The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL 29831/0119.
Hypurin Porcine Neutral 100I.U/ml Injection, Hypurin Porcine Isophane 100 I.U/ml Injection, Hypurin Porcine 30-70 Mix 100 I.U Injection (PL 29831/0124,0122,0119)
HYPURIN® PORCINE RANGE OF INSULIN INJECTION
1. What Hypurin is and what it is used for
2. What you need to know before you use Hypurin
3. How to use Hypurin
4. Possible side effects
5. How to store Hypurin
6. Contents of the pack and other information
The name of your medicine is Hypurin Porcine Insulin. Hypurin Porcine is the brand name for a range of highly purified porcine (pig) insulin injections.
Hypurin Porcine Neutral is a sterile, clear solution of porcine insulin (100 international units/ml). It is short acting.
Hypurin Porcine Isophane is a sterile, white suspension of porcine insulin (100 international units/ml) with protamine sulfate and zinc chloride in water. It is longer acting than Hypurin Porcine Neutral.
Hypurin Porcine 30/70 Mix is a sterile, white suspension of porcine neutral and isophane insulins (100 international units/ml). It is intermediate acting.
Hypurin contains insulin which is a natural hormone, made by a gland called the pancreas. Insulin plays a key role in the way the body uses carbohydrate, fat and protein. Hypurin Porcine is used for the treatment of insulin-dependent diabetes mellitus. In this type of diabetes, your pancreas does not make enough insulin to control the level of sugar in your blood. It can be treated by controlling your diet and taking insulin. Hypurin Porcine has been prescribed for you as a substitute for your own insulin.
If any of the above applies to you, should not inject Hypurin.
Talk to your doctor before taking this medicine if you are taking pioglitazone, as your risk of heart failure may be increased.
Hypurin Porcine Insulin in cartridges is only suitable for injection just under the skin using a reusable pen. Speak to your doctor if you need to inject your insulin by another method.
The injection site should be rotated to prevent skin changes such as lumps under the skin. The insulin may not work very well if you inject into a lumpy area (see How to use Hypurin). Contact your doctor if you are currently injecting into a lumpy area before you start injecting in a different area. Your doctor may tell you to check your blood sugar more closely, and to adjust your insulin or your other antidiabetic medications dose.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes medicines you may have bought yourself without a prescription.
Taking another medicine while you are using insulin can affect how it or the other medicine works.
Medicines that can affect the way insulin works are;
Alcohol and smoking can also affect the way insulin works. If you have any doubts about your medicine then discuss things more fully with your doctor, pharmacist or diabetes nurse.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine.
Particularly careful control of your diabetes and prevention of hypoglycaemia is important for your health and the health of your baby.
Insulin requirements should be assessed frequently by an experienced diabetes physician during pregnancy, after delivery and whilst breast-feeding.
Your ability to concentrate or react may be reduced if you have hypoglycaemia. This might put yourself and others at risk when you are driving a car or operating machinery.
You should contact your doctor about the advisability of driving if you have:
Zinc, protamine and the preservatives m-cresol and phenol may cause allergic reactions.
Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
There is no ‘standard’ dose of insulin. Each person with diabetes has their own dose calculated according to their needs. Your doctor will decide which dose is best for you and which insulin to use.
Always follow your doctor’s instructions exactly and also follow any special instructions or warnings that appear on the label that the pharmacist has put on the package.
Patients with disease of the liver, kidneys, adrenal, pituitary or thyroid glands, or coeliac disease (symptoms may include severe diarrhoea and unintentional weight loss) may need lower doses.
This dose may alter during illness (including infection and surgery), injury, emotional stress, during puberty, around the time of a menstrual period, and during pregnancy and after delivery. Lactating women may also require dosage adjustments. It may also change with your diet and lifestyle, particularly if you are exercising more.
Patients transferred to Hypurin Porcine Insulins from other types of insulin may require dosage adjustments. Newly diagnosed diabetic patients may require dosage adjustments during the first weeks, months or years of treatment.
If you do not understand or are in any doubt ask your doctor, pharmacist or diabetes nurse.
Recommended injection sites include the upper arms, thighs, buttocks and lower abdomen. It may be preferable to use those areas that are less visible. Each time you inject your insulin you should use a different spot in the same general area. Change to a different injection area each week.
Hypurin Porcine Insulin in cartridges is only suitable for injecting just under the skin using a reusable pen. Speak to your doctor if you need to inject your insulin by another method.
Hypurin Porcine Isophane or Hypurin Porcine 30/70 Mix should not be injected into a vein.
Hypurin Porcine Neutral may be injected into a vein, but only by a doctor in an emergency.
Your doctor or diabetes nurse will advise you on how to inject your insulin.
If you think you have received too much Hypurin, contact your doctor or diabetes nurse immediately. Symptoms of an overdose include weakness, sweating, trembling, nervousness, excitement and irritability which, if untreated, could lead to collapse and coma.
If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Rarely the following side effects may occur:
Hypoglycaemia means low blood sugar. The symptoms of a “hypo” are:
Hypoglycaemia may occur for the following reasons (or occasionally for no apparent reason):
Untreated “hypos” can have serious consequences. It is important to recognise the symptoms and treat hypoglycaemia early.
If you inject insulin too often at the same place, the fatty tissue may either shrink (lipoatrophy) or thicken (lipohypertrophy). Lumps under the skin may also be caused by build-up of a protein called amyloid (cutaneous amyloidosis). The insulin may not work very well if you inject into a lumpy area. Change the injection site with each injection to help prevent these skin changes.
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects you can help provide more information on the safety of this medicine.
Keep all cartridges, needles and pens out of the sight and reach of children.
Hypurin Porcine Neutral is a sterile, clear solution of porcine insulin (100 international units/ml).
It also contains m-cresol, phenol, glycerol and sodium phosphate.
Hypurin Porcine Isophane is a sterile, white suspension of porcine insulin (100 international units/ml) with protamine sulfate and zinc chloride in water. It also contains m-cresol, phenol, glycerol and sodium phosphate.
Hypurin Porcine 30/70 Mix is a sterile, white suspension of porcine neutral and isophane insulins (100 international units/ml). It also contains m-cresol, phenol, glycerol and sodium phosphate.
Hypurin Porcine is available in packs of five glass cartridges, which contain 3ml of solution or suspension for use in pen injectors and glass vials, which contain 10ml of solution or suspension.
To listen to or request a copy of this information in Braille, large print or audio please call, free of charge:
0800 198 5000 (UK only)
Please be ready to give the following information:
Product name Reference number
Hypurin® Porcine Neutral 100 IU/ml Insulin Injection 29831/0124
Hypurin® Porcine Isophane 100 IU/ml Insulin Injection 29831/0122
Hypurin® Porcine 30/70 Mix 100 IU/ml Insulin Injection 29831/0119
Marketing Authorisation Holder
This leaflet was last revised in 06/2020