The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet are: PL 16950/0010, PL 16950/0121, PL 16950/0011, PL 16950/0012, PL 16950/0013.
Adizem®-XL 120 mg, 180 mg, 200 mg, 240 mg and 300 mg prolonged release capsules
1. What Adizem-XL capsules are and what they are used for
2. What you need to know before you take Adizem-XL capsules
3. How to take Adizem-XL capsules
4. Possible side effects
5. How to store Adizem-XL capsules
6. Contents of the pack and other information
These capsules have been prescribed for you to treat angina (chest pain caused by a reduction of oxygen to the heart muscle) or high blood pressure (hypertension). They contain the active ingredient diltiazem. Diltiazem belongs to a group of medicines called calcium antagonists. Calcium antagonists help more blood to reach the heart and reduce blood pressure. The other ingredients of Adizem-XL capsules are listed in section 6 of this leaflet.
Adizem-XL capsules are designed to work properly over 24 hours. If the capsules are crushed or chewed, the entire 24-hour dose may be absorbed rapidly into your body. This can be dangerous, causing serious problems such as an overdose.
Children should not take these capsules.
Talk to your doctor or pharmacist before taking these capsules if you:
Please tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription. If you take Adizem-XL capsules with some other medicines, the effect of Adizem-XL capsules or the other medicine may be changed.
In particular, do not take this medicine and tell your doctor if you are taking:
Tell your doctor or pharmacist if you are taking:
If you are having a general anaesthetic, tell your doctor that you are taking these capsules as some of the effects of the anaesthetic may be increased by these capsules.
Do not take Adizem-XL capsules at the same time as an alcoholic drink.
Do not take Adizem-XL capsules if you are pregnant, likely to become pregnant or are breastfeeding.
Ask your doctor or pharmacist for advice before taking any medicine.
The capsules may cause a number of side effects such as dizziness and a general feeling of being unwell. These could affect your ability to drive (see section 4 for a full list of side effects) and are usually most noticeable when you start taking the capsules, or when changing to higher dose. If you are affected you should not drive or operate machinery.
If you are allergic to peanuts or soya do not take these capsules.
This medicine contains less than 1mmol sodium (23mg) per capsule, that is to say essentially ‘sodium-free’.
Always take Adizem-XL capsules exactly as your doctor has told you. The label on your medicine will tell you how many capsules to take and how often.
The usual starting dose for adults is one 240 mg capsule every 24 hours. However, if you are elderly or have kidney problems then your doctor will probably suggest a lower starting dose of one 120 mg capsule every 24 hours. Your doctor will decide how many capsules you should take.
Children should not take these capsules.
Do not exceed the dose recommended by your doctor. You should check with your doctor or pharmacist if you are not sure.
Swallow your capsules whole with a glass of water. Do not chew or crush the capsules.
Adizem-XL capsules are designed to work properly over 24 hours when swallowed whole. If a capsule is broken, crushed, dissolved or chewed, the entire 24-hour dose may be absorbed rapidly into your body. This can be dangerous, causing serious problems such as overdose.
You should take your capsules every 24 hours. For instance, if you take a capsule at 8 o’clock in the morning, you should take your next capsule at 8 o’clock the next morning.
Call your doctor or hospital immediately. People who have taken an overdose may become very unwell and the following effects may happen: feel faint, have a slow heart beat, decrease of kidney function and lose consciousness. They may need emergency treatment in hospital. When seeking medical attention make sure that you take this leaflet and any remaining capsules with you to show to the doctor.
If you remember within 4 hours of the time your capsule was due, take your capsule straight away. Take your next capsule at your normal time. If you are more than 4 hours late, please call your doctor or pharmacist for advice. Do not take a double dose to make up for a forgotten capsule.
You should not stop taking these capsules unless your doctor tells you to. If you want to stop taking your capsules, discuss this with your doctor first.
If you have any further questions on the use of Adizem-XL capsules ask your doctor or pharmacist.
Like all medicines, Adizem-XL capsules can cause side effects, although not everybody gets them.
Look out for the following severe reactions. They have occurred in a small number of people, although their exact frequency cannot be estimated:
Tell your doctor immediately if you get any of these.
Very common side effects (May affect more than 1 in 10 people)
Common side effects (May affect up to 1 in 10 people)
Uncommon side effects (May affect up to 1 in 100 people)
Rare side effects (May affect up to 1 in 1000 people)
Frequency not known (frequency cannot be estimated from the available data)
You may see the remains of the capsules in your faeces. This should not affect how the capsules work.
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine
Keep out of the sight and reach of children.
Do not use any capsules after the expiry date which is stated on the blister and carton after EXP. The expiry date refers to the last day of that month.
Do not store your capsules above 25ºC.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.
The active ingredient is diltiazem hydrochloride. Each capsule contains 120 mg, 180 mg, 200 mg, 240 mg or 300 mg of diltiazem hydrochloride.
The other ingredients are microcrystalline cellulose, ethylcellulose, colloidal anhydrous silica, Polysorbate 80, dibutyl sebacate, magnesium stearate, sodium dodecyl sulphate, gelatin, shellac, soya lecithin, 2-ethoxyethanol, dimeticone, iron oxide (E172), titanium dioxide (E171).
The capsules also contain the following colourants:
120 mg, 180 mg and 240 mg – erythrosine (E127) and indigo carmine (E132)
300 mg - erythrosine (E127), indigo carmine (E132) and patent blue V (E131)
Adizem-XL capsules are marked DCR followed by the strength (e.g. 120, 180 etc.) and are coloured as follows: 120 mg - pale pink/navy blue, 180 mg - dark pink/royal blue, 200 mg - brown, 240 mg - dark red/blue, 300 mg - dark maroon/pale blue.
The capsules are packed in blister packs and then placed in boxes. In each box there are 28 capsules.
This leaflet is also available in large print, Braille or as an audio CD. To request a copy, please call the RNIB Medicine Information line (free of charge) on:
0800 198 5000
You will need to give details of the product name and reference number.
These are as follows:
Product name: Adizem-XL prolonged-release capsules
Reference number: 16950/0010
This leaflet was last revised in June 2023
® Adizem and the NAPP logo are registered trademarks.
© 2009-2023 Napp Pharmaceuticals Limited.