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Isosorbide dinitrate 0.1%w/v Concentrate for Solution for Injection or Infusion
Isosorbide Dinitrate 0.1% w/v Concentrate for Solution for Injection or Infusion
1. What Isosorbide Dinitrate 0.1% w/v Concentrate for Solution for Injection or Infusion is and what it is used for
2. What you need to know before you are given Isosorbide Dinitrate 0.1% w/v Concentrate for Solution for Injection or Infusion
3. How to use Isosorbide Dinitrate 0.1% w/v Concentrate for Solution for Injection or Infusion
4. Possible Side Effects
5. How to store Isosorbide Dinitrate 0.1% w/v Concentrate for Solution for Injection or Infusion
6. Contents of the pack and other information
Isosorbide dinitrate, the active ingredient, belongs to a group of medicines called vasodilators used in the treatment of heart disease. It works by widening the arteries and veins so decreasing the resistance to blood flow and lowering blood pressure.
This medicine is a concentrated solution for injection or infusion and is used for the treatment of heart problems. It is specifically used for:
Please tell your doctor if you are taking any other medication.
If any of the above applies to you talk to your doctor or pharmacist.
Talk to your doctor or pharmacist before using Isosorbide Dinitrate 0.1% w/v Concentrate for Solution for Injection or Infusion if:
Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines.
You should not be given Isosorbide Dinitrate with phosphodiesterase inhibitors such as Sildenafil (“Viagra”) used for impotence. Using Isosorbide Dinitrate with these medicines could cause your blood pressure to fall to a dangerously low level.
It is especially important to tell your doctor or pharmacist if you are taking any of the following medicines:
Do not drink alcohol. It could increase the effect of Isosorbide Dinitrate and lower your blood pressure too much. If this happens, you may feel dizzy or faint.
If you are pregnant, trying to become pregnant or breast-feeding, ask your doctor or pharmacist for advice before being given Isosorbide Dinitrate 0.1% w/v Concentrate for Solution for Injection or Infusion. Your doctor will decide whether you should be given this medicine.
Isosorbide Dinitrate may give you a headache, or make you feel dizzy or tired. If this happens to you, do not drive or operate machinery.
This medicine contains less than 1mmol sodium (23mg) per 1mg per 1mL, that is to say it is essentially ‘sodium-free’.
Always use this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
The doctor will decide what dose of this medicine you should be given. Check the label carefully. If you are not sure, ask your doctor, nurse or pharmacist.
This medicine must be diluted before use with sodium chloride or glucose. It should never be used undiluted.
This medicine is either given by infusion into a vein or by direct injection into the coronary artery. Doses will be adjusted by your doctor, but the usual dose is between 2mg and 12mg per hour, although sometimes as much as 20mg per hour is necessary. The normal dose for direct injection into the coronary artery is 1mg. Further doses may be given if your doctor thinks it necessary.
The injection is for single use only, so once the ampoule or vial is opened the medicine should be used immediately and any unused medicine discarded.
As this medicine is used in hospital, your heartbeat (pulse) and blood pressure will be carefully monitored whilst you are being given Isosorbide Dinitrate. This is to make sure that your medicine is working properly and that the dose you are taking is right for you.
Use in Children
This medicine is not suitable for children. If you have any further questions about the use of this medicine, ask your doctor or pharmacist.
Tell your doctor as soon as possible. If you are a medical practitioner administering this medicine please refer to the Summary of Product Characteristics.
An overdose of Isosorbide Dinitrate may cause your blood pressure to be too low resulting in paleness, sweating, weak pulse, fast heartbeat, light-headedness on standing, headache, weakness, dizziness, feeling sick, being sick and diarrhoea. If you have any concerns about this tell your doctor or nurse.
The dose should be given as soon as it is remembered. The next dose should be given at the usual time. Do not take a double dose to make up for a forgotten dose.
Like all medicines, this medicine can cause side effects, although not everyone gets them.
Your pulse and blood pressure may be monitored during administration (because of these effects).
Tell your doctor, nurse or pharmacist immediately if you think you have any of these, or other problems.
If you get any side effects, talk to your doctor, nurse or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
This medicine is a clear and colourless solution. This medicine comes in 10mL single use ampoules and 50mL single use vials. The medicine is packed into cartons containing 10 ampoules, 1 vial or 10 vials. Both pack sizes of vials may not be available at the same time.
This leaflet was last revised in: October 2023