The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet are: PL 17901/0243, PL 17901/0201, PL 17901/0203, PL 17901/0202.
Crestor 5mg, 10mg, 20mg and 40mg film-coated tablets
Crestor® 5 mg film-coated tablets
Crestor® 10 mg film-coated tablets
Crestor® 20 mg film-coated tablets
Crestor® 40 mg film-coated tablets
1) What Crestor is and what it is used for
2) What you need to know before you take Crestor
3) How to take Crestor
4) Possible side effects
5) How to store Crestor
6) Contents of the pack and other information
Crestor belongs to a group of medicines called statins.
You have been prescribed Crestor because:
Heart attack, stroke and other problems can be caused by a disease called atherosclerosis. Atherosclerosis is due to build-up of fatty deposits in your arteries.
Crestor is used to correct the levels of fatty substances in the blood called lipids, the most common of which is cholesterol.
There are different types of cholesterol found in the blood – ‘bad’ cholesterol (LDL-C) and ‘good’ cholesterol (HDL-C).
For most people, high cholesterol does not affect the way they feel because it does not produce any symptoms. However, if it is left untreated, fatty deposits can build up in the walls of your blood vessels causing them to narrow.
Sometimes, these narrowed blood vessels can get blocked which can cut off the blood supply to the heart or brain leading to a heart attack or a stroke. By lowering your cholesterol levels, you can reduce your risk of having a heart attack, a stroke or related health problems.
You need to keep taking Crestor, even if it has got your cholesterol to the right level, because it prevents your cholesterol levels from creeping up again and causing build-up of fatty deposits. However, you should stop if your doctor tells you to do so, or you have become pregnant.
Do not take Crestor:
If any of the above applies to you (or you are in doubt), please go back and see your doctor.
In addition, do not take Crestor 40 mg (the highest dose):
If any of the above applies to you (or you are in doubt), please go back and see your doctor.
Talk to your doctor or pharmacist before taking Crestor.
If any of the above applies to you (or if you are not sure):
Serious skin reactions including Stevens-Johnson syndrome and drug reaction with eosinophilia and systemic symptoms (DRESS) have been reported in association with Crestor treatment. Stop using Crestor and seek medical attention immediately if you notice any of the symptoms described in section 4.
In a small number of people, statins can affect the liver. This is identified by a simple test which looks for increased levels of liver enzymes in the blood. For this reason, your doctor will usually carry out this blood test (liver function test) before and during treatment with Crestor.
While you are on this medicine your doctor will monitor you closely if you have diabetes or are at risk of developing diabetes. You are likely to be at risk of developing diabetes if you have high levels of sugars and fats in your blood, are overweight and have high blood pressure.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines
Tell your doctor if you are taking any of the following:
The effects of these medicines could be changed by Crestor or they could change the effect of Crestor.
If you need to take oral fusidic acid to treat a bacterial infection you will need to temporarily stop using this medicine. Your doctor will tell you when it is safe to restart Crestor. Taking Crestor with fusidic acid may rarely lead to muscle weakness, tenderness or pain (rhabdomyolysis). See more information regarding rhabdomyolysis in Section 4.
Do not take Crestor if you are pregnant or breast-feeding. If you become pregnant while taking Crestor stop taking it immediately and tell your doctor. Women should avoid becoming pregnant while taking Crestor by using suitable contraception.
Ask your doctor or pharmacist for advice before taking any medicine.
Most people can drive a car and operate machinery while using Crestor – it will not affect their ability. However, some people feel dizzy during treatment with Crestor. If you feel dizzy, consult your doctor before attempting to drive or use machines.
Crestor contains lactose.
If you have been told by your doctor that you have an intolerance to some sugars (lactose or milk sugar), contact your doctor before taking Crestor.
For a full list of ingredients, please see Contents of the pack and other information.
Always take this medicine as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
If you are taking Crestor for high cholesterol:
Your treatment with Crestor must start with the 5 mg or the 10 mg dose, even if you have taken a higher dose of a different statin before. The choice of your start dose will depend upon:
Please check with your doctor or pharmacist which start dose of Crestor will best suit you.
Your doctor may decide to give you the lowest dose (5 mg) if:
Your doctor may decide to increase your dose. This is so that you are taking the amount of Crestor that is right for you. If you started with a 5 mg dose, your doctor may decide to double this to 10 mg, then 20 mg and then 40 mg if necessary. If you started on 10 mg, your doctor may decide to double this to 20 mg and then 40 mg if necessary. There will be a gap of four weeks between every dose adjustment.
The maximum daily dose of Crestor is 40 mg. It is only for patients with high cholesterol levels and a high risk of heart attacks or stroke whose cholesterol levels are not lowered enough with 20 mg.
If you are taking Crestor to reduce your risk of having a heart attack, stroke or related health problems:
The recommended dose is 20 mg daily. However, your doctor may decide to use a lower dose if you have any of the factors mentioned above.
The dose range in children and adolescents aged 6 to 17 years is 5 to 20 mg once daily. The usual start dose is 5 mg per day, and your doctor may gradually increase your dose to find the right amount of Crestor for you. The maximum daily dose of Crestor is 10 or 20 mg for children aged 6 to 17 years depending on your underlying condition being treated. Take your dose once a day. Crestor 40 mg tablet should not be used by children.
Swallow each tablet whole with a drink of water.
Take Crestor once daily. You can take it at any time of the day with or without food.
Try to take your tablet at the same time every day to help you to remember it.
It is important to go back to your doctor for regular cholesterol checks, to make sure your cholesterol has reached and is staying at the correct level.
Your doctor may decide to increase your dose so that you are taking the amount of Crestor that is right for you.
Contact your doctor or nearest hospital for advice.
If you go into hospital or receive treatment for another condition, tell the medical staff that you’re taking Crestor.
Don’t worry, just take your next scheduled dose at the correct time. Do not take a double dose to make up for a forgotten dose.
Talk to your doctor if you want to stop taking Crestor. Your cholesterol levels might increase again if you stop taking Crestor.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
It is important that you are aware of what these side effects may be. They are usually mild and disappear after a short time.
Stop taking Crestor and seek medical help immediately if you have any of the following allergic reactions:
Also, stop taking Crestor and talk to your doctor immediately:
Common possible side effects (these may affect between 1 in 10 and 1 in 100 patients):
Uncommon possible side effects (these may affect between 1 in 100 and 1 in 1,000 patients):
Rare possible side effects (these may affect between 1 in 1,000 and 1 in 10,000 patients):
Very rare possible side effects (these may affect less than 1 in 10,000 patients):
Side effects of unknown frequency may include:
If you get any side effects talk to your doctor or pharmacist. This includes any side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
The active substance in Crestor is rosuvastatin. Crestor film-coated tablets contain rosuvastatin calcium equivalent to 5 mg, 10 mg, 20 mg or 40 mg of rosuvastatin. The other ingredients are: lactose monohydrate, microcrystalline cellulose, calcium phosphate, crospovidone, magnesium stearate, hypromellose, triacetin, titanium dioxide (E171). Crestor 10 mg, 20 mg and 40 mg film-coated tablets also contain red iron oxide (E172). Crestor 5 mg film-coated tablets also contain yellow iron oxide (E172).
Crestor comes in blister packs containing 7, 14, 15, 20, 28, 30, 42, 50, 56, 60, 84, 90, 98 and 100 tablets and plastic containers with 30 and 100 tablets (Not all packs are available in every country).
Crestor comes in four tablet strengths:
Crestor 5 mg film-coated tablets are yellow, round and marked with ZD4522 and 5 on one side and plain on the reverse.
Crestor 10 mg film-coated tablets are pink, round and marked with ZD4522 and 10 on one side and plain on the reverse.
Crestor 20 mg film-coated tablets are pink, round and marked with ZD4522 and 20 on one side and plain on the reverse.
Crestor 40 mg film-coated tablets are pink, oval and marked with ZD4522 on one side and 40 on the reverse.
The Marketing Authorisations for Crestor are held by
Manufacturers responsible for batch release:
This product is authorised in the Member States of the EEA under the following name(s):
Crestor 5 mg, 10 mg, 20 mg and 40 mg (NL, AT, BE, DK, GR, FI, IC, IE, IT, LU, NO, MT, PL, PT, SE, UK), and 5 mg, 10 mg and 20 mg (DE, ES, FR).
To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge:
0800 198 5000 (UK only)
Please be ready to give the following information:
Product name Reference number
Crestor 5 mg Film-coated Tablets 17901/0243
Crestor 10 mg Film-coated Tablets 17901/0201
Crestor 20 mg Film-coated Tablets 17901/0202
Crestor 40 mg Film-coated Tablets 17901/0203
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This leaflet was last revised in February 2023
CV 23 0021
For more information about Cholesterol and health contact HEART UK The Cholesterol Charity
HEART UK Cholesterol Helpline
T: 0345 450 5988 Monday–Friday 10am–3pm
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