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400 micrograms per metered dose, Sublingual spray
1. What Glytrin is and what it is used for
2. What you need to know before you use Glytrin
3. How to use Glytrin
4. Possible side effects
5. How to store Glytrin
6. Contents of the pack and other information
Your medicine is called Glytrin.
It is a sublingual (under the tongue) aerosol spray that contains the active ingredient glyceryl trinitrate. Glyceryl trinitrate belongs to a group of medicines called nitrates that relax the muscle walls of the blood vessels and reduce the workload of the heart.
Glytrin is used to treat angina at the onset of an attack. It is also used for the prevention of angina, which can be brought on from physical effort, emotional stress, and exposure to cold, etc.
Talk to your doctor before using Glytrin if any of the following apply to you:
Please consult your doctor, even if these statements were applicable to you at any time in the past. You may need to be more closely supervised during treatment.
Do not give this medicine to children and adolescents under 18 years.
Tell your doctor if you are taking, have recently taken or might take any other medicines.
Be careful about drinking alcohol as Glytrin may affect you more than usual. Both alcohol and Glytrin may lower your blood pressure and slow down your reactions.
If you are, or think you might be pregnant, ask your doctor for advice before taking this medicine. Glytrin should not be used if you are breastfeeding.
Your reactions may slow down. Therefore, you should avoid driving and using machinery whilst taking Glytrin.
This medicine contains 7.5 mg of alcohol (ethanol) in each spray. The amount in one spray of this medicine is equivalent to less than 1 ml beer or 1 ml wine.
The small amount of alcohol in this medicine will not have any noticeable effects.
Continuous use of Glytrin and other nitrates may reduce effectiveness at relieving your symptoms, so high continuous doses should be avoided.
1. Glytrin is not recommended for children.
2. Always use this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
3. Learn how to use Glytrin before the onset of an angina attack, as you may need to use it in a hurry, or in the dark. Familiarise yourself with the spray button, which has a finger rest to help you direct the spray.
4. Keep a spare handy at all times, as it can be difficult to tell how many doses are left in the canister.
5. Do not use Glytrin if you are near a naked flame, e.g. a cigarette.
6. Before using Glytrin for the first time, check that the spray is working by pressing the pump button a few times until it produces a fine mist of liquid. Practice aiming the spray onto a tissue or similar item so that you will be able to aim it correctly under the tongue when you need to use it. If you do not need to use Glytrin very often, remember to check the spray regularly to see that it still works properly.
7. To use Glytrin
8. At the onset of an attack, the recommended dose is one or two sprays under your tongue. If symptoms do not resolve, you can repeat this at 5-minute intervals for a maximum of three sprays in total. If, after that, your symptoms have still not resolved, please seek immediate medical attention. For the prevention of an attack, the recommended dose is one or two sprays 2 to 3 minutes prior to activity likely to cause angina.
9. After using Glytrin, rest for a while. When you stand up, rise slowly, as you may feel faint.
Special treatment is not normally required. Overdose symptoms are usually the same as the stated side effects. Some people may experience a reaction similar to shock, with nausea, weakness and sweating. If you feel faint sit down and raise your legs. Contact your doctor if your symptoms do not improve. Rarely a bluish colour to lips/fingers may occur (cyanosis or methaemoglobinaemia). If this happens contact your doctor immediately.
Like all medicines, this medicine can cause side effects, although not everyone gets them.
Continuous use may result in a tolerance to Glytrin, reducing its effectiveness. If symptoms are not relieved, medical advice should be sought immediately.
Other known side effects are:
Very common (may affect more than 1 in 10 people): Headache
Common (may affect up 1 in 10 people): Vertigo (spinning sensation), dizziness, nausea, facial flushing, weakness
Uncommon (may affect up to 1 in 100 people): Burning sensation, stinging sensation
Rare (may affect up to 1 in 1,000 people): Severe fall in blood pressure, heart rhythm change
Very rare (may affect up to 1 in 10,000 people): Flaking or peeling skin
If you get any side effects, talk to your doctor. This includes any possible side effects not listed in this leaflet.
You can also report side effects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects, you can help provide more information on the safety of this medicine.
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This leaflet was last revised in