: More than 90% of an orally-administered dose of Verapamil is absorbed. Due to an intensive hepatic first-pass metabolism, the absolute bioavailability is about 22% with a variability of about 10 - 35%. Under multiple dosing, bioavailability increases by about 30%. Bioavailability is not affected by food consumption.

Distribution, biotransformation and elimination: Plasma concentrations reach their peak 4 - 8 hours after drug intake. Plasma protein binding of Verapamil is about 90%. The elimination half-life is about 5 - 8 hours. The mean residence time of modified-release Verapamil is 18 hours. After repeated single daily doses, steady-state conditions are reached between 3 - 4 days.

Within 5 days, approximately 70% of an orally-administered dose is excreted in the urine and about 16% with the faeces. Only 3 - 4 % is eliminated renally as unchanged drug. The drug is extensively metabolized. A number of metabolites are generated in humans (twelve have been identified). Of these metabolites only norverapamil has any appreciable pharmacological effect (approximately 20% that of the parent compound, which was observed in a study with dogs). Norverapamil represents about 6% of the dose eliminated in urine. Norverapamil can reach steady-state plasma concentrations approximately equal to those of Verapamil itself. Renal insufficiency does not affect the kinetics of Verapamil.

Special Populations


Aging may affect the pharmacokinetics of verapamil given to hypertensive patients. Elimination half-life may be prolonged in the elderly. The antihypertensive effect of verapamil was found not to be age-related.

Renal insufficiency:

Impaired renal function has no effect on verapamil pharmacokinetics, as shown by comparative studies in patients with end-stage renal failure and subjects with healthy kidneys. Verapamil and norverapamil are not significantly removed by hemodialysis.

Hepatic insufficiency:

The half-life of verapamil is prolonged in patients with impaired liver function owing to lower oral clearance and a higher volume of distribution.

5.3 Preclinical safety data

Reproduction studies have been performed in rabbits and rats at oral verapamil doses up to 0.6 (180 mg/m2/day) and 1.2 times (360 mg/m2/day) respectively the equivalent maximum recommended human oral daily dose of 300mg/m2/day) and have revealed no evidence of teratogenicity. In the rat, the highest dose was embryocidal and retarded fetal growth and development. These effects occurred in the presence of maternal toxicity (reflected by reduced food consumption and reduced weight gain of dams). This oral dose has also been shown to cause hypotension in rats.

6. Pharmaceutical particulars
6.1 List of excipients

Sodium alginate, Microcrystalline cellulose, Povidone, Hypromellose 2208, Colloidal anhydrous silica, Magnesium stearate.

Film coating constituents: Hypromellose 2910, Titanium dioxide, Macrogol 400, D&C Yellow No. 10 Aluminium Lake E-104, Indigo Carmine Aluminium Lake E-132 FD&C Blue No. 2, Carnauba wax.

6.2 Incompatibilities


6.3 Shelf life

5 years

6.4 Special precautions for storage

Do not store above 25° C.

Store in the original package in order to protect from moisture.

6.5 Nature and contents of container

Blister pack: PVDC-coated-PVC/Aluminium foil.

28 tablets

6.6 Special precautions for disposal and other handling

No special requirements.

Any unused medicinal product or waste material should be disposed of in accordance with local requirements.

7. Marketing authorisation holder

Dexcel-Pharma Ltd,

7 Sopwith Way

Drayton Fields

Daventry, Northamptonshire NN11 8PB

United Kingdom

8. Marketing authorisation number(s)

PL 14017/0004

9. Date of first authorisation/renewal of the authorisation

19 March 1997 / 09 July 2002

10. Date of revision of the text


Dexcel Pharma Ltd
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7, Sopwith Way, Drayton Fields, Daventry, Northamptonshire, NN11 8PB, UK
+44 (0)1327 312 266
+44 (0)1327 312 262
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