• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

1. What Travoprost/Timolol is and what it is used for
2. What you need to know before you use Travoprost/Timolol
3. How to use Travoprost/Timolol
4. Possible side effects
5. How to store Travoprost/Timolol
6. Contents of the pack and other information

• if you are allergic to travoprost, timolol, or any of the other ingredients of this medicine (listed in section 6)
• if you are allergic to any prostaglandins or beta blockers
• if you have now or have had in the past respiratory problems such as asthma, severe chronic obstructive bronchitis (severe lung disease which may cause wheeziness, difficulty in breathing and/or long-standing cough) or other types of breathing problems
• if you have severe hay fever
• if you have a slow heartbeat, heart failure or disorder of heart rhythm (irregular heartbeat)
• if the surface of your eye is cloudy.

Ask your doctor for advice if any of these apply to you.

Talk to your doctor or pharmacist before using Travoprost/Timolol if you have now or have had in the past

• coronary heart disease (symptoms can include chest pain or tightness, breathlessness or choking), heart failure, low blood pressure
• disturbances of heart rate such as slow heart-beat
• breathing problems, asthma or chronic obstructive pulmonary disease
• poor blood circulation disease (such as Raynaud’s disease or Raynaud’s syndrome)
• diabetes, as timolol may mask signs and symptoms of low blood sugar
• overactivity of the thyroid gland as timolol may mask signs and symptoms of thyroid disease
• myasthenia gravis (chronic neuromuscular weakness)
• cataract surgery
• an eye inflammation.

If you need to have any type of surgery, tell your doctor that you are using Travoprost/Timolol as timolol may change the effects of some medicines used during anaesthesia.

If you get any severe allergic reaction (skin rash, redness and itching of the eye) while using Travoprost/Timolol, whatever the cause, adrenaline treatment may not be as effective. It is therefore important to tell the doctor that you are using Travoprost/Timolol when you are to receive any other treatment.

Travoprost/Timolol may change the colour of your iris (the coloured part of your eye). This change may be permanent.

Travoprost/Timolol may increase the length, thickness, colour and/or number of your eyelashes and may cause unusual hair growth on your eyelids.

Travoprost may be absorbed through the skin and therefore should not be used by women who are pregnant or are attempting to become pregnant. If any of the medicine comes into contact with the skin then it should be washed off straight away.

Travoprost/Timolol is not to be used by children and adolescents under 18 years of age.

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.

Travoprost/Timolol can affect or be affected by other medicines you are using, including other eye drops for the treatment of glaucoma. Tell your doctor if you are using or intend to use:

• medicines to lower blood pressure
• heart medicine including quinidine (used to treat heart conditions and some types of malaria)
• medicines to treat diabetes or antidepressants known as fluoxetine and paroxetine

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

Do not use Travoprost/Timolol if you are pregnant unless your doctor considers it necessary.

If you could get pregnant you must use adequate contraception whilst you use the medicine.

Do not use Travoprost/Timolol if you are breast-feeding. This medicine may get into your milk.

You may find that your vision is blurred for a time just after you use Travoprost/Timolol.

Travoprost /Timolol may also cause hallucinations, dizziness, nervousness or fatigue in some patients.

Do not drive or use machines until this has worn off.

This medicine contains 150 micrograms of benzalkonium chloride in each ml of solution.

Benzalkonium chloride may be absorbed by soft contact lenses and may change the colour of the contact lenses. You should remove contact lenses before using this medicine and put them back 15 minutes afterwards.

Benzalkonium chloride may also cause eye irritation, especially if you have dry eyes or disorders of the cornea (the clear layer at the front of the eye). If you feel abnormal eye sensation, stinging or pain in the eye after using this medicine, talk to your doctor.

Macrogolglycerol hydroxystearate 40 may cause skin reactions.

One drop in the affected eye or eyes, once a day in the morning or in the evening. Use at the same time each day.

Only use Travoprost/Timolol in both eyes if your doctor told you to do so. Use it for as long as your doctor told you to.

Only use Travoprost/Timolol for dropping in your eyes.

1

• Immediately before using a bottle for the first time, tear-off the sachet (picture 1). Take out the bottle and write the date of opening on the label in the space provided.
• Get the medicine bottle and a mirror.
• Wash your hands.
• Twist off the cap.

2

• Hold the bottle, pointing down, between your thumb and fingers.
• Tilt your head back. Pull down your eyelid with a clean finger, until there is a ‘pocket’ between the eyelid and your eye. The drop will go in here (picture 2).
• Bring the bottle tip close to the eye. Use the mirror if it helps.

3

• Do not touch your eye or eyelid, surrounding areas or other surfaces with the dropper. It could infect the drops.
• Gently squeeze the bottle to release one drop of medicine at a time (picture 3).

4

• After using the medicine, press a finger into the corner of your eye, by the nose for 2 minutes (picture 4). This helps to stop the medicine getting into the rest of the body.
• If you use drops in both eyes, repeat these same steps for your other eye.
• Close the bottle cap firmly immediately after use.
• Only use one bottle of medicine at a time. Do not open the sachet until you need to use the bottle.
• You must throw away the bottle 4 weeks after you first opened it, to prevent infections, and use a new bottle.

If a drop misses your eye, try again.

If you use more Travoprost/Timolol than you should, rinse it all out with warm water. Do not put in any more drops until it is time for your next regular dose.

If you forget to use Travoprost/Timolol, continue with the next dose as planned. Do not use a double dose to make up for a forgotten dose. The dose should not exceed one daily drop in the affected eye(s).

If you stop using Travoprost/Timolol without speaking to your doctor the pressure in your eye will not be controlled which could lead to loss of sight.

If you are using other eye drops in addition to Travoprost/Timolol, leave at least 5 minutes between putting in Travoprost/Timolol and the other drops.

If you wear soft contact lenses do not use the drops with your lenses in. After using the drops wait 15 minutes before putting your lenses back in.

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.

• The active substances are travoprost and timolol.
  Each ml of solution contains 40 micrograms of travoprost and 5 mg of timolol (as timolol maleate).
• The other ingredients are benzalkonium chloride, macrogolglycerol hydroxystearate 40, trometamol, edetate disodium, boric acid (E284), mannitol (E421), sodium hydroxide (for pH adjustment) and water for injection or purified water.

Travoprost/Timolol eye drops, solution is presented as a clear, colourless, aqueous solution, practically free from particles supplied in a 5 ml plastic bottle with colorless nozzle and white opaque cap with tamper proof seal.

Each bottle is enclosed in a sachet. Each bottle contains 2.5 ml solution.

The product is available in the following pack sizes:

Cartons containing 1 or 3 bottles.

Not all pack sizes may be marketed.