The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL 29831/0714.
Captopril 25mg-5ml & 5mg-5ml Oral Solution
Captopril 5mg/5ml Oral Solution
Captopril 25mg/5ml Oral Solution
1. What Captopril Oral Solution is and what it is used for
2. What you need to know before you take Captopril Oral Solution
3. How to take Captopril Oral Solution
4. Possible side effects
5. How to store Captopril Oral Solution
6. Contents of the pack and other information
Captopril Oral Solution contains the active substance captopril which belongs to the group of medicines called Angiotensin Converting Enzyme (ACE) Inhibitors. ACE inhibitors work by helping to widen your blood vessels, which then make it easier for your heart to pump blood through them.
Captopril is used to treat the following in adults, the elderly and children:
If any of the above applies to you or your child you should ask your doctor's advice before taking this medicine.
Talk to your doctor or pharmacist or nurse before taking Captopril Oral Solution.
If you are taking any of the following medicines used to treat high blood pressure:
Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (e.g. potassium) in your blood at regular intervals.
See also information under the heading 'Do not take Captopril Oral Solution'
You must tell your doctor if:
If you are receiving immunosuppressant therapy your doctor may carry out a number of tests during your treatment with Captopril Oral Solution to make sure that you are showing no signs of an infection. If you begin to have symptoms of an infection such as a sore throat or fever you should contact your doctor immediately.
If you suffer from kidney disease your doctor may carry out a number of tests both before and during your treatment with Captopril Oral Solution to check the levels of protein in your urine.
If you are to have desensitisation treatment for wasp or bee stings you should tell the doctor who is treating you that you are taking Captopril Oral Solution. In rare cases a serious allergic reaction can happen if you have desensitisation treatment whilst taking this medicine.
If you are about to have treatment for the removal of cholesterol from your blood by a machine (called LDL apheresis) you should tell your doctor you are taking Captopril Oral Solution. You may be given a different type of dialysis whilst taking this medicine.
Tell your doctor or nurse you are taking Captopril Oral Solution before you have any blood or urine tests as this medicine may interfere with the results of some tests.
If you are Afro-Caribbean you may require higher doses of Captopril Oral Solution to reduce your blood pressure.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This is because Captopril Oral Solution can affect the way some other medicines work.
In addition to this some other medicines can also affect the way Captopril Oral Solution works. It is especially important to tell your doctor if you are taking any of the following:
Your doctor may need to change your dose and/or to take other precautions:
If you are taking an angiotensin II receptor blocker (ARB) or aliskiren (see also information under the headings 'Do not take Captopril Oral Solution' and 'Warnings and precautions'.
Before surgery and anaesthesia (even at the dentist) you should tell your doctor or dentist that you are taking Captopril Oral Solution as there may be a sudden fall in your blood pressure.
You must tell your doctor if you think you are (or might become) pregnant. Your doctor will normally advise you to stop taking Captopril Oral Solution before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Captopril Oral Solution.
Captopril Oral Solution is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Tell your doctor if you are breast-feeding or about to start breast-feeding. Breast-feeding newborn babies (first few weeks after birth), especially premature babies, is not recommended whilst taking Captopril Oral Solution.
In the case of an older baby your doctor should advise you on the benefits and risks of taking Captopril Oral Solution whilst breast-feeding, compared with other treatments.
Captopril can affect your ability to drive, usually when you first start taking your medicine or if your doctor changes your dose. If you do feel lightheaded or dizzy when taking Captopril Oral Solution, you should not drive or use machinery.
Captopril 25mg/5ml Oral Solution contains 10.7mg sodium per maximum daily dose.
Captopril 5mg/5ml Oral Solution contains 53.4mg sodium per maximum daily dose.
To be taken into consideration by patients on a controlled sodium diet.
This medicine contains 0.5mg benzoate salt in each ml.
Captopril 25mg/5ml Oral Solution contains 15mg sodium benzoate per maximum daily dose.
Captopril 5mg/5ml Oral Solution contains 75mg sodium benzoate per maximum daily dose.
Sodium benzoate (E 211) may increase jaundice (yellowing of the skin and eyes) in newborn babies (up to 4 weeks old).
Captopril 25mg/5ml Oral Solution is recommended for daily doses of more than 25mg of captopril.
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
When you are taking Captopril Oral Solution, you should not change to using any different captopril containing medicines except under your doctor's supervision.
The 5mg/5ml product is supplied with the following administration devices:
5mg/5ml using 1mL syringe:
0.1mL = 0.1mg captopril
0.2mL = 0.2mg captopril
0.3mL = 0.3mg captopril
0.4mL = 0.4mg captopril
0.5mL = 0.5mg captopril
0.6mL = 0.6mg captopril
0.7mL = 0.7mg captopril
0.8mL = 0.8mg captopril
0.9mL = 0.9mg captopril
1.0mL = 1.0mg captopril
5mg/5ml using 5mL syringe:
1mL = 1mg captopril
1.25mL = 1.25mg captopril
2mL = 2mg captopril
2.5mL = 2.5mg captopril
3mL = 3mg captopril
3.75mL = 3.75mg captopril
4mL = 4mg captopril
5mL = 5mg captopril
The 25mg/5ml product is supplied with the following administration devices:
25mg/5ml using 5ml syringe:
1mL = 5mg captopril
1.25mL = 6.25mg captopril
2mL = 10mg captopril
2.5mL = 12.5mg captopril
3mL = 15mg captopril
3.75mL = 18.75mg captopril
4mL = 20mg captopril
5mL = 25mg captopril
25mg/5ml using cup:
5mL = 25mg captopril
7.5mL = 37.5mg captopril
10mL = 50mg captopril
12.5mL = 62.5mg captopril
15mL = 75mg captopril
17.5mL = 87.5mg captopril
20mL = 100mg captopril
22.5mL = 112.5mg captopril
25mL = 125mg captopril
27.5mL = 137.5mg captopril
30mL = 150mg captopril
Your doctor may start you on a lower dose. If you have a kidney disorder your doctor will increase the dose gradually until your blood pressure is adequately controlled up to a maximum of 150mg per day. The dosage may then be adjusted by your doctor to suit individual requirements.
The usual starting dose is 12.5 - 25mg twice a day. Your doctor may gradually increase this dose to 100 - 150mg a day. You may also need to be given other medicines to lower your blood pressure.
If you have kidney or heart problems or low levels of blood in your body you may be given a lower starting dose of 6.25mg or 12.5mg which may be gradually increased to 50mg -100mg a day.
The usual starting dose is 6.25 - 12.5mg two or three times a day. Your doctor may gradually increase this dose to a maximum of 150mg a day.
After a heart attack - short term treatment:
The usual starting dose is 6.25mg, which will then be gradually increased by your doctor to a maximum of 100mg a day.
After a heart attack - long term treatment:
The usual starting dose is 6.25mg, which will then be gradually increased by your doctor to a maximum of 150mg a day.
The usual dose is 75 - 100mg a day. Elderly patients are usually started on a dose of 6.25mg twice daily.
Your doctor will prescribe the most appropriate strength of Captopril Oral Solution according to the child's age, weight and dose.
Make sure that the correct amount is measured out. The starting dose is 0.3mg/kg body weight, divided into 3 equal doses daily. This may be increased gradually by the doctor.
The starting dose should be 0.15mg/kg body weight. Make sure that the correct amount is measured out.
You should try to take Captopril Oral Solution at about the same time every day. As food does not affect how captopril is absorbed, it can be taken before, during or after meals.
SHAKE WELL BEFORE USE.
Method of administration: Your doctor, pharmacist or nurse will show you how to administer this medicine.
The box containing the 5mg/5ml medicine will contain a 1ml dosing syringe, a 5ml dosing syringe, and a dosing adaptor.
The box containing the 25mg/5ml medicine will contain a 5ml dosing syringe, dosing adaptor and a 30ml dosing cup.
1ml syringe numbered increments are 0.1 ml and smaller increments are 0.01ml.
5ml syringe main numbered increments are 1, 2, 3, 4 and 5ml with additional numbers at 1.25, 2.5 and 3.75ml and smaller increments are 0.1ml
30ml dosing top - each numbered increment is 25ml.
See Dose measuring (Section 3.).
Instructions are provided below for using the dosing syringe. If you have any questions about the dose you should use or how to use the syringe, you should ask your pharmacist.
If you or anyone else takes too much Captopril Oral Solution you should go to your nearest hospital emergency department or tell your doctor immediately. Take the carton and bottle with any remaining solution you have with you.
If you miss a dose do not worry. Just carry on taking your normal dose when the next one is due. Do not take a double dose to make up for the one you missed.
You should not stop taking Captopril Oral Solution until your doctor tells you to, even if you feel well. If you feel you need to stop taking this medicine you should discuss this with your doctor before you stop taking it. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
Like all medicines, this medicine can cause side effects, although not everybody gets them. Some of these side effects will be noted by your doctor while monitoring your response and condition.
If you (or your child) experience any of the following reactions stop taking Captopril Oral Solution and contact your doctor IMMEDIATELY:
Common: May affect up to 1 in 10 people
Uncommon: May affect up to 1 in 100 people
Rare: May affect up to 1 in 1,000 people
Very Rare: May affect up to 1 in 10,000 people
If you or your child get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme. Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children. Do not refrigerate or freeze. Store below 25°C. Store in the outer carton, in order to protect from light. Use within 28 days of opening.
Do not use this medicine after the expiry date which is stated on the carton and bottle label. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste.
Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.
Each 25mg/5ml Oral Solution contains 25mg/5ml of the active substance captopril.
Each 5mg/5ml Oral Solution contains 5mg/5ml of the active substance captopril.
The other ingredients are mango flavour, disodium edetate, sodium benzoate (E211), citric acid (E330), sodium citrate (E331) and purified water. May also contain sodium hydroxide (E524) for pH adjustment. The mango flavour contains acacia gum, furaneol, acetaldehyde, farnesol, limonene and Carene.
Captopril Oral Solution is a clear, colourless solution supplied in 100ml amber glass bottles.
Each 25mg/5ml Oral Solution pack contains one bottle of solution, 5ml dosing syringe, a syringe adaptor to fit onto the bottle when measuring the dose and a 30ml dosing cup
Each 5mg/5ml Oral Solution pack contains one bottle of solution, 1ml and 5ml dosing syringes and a syringe adaptor to fit onto the bottle when measuring the dose.
This leaflet was last revised in 04/2021.
Other sources of information
To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge: 0800 198 5000 (UK only). Please be ready to give the following information:
Product name Reference number
Captopril 25mg/5ml Oral Solution PL 29831/0715
Captopril 5mg/5ml Oral Solution PL 29831/0714
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