Cycloserine 250 mg Hard Capsules

• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

1. What Cycloserine is and what it is used for
2. What you need to know before you take Cycloserine
3. How to take Cycloserine
4. Possible side effects
5. How to store Cycloserine
6. Contents of the pack and other information

• if you are allergic to cycloserine or any of the other ingredients of this medicine (listed in section 6). An allergic reaction may include rash, itching, difficulty breathing or swelling of the face, lips, throat or tongue
• if you have epilepsy
• if you suffer from depression
• if you have severe anxiety or psychosis (abnormal thoughts)
• if you have a severe kidney disease
• if you are an alcoholic.

Talk to your doctor or pharmacist before taking Cycloserine

• if you suffer from porphyria (a disorder affecting the red blood cells).

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

In particular, talk to your doctor if you are taking any of the following medicines:

• Ethioamide, isoniazid (for tuberculosis [TB]).

It may still be alright for you to be given Cycloserine and your doctor will be able to decide what is suitable for you.

Alcohol should be avoided whilst taking this medicine.

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Cycloserine has no effect on your ability to drive or use machines.

Sunset yellow FCF (E110) and carmoisine (E122) may cause allergic reactions.

Go to the nearest hospital casualty department or contact your doctor immediately. Take the carton with you.

If you miss a dose, take one as soon as you can. Do not take a double dose to make up for a forgotten dose. If you have missed several doses, tell your doctor.

All medicines can cause allergic reactions.

Tell your doctor straight away if you get any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching, especially affecting your whole body.

Reported side effects (the frequency cannot be estimated from available data)

• sudden shortness of breath (heart failure) – in patients receiving 4-6 capsules of cycloserine daily (1-1.5 g daily)
• coma
• headache
• feeling drowsy or very sleepy
• shaking
• dizziness
• confusion
• hallucination
• loss of memory
• slurred speech
• fits
• pins and needles in your hands and/or feet
• loss of use of your arms or legs
• twitching and muscle stiffness
• character and mood changes including feeling irritable and aggressive
• suicidal thoughts
• anemia
• abnormalities of liver function

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

• The active substance is cycloserine. Each hard capsule contains 250 mg of the active substance cycloserine.
• The other ingredients are: Talc, Erythrosin (E127), Carmoisine (E122) (see section 2), Sunset Yellow FCF (E110) (see section 2), Titanium Dioxide (E171), Black Iron Oxide (E172) and Gelatin.

Cycloserine capsules are red and grey and come in plastic bottles containing 100 capsules. Each bottle also contains a desiccant which has a label stating ‘Do not eat’.

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