Active ingredient
- clobazam
Legal Category
POM: Prescription only medicine
POM: Prescription only medicine
The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged.
Below is a text only representation of the Patient Information Leaflet. The original leaflet can be viewed using the link above.
The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL00427/0227.
Perizam 1mg/ml Oral Suspension
Package leaflet: Information for the user
Perizam 1mg/ml Oral Suspension
Clobazam
Read all of this leaflet carefully before you start taking this medicine - because it contains important information for you.
What is in this leaflet:
1. What Perizam Oral Suspension is and what it is used for
2. What you need to know before you take Perizam Oral Suspension
3. How to take Perizam Oral Suspension
4. Possible side effects
5. How to store Perizam Oral Suspension
6. Contents of the pack and other information
1. What Perizam Oral Suspension is and what it is used for
The full name of your medicine is Perizam 1mg/ml Oral Suspension. In this leaflet the shorter name Perizam is used. It contains the active ingredient Clobazam.
Perizam belongs to a group of medicines called ‘benzodiazepines’. It works by having a calming effect on the brain.
Perizam can be used for:
2. What you need to know before you take Perizam Oral Suspension
Do not take Perizam if:
Do not take this medicine if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Perizam.
Warnings and precautions
Note: Make sure that you receive the same clobazam medicine every time you collect your prescription unless your doctor has agreed to change to a different clobazam medicine. If the appearance of this medicine is not the same as usual or if the dosage instructions have changed, speak to your doctor or pharmacist as soon as possible to make sure you have the right medicine.
There have been very rare reports of potentially life-threatening skin rashes (Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis) with the use of Perizam. Symptoms of which may include: flu-like symptoms followed by a painful red or purplish rash that spreads and blisters. If you develop any of the above you must stop taking this medicine and inform your doctor straight away (see Section 4).
Talk to your doctor or pharmacist before taking Perizam if:
Drowsiness, difficulties breathing, coma and death may occur if Perizam is taken together with opioids. Perizam and opioids should only be used concomitantly, when other treatment options are inadequate. Please tell your doctor about all opioid medicines you are taking and follow your doctor’s dosage recommendations closely.
If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking Perizam.
Suicidal thoughts
Tell your doctor straight away if you start thinking about suicide or harming yourself. Some patients have had suicidal thoughts while taking medicines containing clobazam, especially if they were also depressed.
Dependence, withdrawal and tolerance
You may become dependent on Perizam if you take it for a long period of time, especially if you regularly drink a lot of alcohol or use drugs. This means that you may feel that you need to continue the treatment with Perizam in order to feel well (‘psychological dependence’).
If you suddenly stop taking Perizam you may get:
These are known as ‘withdrawal symptoms’ and can be avoided by slowly reducing your dose. Talk to your doctor or pharmacist if you are worried about ‘psychological dependence’ or ‘withdrawal symptoms’.
If you take Perizam for epilepsy for a long period of time then it is possible that you may become ‘tolerant’ to it. This means that it will not work as well as it did when you first started taking it. Talk to your doctor if you feel that Perizam is no longer helping to control your symptoms - they may suggest that you take a short break from this medicine.
Children under 2 years
Epilepsy (fits): Perizam should only be taken by children under 2 years if the doctor decides this is necessary.
Other medicines and Perizam
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes medicines obtained without a prescription and herbal medicines. This is because Perizam can affect the way some other medicines work.
Also, some other medicines can affect the way Perizam works.
In particular tell your doctor or pharmacist if you are taking any of the following:
When taking Perizam you should not start taking any different medicines containing clobazam unless your doctor tells you to. If you do, it may cause breathing difficulties and sleepiness.
Concomitant use of Perizam and opioids increases the risk of drowsiness, difficulties breathing, coma and death. Follow your doctor’s dosage recommendations closely.
If you are not sure if any of the above apply to you talk to your doctor or pharmacist.
Operations
If you are going to have an operation or dental work, tell your doctor or dentist that you are taking Perizam. This is because they may need to change the amount of medicine (anaesthetic or muscle relaxant) they give to you.
Perizam with alcohol
Do not drink alcohol while taking Perizam. This is because alcohol can change the way Perizam works.
Pregnancy, breast-feeding and fertility
Do not take Perizam if:
Talk to your doctor before taking this medicine if you are more than 3 months pregnant or plan to become pregnant.
In fertility studies, no effects on fertility were observed in animals.
Driving and using machines
You may feel sleepy or have concentration or memory problems after taking this medicine. You may also experience double vision or you may react more slowly to things. If this happens, do not drive or use any tools or machines.
The medicine can affect your ability to drive as it may make you feel sleepy or dizzy.
Talk to your doctor or pharmacist if you are not sure whether it is safe for you to drive while taking this medicine.
Perizam contains liquid maltitol, sodium methyl and sodium propyl parahydroxybenzoate, sodium and propylene glycol.
3. How to take Perizam Oral Suspension
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
Perizam is usually given for 2 to 4 weeks. After that your doctor will decide whether you should keep taking this medicine.
Taking this medicine
Measuring your dose
Instructions for use of the syringe.
If you are taking a large dose, you may have to measure the dose with the syringe more than one time. It may be helpful to write on a piece of paper the amount of times you have to use the syringe. Each time you take the dose, tick off a dose on the paper.
How much to take
If low doses are required, the 1mg/ml strength product is the most suitable presentation.
If high doses are required, the 2mg/ml strength product is the most suitable presentation.
Adults
Children (2 years and over)
Elderly
If you take more Perizam than you should
If you forget to take Perizam
If you stop taking Perizam
Keep taking this medicine until your doctor tells you to stop. Do not stop taking this medicine just because you feel better.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effects may happen with this medicine:
Stop taking Perizam and see a doctor or go to a hospital straight away if you notice the following serious side effect - you may need urgent medical treatment:
Stop taking Perizam and see a doctor or go to a hospital straight away if you notice the symptoms listed above.
Tell your doctor straight away if you have any of the following side effects:
Common side effects (may affect up to 1 in 10 people:
Uncommon side effects (may affect up to 1 in 100 people):
Not known (frequency cannot be estimated from available data):
If you get any of the above side effects, your doctor may decide that your treatment needs to be stopped. These side-effects are more likely to happen in elderly people and children.
Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet.
Very common side effects (may affect more than 1 in 10 people):
Common side effects (may affect up to 1 in 10 people):
Uncommon side effects (may affect up to 1 in 100 people):
Not known (frequency cannot be estimated from available data):
If you take this medicine for a long time, you are more likely to get the following side effects: anxiety, confusion, depression, loss of appetite and difficulty sleeping.
Use of Perizam may lead to a physical addiction. Stopping Perizam suddenly may lead to side effects. Dependence on Perizam may occur. Talk to your doctor if you feel you have developed a dependence on Perizam.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly (see details below). By reporting side effects you can help provide more information on the safety of this medicine.
United Kingdom
or search for MHRA Yellow Card in the Google Play or Apple App Store.
5. How to store Perizam Oral Suspension
6. Contents of the pack and other information
What Perizam contains
What Perizam looks like and contents of the pack
Perizam is an off-white suspension. It comes in a brown glass bottle holding 150ml of suspension with a 5ml syringe and bottle adaptor. The bottle adaptor is not pre-fitted.
The Marketing Authorisation Holder and Manufacturer is
This medicinal product is authorised in the Member States of the EEA under the following names:
UK Perizam 1mg/ml Oral Suspension
Ireland Perizam 1mg/ml Oral Suspension
France Likozam 1 mg/ml suspension buvable
This leaflet was last revised in 10/2020.
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