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Adrenaline (Epinephrine) Injection 1:10,000 (pre-filled syringe)
Adrenaline (Epinephrine) Injection 1:10,000
(Referred to as ‘Adrenaline injection’ in this leaflet)
Adrenaline acid tartrate
1. What Adrenaline injection is, and what it is used for
2. What you need to know before Adrenaline injection is given
3. How Adrenaline injection is given
4. Possible side effects
5. How to store Adrenaline injection
6. Contents of the pack and other information
Adrenaline injection belongs to a group of medicines called adrenergic and dopaminergic agents.
If you are allergic (hypersensitive) to any ingredients of this medicine (listed in section 6) where an alternative presentation of Adrenaline or alternative vasopressor is available.
Adrenaline injection is indicated for emergency treatment. Continuous medical supervision is necessary after administration.
The risk of side effects is increased if you:
Tell your doctor if you are taking, have recently taken or might take any other medicines.
Medicines that may interact with Adrenaline injection include:
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before you are given this medicine.
Having Adrenaline injection does not affect your ability to drive or use machines.
Adrenaline injection contains sodium This medicinal product contains 2.70 mg of sodium per ml of solution for injection. This needs to be taken into consideration by patients on strict sodium diet.
The product also contains Sodium Metabisulphite which may cause allergic (hypersensitive) type reactions in some people and can lead to breathing difficulties or collapse. People with a history of asthma or allergies are most likely to experience these problems.
Your doctor, nurse or paramedic will give Adrenaline injection to you either into a vein (intravenous) or into a bone (intraosseous). Your doctor will decide the correct amount for you, and when and how this should be given.
Adrenaline must not be injected into the fingers, toes, ears, nose or genital area.
In case of life threatening allergic reactions (acute anaphylaxis):
Adults will be given a dose of 0.05 mg (0.5 ml of Adrenaline 1:10,000 solution) repeated as necessary until the desired response is achieved.
In case of cardiac arrest:
Adults: 1 mg (10 ml of Adrenaline 1:10,000 solution) is given into a vein or into a bone every 3-5 minutes until the heart starts to work.
Children above 5 kg: 10 micrograms/kg (0.1 ml/kg of Adrenaline 1:10,000 solution) is given into a vein or into a bone every 3-5 minutes until the heart starts to work.
This medicinal product is not suitable for delivering a dose of less than 0,5 ml and should therefore, not be used in neonates and infants for which the body weight is less than 5 kg.
Like all medicines, Adrenaline injection can cause side effects, although not everybody gets them.
In high dosages or for patients sensitive to adrenaline, side effects are:
Repeated local injections may produce necrosis (tissue damage) at the site of injection as a result of vascular constriction (blood vessel constriction).
In all cases, after administration of Adrenaline injection medical supervision is necessary.
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Yellow Card Scheme - Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
Keep out of the sight and reach of children.
Your doctor, nurse or paramedic will check that the expiry date on the label has not passed before giving Adrenaline injection to you. The expiry date refers to the last day of that month.
Adrenaline (Epinephrine) is sensitive to light, therefore Adrenaline injections must always be kept in the original outer carton.
Do not store above 25°C and do not freeze.
You should not be given Adrenaline injection if it has been used or shows signs of visible damage.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
The active ingredient is Adrenaline (Epinephrine) as acid tartrate.
Each 10ml solution for injection contains 1mg of adrenaline(epinephrine) as the acid tartrate.
The other ingredients are Sodium Chloride, Citric Acid Monohydrate, Sodium Citrate Dihydrate, Sodium Metabisulphite and Water for Injections. Dilute Hydrochloric acid may be added to adjust the acidity.
Adrenaline injection is a clear colourless solution supplied in a pre-filled syringe. Each prefilled syringe contains 10ml of the solution.
This leaflet was last revised in 03/2018