Neostigmine Methylsulfate Injection BP 2.5mg in 1ml

• are allergic to neostigmine or any of the other ingredients in this medicine (listed in section 6).
• have an intestinal obstruction or cannot urinate.
• have peritonitis (an infection or inflammation of the outer layer of your stomach or intestines).
• have a condition where your bowel may no longer be functioning.
• you are receiving certain muscle relaxants (e.g. Suxamethonium).

Talk to your doctor or nurse before being given the injection if you have:

• asthma
• epilepsy
• a slow pulse
• any heart disease
• vagotonia (you may suffer from sweating, constipation and involuntary movements)
• an overactive thyroid gland
• a stomach ulcer
• Parkinson’s Disease
• an anastomosis (an opening created by surgery, trauma, or disease) in your intestine

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This is especially important with the following medicines as they may interact with your Neostigmine Methylsulfate Injection :

• you are receiving antibiotics known as aminoglycosides.

This medicine contains 3.54 mg (0.15 mmol) sodium (main component of cooking/table salt) per 1 ml ampoule, that is to say essentially ‘sodium-free’.

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

You should not drive or use machinery if you are affected by the administration of Neostigmine Methylsulfate Injection.

• Swelling of the face, lips or throat which makes it difficult to swallow or breathe, rash, itching, hives and dizziness.

This could be a sign of an angioedema or a severe allergic reaction (frequency not known, cannot be estimated from the available data).

You may (frequency not known, cannot be estimated from the available data):

• feel or actually be sick
• produce more saliva than usual
• produce more tears than usual
• suffer from bronchial spasm and increased bronchial secretion
• suffer from diarrhoea and stomach cramps
• have constricted (pin-point) pupils in your eye
• suffer from urinary incontinence (you pass urine when you do not mean to)
• suffer from excessive sweating
• have a slow pulse
• suffer from hypotension (blood pressure that is much lower than usual)
• suffer from muscle spasms

If you experience any of the side effects listed this may mean that you have been given an overdose and you should tell a doctor immediately.

If you get any side effects, talk to your doctor, pharmacist or nurse: This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

The active ingredient is Neostigmine Methylsulfate. Each 1 ml of solution contains 2.5 mg neostigmine methylsulfate.

The other ingredients are Sodium Chloride, Sterile Water for Injections.

Neostigmine Methylsulfate Injection is a clear colourless solution in clear glass ampoules containing 2.5 mg neostigmine methylsulfate in 1 ml. 10 ampoules are supplied in each carton.

The marketing authorisation number of this medicine is: PL 01502/0023

For any information about this medicine, please contact the Marketing Authorisation Holder