The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL29831/0061.
Diamorphine Hydrochloride 5mg, 10mg, 30mg, 100mg and 500mg for Injection
Diamorphine Hydrochloride 5mg, 10mg, 30mg, 100mg and 500mg for Injection
This medicine contains diamorphine hydrochloride which is an opioid, which can cause addiction. You can get withdrawal symptoms if you stop taking it suddenly.
1. What Diamorphine Injection is and what it is used for
2. What you need to know before you are given Diamorphine Injection
3. How Diamorphine Injection should be given
4. Possible side effects
5. How to store Diamorphine Injection
6. Contents of the pack and other information
This medicine had been prescribed for you to relieve moderate to severe pain. Diamorphine is used for the relief of severe pain associated with surgical procedures, heart attack and pain in terminally ill patients.
It is also used to treat breathlessness caused by fluid in the lungs.
It contains diamorphine hydrochloride which belongs to a class of medicines called opioids, which are ‘pain relievers’.
This medicine has been prescribed to you and should not be given to anyone else.
Opioids can cause addiction and you may get withdrawal symptoms if you stop taking it suddenly. Your prescriber should have explained how long you will be taking it for and when it is appropriate to stop, how to do this safely.
Talk to your doctor before Diamorphine Injection is given if you:
Taking this medicine regularly, particularly for a long time, can lead to addiction. Your prescriber should have explained how long you will be taking it for and when it is appropriate to stop, how to do this safely.
Rarely, increasing the dose of this medicine can make you more sensitive to pain. If this happens, you need to speak to your prescriber about your treatment.
Addiction can cause withdrawal symptoms when you stop taking this medicine. Withdrawal symptoms can include restlessness, difficulty sleeping, irritability, agitation, anxiety, feeling your heartbeat (palpitations), increased blood pressure, feeling or being sick, diarrhoea, loss of appetite, shaking, shivering or sweating. Your prescriber will discuss with you how to gradually reduce your dose before stopping the medicine. It is important that you do not stop taking the medicine suddenly as you will be more likely to experience withdrawal symptoms.
Opioids should only be used by those they are prescribed for. Do not give your medicine to anyone else. Taking higher doses or more frequent doses of opioid, may increase the risk of addiction. Overuse and misuse can lead to overdose and/or death.
If any of the above apply to you, speak to your doctor or nurse before Diamorphine Injection is given to you.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
In particular, tell your doctor if you are taking any of the following:
You should not drink alcohol whilst being given Diamorphine Injection as it will increase its effects.
Do not take Diamorphine Injection if you are pregnant or think you might be pregnant unless you have discussed this with your prescriber and the benefits of treatment are considered to outweigh the potential harm to the baby.
If you use Diamorphine Injection during pregnancy, your baby may become dependent and experience withdrawal symptoms after the birth which may need to be treated.
Do not take Diamorphine Injection while you are breastfeeding as diamorphine hydrochloride passes into breast milk and will affect your baby.
You may feel drowsy and confused when you are being given Diamorpine Injection so you should not drive or operate machinery.
This medicine can affect your ability to drive.
Do not drive whilst taking this medicine until you know how this medicine affects you.
It may be an offence to drive if your ability to drive safely is affected.
There is further information for patients who are intending to drive in Great Britain - go to http://www.gov.uk/drug-driving-law
Your prescriber should have discussed with you, how long the course of treatment will last. They will arrange a plan for stopping treatment. This will outline how to gradually reduce the dose and stop taking the medicine.
If you think that an injection has been missed, speak to your doctor or nurse.
Do not suddenly stop taking this medicine. If you want to stop taking this medicine, discuss this with your prescriber first. They will tell you how to do this, usually by reducing the dose gradually so that any unpleasant withdrawal effects are kept to a minimum. Withdrawal symptoms such as restlessness, difficulty sleeping, irritability, agitation, anxiety, feeling your heartbeat (palpitations), increased blood pressure, feeling or being sick, diarrhoea, shaking, shivering or sweating may occur if you suddenly stop taking this medicine.
Like all medicines, this medicine can cause side effects, although not everybody gets them. Tell your doctor or nurse immediately if you experience the following serious side effect:
Difficulty in breathing and physical and psychological dependence are possible serious side effects.
It is possible that you could become dependent on diamorphine.
Other side effects include:
Apart from constipation, these side effects tend to disappear with time.
When you stop taking Diamorphine Injection, you may experience drug withdrawal symptoms, which include restlessness, difficulty sleeping, irritability, agitation, anxiety, feeling your heartbeat (palpitations), increased blood pressure, feeling or being sick, diarrhoea, shaking, shivering or sweating.
If you notice any of the following signs whilst taking Diamorphine Injection, it could be a sign that you have become addicted.
If you notice any of these signs, it is important you talk to your prescriber
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting systems listed below:
Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Store the ampoules below 25ºC. Keep the ampoule in its outer carton, in order to protect it from light.
Do not use Diamorphine Injection if the powder in the ampoule or resulting solution shows signs of discolouration.
Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste.
Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.
The active substance is diamorphine hydrochloride. There are no other ingredients present.
The injection is a white to off-white, sterile, freeze dried powder for reconstitution for injection.
Diamorphine Injection is available in five strengths (5mg, 10mg, 30mg, 100mg, or 500mg of diamorphine hydrochloride) in packs of 5, 10 or 50 ampoules.
Not all strengths and pack sizes may be marketed.
Marketing Authorisation Holder in UK:
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Product Name Reference Number
Diamorphine Hydrochloride 5mg for Injection 29831/0062
Diamorphine Hydrochloride 10mg for Injection 29831/0063
Diamorphine Hydrochloride 30mg for Injection 29831/0064
Diamorphine Hydrochloride 100mg for Injection 29831/0061
Diamorphine Hydrochloride 500mg for Injection 29831/0060
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This leaflet was last revised in 11/2021