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Li-Liquid 509 mg/5ml Oral Syrup

Active Ingredient:
lithium citrate
Rosemont Pharmaceuticals Limited See contact details
ATC code: 
About Medicine
The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine.
Last updated on emc: 21 Oct 2022

Below is a text only representation of the Patient Information Leaflet (ePIL).

The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on {phone} 0800 198 5000. The product code(s) for this leaflet is: PL 00427/0074.

Li-Liquid 509mg/5ml Oral Syrup

Patient Information Leaflet

Li-Liquid™ 509mg/5ml Oral Syrup

Lithium Citrate (equivalent to 200mg/5ml Lithium Carbonate)

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
  • Keep this leaflet. You may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.
    See section 4.

What is in this leaflet

1. What Li-Liquid is and what it is used for
2. What you need to know before you take Li-Liquid
3. How to take Li-Liquid
4. Possible side effects
5. How to store Li-Liquid
6. Contents of the pack and other information

1. What Li-Liquid is and what it is used for

The name of your medicine is Li-Liquid 509mg/5ml Oral Syrup (referred to as Li-Liquid in this leaflet). It contains lithium citrate. This belongs to a group of medicines called ‘anti-manics’.

Lithium acts on the brain to calm your moods and emotions.

Lithium can be used to:

  • treat mania (over-excitability and exaggerated emotions) and hypomania (a milder form of mania)
  • treat bipolar depression. This is a condition where you have large mood swings from low mood and feelings of sadness (depression), to feeling excited and overactive. Lithium will be given when other antidepressant drugs have not worked
  • prevent mood problems that happen a lot
  • control aggressive feelings or if you have been intentionally harming yourself.

2. What you need to know before you take Li-Liquid
Do not take Li-Liquid and tell your doctor if:
  • you are allergic (hypersensitive) to lithium or any other ingredients in this liquid (listed in section 6). The signs of allergic reaction can include a rash, swelling of your lips, face, throat or tongue, itching or shortness of breath
  • you have kidney problems or heart disease
  • you have thyroid problems that are not being treated. The signs of these include tiredness, feeling weak, muscle weakness, cramps, feeling cold, a slow heart rate, dry and flaky skin, hair loss, a deep husky voice or weight gain
  • you are on a low sodium diet or have low body sodium levels, including being dehydrated
  • you have Addison’s disease. This is where your adrenal glands are not working properly. The signs of this are weakness, tiredness, weight loss and low blood pressure
  • you are pregnant, think you are pregnant or breast-feeding
  • you have a rare condition called Brugada syndrome, or if anyone in your family has had Brugada syndrome. This is an abnormal condition of the heart that can make it stop beating.

Do not take this medicine if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Li-Liquid.

Warnings and precautions

Talk to your doctor or pharmacist before taking this medicine if:

  • you currently have a cold or a flu
  • you have gastroenteritis. This is when you have a problem with your stomach or gut. Signs include diarrhoea, stomach pain, being sick, headache, fever and chills
  • you are elderly
  • you have any urinary problems such as infections
  • you are not eating or drinking properly
  • you have kidney problems
  • you are taking medicines to treat epilepsy
  • you have heart problems.

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Li-Liquid.

Kidney tumours: Patients with severe kidney impairment who received lithium for more than 10 years may have a risk of developing a benign or malignant kidney tumour (microcysts, oncocytoma or collecting duct renal carcinoma).

Having operations and tests
  • if you are going into hospital for an operation under general anaesthetic, tell the nurse or doctor that you are taking lithium
  • if you are planning, or have already had weight loss surgery, a lower dose of lithium may be required. Your doctor will monitor the level of lithium in your blood and adjust your dose accordingly
  • it is important to have blood tests before and whilst taking Li-Liquid. These show that you are taking the right dose. They also check whether your heart, thyroid and kidneys are working properly (see Section 3).

Other medicines and Li-Liquid:

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you buy without a prescription, including herbal medicines. This is because Li-Liquid can affect the way some other medicines work.

Also, some medicines can affect the way Li-Liquid works as this can affect the levels of lithium in your blood.

In particular, check with your doctor if you are taking any of the following:

  • Any other medicines containing lithium
  • Medicines used for infections (antibiotics) - such as metronidazole, erythromycin, doxycycline or oxytetracycline
  • Steroids - used for inflammation and allergies (such as prednisolone, betamethasone or hydrocortisone)
  • Theophylline - used for wheezing or difficulty in breathing
  • Caffeine found in some medicines for pain relief that you buy without a prescription
  • Water tablets (diuretics) - such as furosemide, chlortalidone, indapamide, spironolactone or xipamide
  • Urea - used in some creams that soften and moisturise the skin
  • Non-steroidal anti-inflammatory drugs (NSAIDs) - used to treat pain relief and swelling (such as aspirin, ibuprofen, indomethacin or diclofenac)
  • Medicines used for heart problems or high blood pressure – such as enalapril, lisinopril or ramipril (ACE inhibitors)
  • Medicines used to control your heart beat – such as quinidine, disopyramide, procainamide, amiodarone and sotalol
  • Losartan candesartan, irbesartan (called ‘angiotensin II receptor antagonists’)
  • Some medicines for indigestion and heartburn (antacids) - such as sodium bicarbonate and cisapride
  • Calcitonin – used for hypercalcaemia and Paget’s disease/acute bone loss
  • Empagliflozin (used to treat diabetes or heart failure)
  • Dapagliflozin (used to treat diabetes or heart failure or chronic kidney disease).

The following medicines can increase the chance of side effects when taken with Li-Liquid. Tell your doctor if you are taking any of the following before taking Li-Liquid:

  • Some medicines used for depression (SSRIs), tricyclics and triptans derivatives - such as fluvoxamine, paroxetine or fluoxetine
  • Medicines used to calm emotional and mental illnesses - such as haloperidol, flupentixol, diazepam, thioridazine, amisulpride, fluphenazine, chlorpromazine or clozapine. Coadministration with Li-Liquid may increase the risk of a serious but rare side effect called ‘neuroleptic malignant syndrome’, which may be fatal
  • Methyldopa used for high blood pressure
  • Some medicines used for fits (epilepsy) - such as carbamazepine or phenytoin
  • Medicines used for chest pain (angina) or high blood pressure - such as diltiazem or verapamil.

Li-Liquid with food and drink

It is important that you drink plenty of fluids whilst taking this medicine particularly in very hot weather or if your workplace is very hot.

Pregnancy, Breast-feeding and Fertility:

Information for women who could become pregnant

  • if you are planning to become pregnant, talk to your doctor about stopping the medicine
  • you should make sure that you use adequate contraception whilst taking lithium

Information for women who are pregnant

  • if you find out you are pregnant while taking Li-Liquid, tell your doctor straight away
  • do not take Li-Liquid if you are pregnant, especially in the first 3 months of your pregnancy

If your doctor decides that you should have Li-Liquid while you are pregnant, he or she will:

  • keep a close eye on the level of lithium in your blood. This is because your kidneys work differently while you are pregnant
  • arrange for appropriate tests before your baby is born.

If it is decided you should have Li-Liquid during late pregnancy or during labour, your baby may appear ‘floppy’. This returns to normal without any treatment.


  • do not take this medicine if you are breastfeeding. This is because small amounts may pass into the mother’s milk

Driving and using machines:

This medicine may slow down your reactions or make you feel drowsy. If this happens to you, you should not drive or use any tools or machines.

Li-Liquid contains methyl hydroxybenzoate, propyl hydroxybenzoate, propylene glycol, glucose, sorbitol and ethanol:
  • methyl (E218) and propyl hydroxybenzoates (E216). May cause allergic reactions (possibly delayed).
  • propylene glycol (E1520). This medicine contains 155.6mg propylene glycol in each 5ml.
  • glucose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product. It contains 1.7g of glucose in each 5ml. When taken according to dosage recommendations, the maximum dose supplies up to 10.2g of glucose. This should be taken into account in patients with diabetes mellitus and may be harmful to teeth.
  • sorbitol (E420). This medicine contains 454.7mg sorbitol in each 5ml. Sorbitol is a source of fructose. If your doctor has told you that you have an intolerance to some sugars or if you have been diagnosed with hereditary fructose intolerance (HFI), a rare genetic disorder in which a person cannot break down fructose, talk to your doctor before you take or receive this medicine.
  • this medicine contains less than 1 mmol sodium (23 mg) per 5ml, that is to say essentially ‘sodium-free’.
  • ethanol (alcohol). This medicine contains 4.4mg of alcohol (ethanol) in each 5ml. The amount in 5ml of this medicine is equivalent to less than 1 ml beer or 1 ml wine. The small amount of alcohol in this medicine will not have any noticeable effects.

3. How to take Li-Liquid

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Taking this medicine
  • this medicine contains 509mg of lithium citrate in each 5ml. This is the same as 200mg lithium carbonate
  • take this medicine by mouth
  • if you feel that the effect of your medicine is too strong or too weak, do not change the dose yourself, but talk to your doctor or pharmacist
  • your doctor will check your blood levels while you are taking this medicine. These tests will be done just before you are due to take Li-Liquid and not less than 12 hours after your last dose. It is important that you do not miss these tests. The tests will be:
    • 4 to maximum of 7 days after you have started your treatment
    • then every week until your lithium levels are at a constant level in your blood
    • once the levels are stable, you will have this test every 3 months.

Thoughts of harming or killing yourself

If you have a mood disorder, you can sometimes have thoughts of harming or killing yourself. These may be increased when first starting Li-Liquid or changing your dose of Li-Liquid. Like other medicines of this kind, Li-Liquid may not relieve your symptoms straight away. If you have thoughts of harming or killing yourself or worsening of your symptoms at any time, contact your doctor or go to a hospital straight away.

You may find it helpful to tell a relative, close friend or carer that you have a mood disorder, and ask them to read this leaflet. You might ask them to tell you if they think your mood disorder is getting worse, or if they are worried about changes in your behaviour.


The usual dose for adults is:

  • when first taking lithium, two to six 5ml spoonsful. This will be split into two doses, one in the morning and one in the evening.
  • your doctor will then change your dose according to your blood levels.


Lithium is not recommended for children and adolescents.

Older people

If you are an older person you may be more sensitive to the medicine. This means you have more of a chance of getting some of the side effects listed in section 4. Your doctor will start you on a lower dose.

If you take more Li-Liquid than you should

Talk to a doctor or go to a hospital straight away. Take the medicine pack with you so the doctor knows what you have taken.

If you forget to take Li-Liquid

Do not take a double dose (two doses at the same time) to make up for forgotten doses. Skip the missed dose then go on as before.

If you stop taking Li-Liquid

Keep taking Li-Liquid until your doctor tells you to stop. Do not stop taking your medicine suddenly just because you feel better. If you stop, your illness may return. When your doctor says that you can stop taking Li-Liquid, your dose will be lowered gradually. Your doctor will help you to do this.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, lithium can cause side effects, although not everybody gets them.

Stop taking the medicine and contact your doctor or hospital casualty department straight away if you get:
  • an allergic reaction to Li-Liquid such as skin rash, flaking skin, boils or sore lips and mouth, sudden wheezing, fluttering or tightness of the chest or collapse

Stop taking this medicine and contact your doctor or hospital casualty department straight away if you notice a combination of any of the following serious side effects. The following side effects may be signs of lithium toxicity (too much lithium in your blood):
  • loss of appetite, diarrhoea and vomiting (being sick)
  • muscle weakness, lack of co-ordination, muscle twitching or sudden jerks and shaking
  • feeling drowsy or very tired, balance problems and feeling dizzy with a spinning sensation (vertigo)
  • difficulty in walking or unusual involuntary movements such as unusual eye movements
  • ringing in the ears (tinnitus) or blurred vision
  • difficulty in speaking or slurred speech
  • altered mental state due to brain disease, damage or malfunction (encephalopathy).

Other serious side effects which need urgent medical attention:
  • swelling around the feet and ankles, face and stomach and weight gain due to water retention
  • cloudy or foamy urine (water)
  • feeling confused, dazed, delirious or loss of consciousness
  • memory problems
  • fits (seizures)
  • irregular or slow heartbeat, shortness of breath, chest pain and fainting
  • low blood pressure (causes dizziness and feeling faint)
  • abnormal muscle breakdown (rhabdomyolysis) which can lead to kidney problems and passing of abnormally coloured urine
  • if you have a high fever, agitation, confusion, trembling and abrupt contractions of muscles as these may be signs of a rare condition called serotonin syndrome
  • if you experience a high temperature with rigid muscles, confusion, agitation and sweating or jerky muscle movements which you can’t control, these may be symptoms of a serious condition known as neuroleptic malignant syndrome
  • the above symptoms may increase the risk of a fall and an injury as a result of the fall.

Frequency unknown:

  • kidney tumours (lumps) or cancers (in long-term therapy)
  • eruption or thickening of the skin or mucous membranes (lichenoid drug reaction).

Tell your doctor as soon as possible if you get any of the following serious side effects:
  • increased thirst and passing water (urine) more often than normal. You may also feel tired and hungry. This could be due to high blood sugar levels or a condition called “diabetes insipidus”

It is important to tell your doctor if you are passing more water than usual as the amount of Li-Liquid you are taking may need to be changed.

  • you have a swelling or a lump on your neck (which may be caused by an enlarged thyroid gland)
  • you have a fast heartbeat, sweating, stress (anxiety), increased appetite, loss of weight, weakness and are unable to tolerate heat. This could be due to higher levels of thyroid hormone in the blood (hyperthyroidism)
  • you feel tired, have cold skin and hair becomes dry, thinning of hair or fingernails, hoarse voice, joint or muscle pain and gain weight. This could be due to lower levels of thyroid hormone in the blood (hypothyroidism)
  • you have increased thirst, pass more water than usual, feel tired or depressed, muscle aches or pains, bone or joint pain and stomach upsets. This could be due to a hormone problem called “hyperparathyroidism”
  • you have indigestion or heartburn and are feeling sick, being sick or have abdominal pain. You may also have tarry stools (faeces) or blood in your stools or you may notice blood or dark bits (like coffee grounds) when you are being sick. This could be due to a stomach problem called “gastritis”
  • headaches, a “rushing” sound in your ears and feeling or being sick. This could be because of increased pressure in the brain
  • numbness, weakness and pain in the arms and legs (peripheral neuropathy).

Tell your doctor or pharmacist if any of the following side effects gets serious or lasts longer than a few days:
  • hair loss or inflamed hair follicles
  • acne, skin spots or rashes, skin ulcers and/or itching
  • slight shaking of the hands
  • you have skin irritation and swelling. Skin may appear red, itchy with silvery scales (psoriasis). If you already have this condition, you could notice that it is getting worse
  • feeling sick, vomiting, a watery or dry mouth and/or changes in the way things taste
  • stomach pain or stomach upset
  • sexual problems including being unable to get an erection, having delayed ejaculation or being unable to have an orgasm
  • blurred vision or blind spots in your eyesight
  • uncontrolled movements of the eye
  • weight gain
  • feeling giddy.


A change in blood tests may occur, particularly high white blood cell counts, high blood sugar levels, and high magnesium or calcium levels. Your doctor will notice this when you have your blood tests.

A test on your heart may show changes in the way your heart is working.

Lithium taken for a long time can cause kidney damage. This can usually be avoided if your kidney function is tested regularly by your doctor. Drinking plenty of fluids while taking this medicine will also help avoid kidney damage.

If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at or search for MHRA Yellow Card in the Google Play or Apple App Store.

By reporting side effects you can help provide more information on the safety of this medicine.

5. How to store Li-Liquid
  • Keep out of the sight and reach of children
  • Store above 4°C and keep out of direct sunlight
  • Do not use after the expiry date which is stated on the label and carton. (exp: month, year)
  • The expiry date refers to the last day of that month
  • Do not use Li-Liquid if you notice that the appearance or smell of your medicine has changed. Talk to your pharmacist
  • Medicines should not be disposed of via wastewater or household waste. Take back to the pharmacy 6 months after you first open it. These measures will help to protect the environment.

6. Contents of the pack and other information
What Li-Liquid contains
  • The active ingredient is lithium citrate. Each 5ml contains 509mg of lithium citrate. This is the same as 200mg lithium carbonate
  • The other ingredients are citric acid (E330), saccharin sodium, sorbitol solution (E420), syrup liquid glucose, propylene glycol (E1520), methyl hydroxybenzoate (E218), propyl hydroxybenzoate (E216), quinoline yellow (E104), cherry flavour (containing ethanol and propylene glycol) and purified water.

What Li-Liquid looks like and contents of the pack

A bright yellow syrup with an odour of cherry.

It comes in a brown glass bottle holding 150ml of syrup.

Marketing Authorisation Holder and Manufacturer
Rosemont Pharmaceuticals Ltd
Yorkdale Industrial Park
Braithwaite Street
LS11 9XE

This leaflet was last revised in 07/2022

Rosemont Pharmaceuticals Limited
Company image
Rosemont House, Yorkdale Industrial Park, Braithwaite Street, Leeds, Yorkshire, LS11 9XE
+44 (0)113 244 1400
+44 (0)113 245 3567
Customer Care direct line
+44 (0)800 919 312
Out of Hours Telephone
+44 (0)795 762 3515
Out of Hours contact
[email protected]