Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.

• Keep this leaflet. You may need to read it again.
• Ask your pharmacist if you need more information or advice.
• If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.
• You must talk to a doctor if you do not feel better or if you feel worse after 3 days.
• The full name of this medicine is Boots Period Pain Reliever 250mg Gastro-Resistant Tablets, but within this leaflet it will be referred to as Period Pain Reliever.

1. What Period Pain Reliever is and what it is used for
2. What you need to know before you take Period Pain Reliever
3. How to take Period Pain Reliever
4. Possible side effects
5. How to store Period Pain Reliever
6. Contents of the pack and other information

• are allergic to naproxen, medicines containing naproxen sodium or to any of the other ingredients of this medicine (listed in section 6)
• are allergic to aspirin, ibuprofen or other non-steroidal anti-inflammatory medicines (NSAIDs), or you have developed signs of asthma (wheezing), runny nose, swelling of the skin or rash when taking these medicines
• have or have had stomach or duodenal (gut) ulcers, bleeding in the stomach or intestines (gastrointestinal bleeding) or have had two or more episodes of stomach ulcer, perforation or bleeding
• have severe heart failure, liver or kidney failure
• are in the last three months of pregnancy.

If you are not sure about any of the above conditions, please ask your doctor.

Talk to your doctor or pharmacist before taking Period Pain Reliever if you:

• are on a low potassium diet, as this product contains potassium sorbate. High blood levels of potassium can cause stomach upset and diarrhoea
• have a history of gastrointestinal disease e.g. ulcerative colitis, Crohn’s disease
• are elderly or frail, you have a higher risk of getting side effects, especially of the stomach. If you experience any unusual symptoms from the stomach, you must tell your doctor about it
• have or have had high blood pressure, a stroke or any heart, liver or kidney problems
  • if you have kidney or liver problems you should only take Period Pain Reliever under the supervision of your doctor, for monitoring of your kidney or liver function
  • medicines such as naproxen may be associated with a small increased risk of heart attack (myocardial infarction) or stroke. Any risk is more likely with high doses and prolonged treatment. Do not exceed the recommended dose or duration of treatment
• have asthma, diabetes, high cholesterol
• are a smoker
• drink alcohol
• have systemic lupus erythematosus or other connective tissue disorders
• have Stevens-Johnson syndrome or toxic epidermal necrolysis (severe skin problems)
• have any blood clotting disorders
• first experienced period pain more than a year after starting your periods
• are a woman trying to become pregnant or undergoing investigation of infertility. Naproxen belongs to a group of medicines which may impair fertility in women. This effect is reversible on stopping the medicine. It is unlikely that naproxen, used occasionally, will affect your chances of becoming pregnant. However, tell your doctor before taking this medicine if you have problems becoming pregnant
• Period Pain Reliever may hide the symptoms of an infection.

When taking Period Pain Reliever, inflammation in your kidney may occur. Signs and symptoms may include decreased volume of urine or blood in your urine and/or hypersensitivity reactions such as fever, rash, and joint stiffness. You should report such signs to the treating physician.

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines obtained with or without a prescription. Especially:

• other non-steroidal anti-inflammatory drugs (NSAIDs) e.g. COX II inhibitors (used for pain and inflammation)
• aspirin/acetylsalicylic acid to prevent blood clots
• antacids (to treat heartburn)
• medicines to treat high blood pressure including angiotensin II receptor antagonists or ACE inhibitors, such as captopril, ramipril or propranolol
• diuretics (‘water tablets’), such as furosemide
• cardiac glycosides (for heart failure), such as digoxin
• lithium (used for some mental health problems)
• methotrexate (to treat some cancers)
• ciclosporin, tacrolimus (to suppress the immune system)
• mifepristone (used for termination of pregnancy). Period Pain Reliever should not be taken within 8-12 days of taking mifepristone
• corticosteroids (used in many different diseases), such as prednisolone
• medicines which thin the blood or prevent blood clotting such as warfarin
• SSRI antidepressants (for depression), such as fluoxetine
• medicines used to treat Type 2 diabetes such as sulphonylurea
• quinolone antibiotics (to treat bacterial infections), such as ciprofloxacin
• probenecid (used for gout)
• hydantoins (in epilepsy) such as phenytoin
• zidovudine (anti-viral)
• colestyramine (for high cholesterol) (take naproxen 1 hour before or 4 to 6 hours after colestyramine to avoid interference with absorption).

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Do not take Period Pain Reliever if you are in the last 3 months of pregnancy as it could harm your unborn child or cause problems at delivery. It can cause kidney and heart problems in your unborn baby. It may affect your and your baby’s tendency to bleed and cause labour to be later or longer than expected.

You should not take Period Pain Reliever during the first 6 months of pregnancy unless absolutely necessary and advised by your doctor. If you need treatment during this period or while you are trying to get pregnant, the lowest dose for the shortest time possible should be used. If taken for more than a few days from 20 weeks of pregnancy onward, naproxen can cause kidney problems in your unborn baby that may lead to low levels of amniotic fluid that surrounds the baby (oligohydramnios) or narrowing of a blood vessel (ductus arteriosus) in the heart of the baby. If you need treatment for longer than a few days, your doctor may recommend additional monitoring.

Period Pain Reliever does not normally cause any effects, however you may experience drowsiness, dizziness, spinning sensation, difficulty in sleeping, disturbed vision or depression. If you are affected do not drive or operate machinery.

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free’.

If you need any blood or urine tests, tell your doctor you are taking Period Pain Reliever. The tablets may need to be stopped 48 hours before a test, as they may interfere with the results.

First day of treatment

Initially take two tablets (500mg) then if needed, one tablet (250mg) after 6-8 hours.

Second and third day of treatment

If needed, take one tablet (250mg) every 6-8 hours.

Do not take more than the maximum dose of three tablets a day for longer than three days during each month (menstrual cycle).

It is important not to take too many tablets. Contact your doctor, pharmacist or nearest hospital casualty department immediately if you have taken more tablets than you should.

Symptoms of an overdose are headache, heartburn, feeling or being sick, stomach pain or bleeding, diarrhoea, disorientation, excitation, drowsiness, dizziness, ringing in the ears, fainting.

If you forget to take a tablet, take your forgotten dose as soon as you remember, unless it is nearly time for your next dose. Do not take a double dose to make up for a forgotten dose.

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

• The active substance (the ingredient that makes the medicine work) is naproxen. Each tablet contains 250mg of the active substance.
• The tablet is gastro-resistant, which means that it is covered with a coating which stops the tablet dissolving in the stomach, so that the naproxen is released further down in your gut.
• The other ingredients are methacrylic acid-ethylacrylate copolymer (1:1), lactose, magnesium stearate, maize starch, crospovidone, propylene glycol, sodium hydroxide, triethyl citrate, titanium dioxide (E171), potassium sorbate (E202), sodium citrate (E331), xanthan gum (E415), hydroxypropyl cellulose (E463), purified talc (E553), beeswax.

Period Pain Reliever tablets are white, round, biconvex, enteric-coated tablets.

Pack size: 9 tablets