The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL 35533/0001.
Clopidogrel 75mg film-coated tablets
Clopidogrel 75mg film-coated tablets
1. What this medicine is and what it is used for
2. What you need to know before you take this medicine
3. How to take this medicine
4. Possible side effects
5. How to store this medicine
6. Contents of the pack and other information
Clopidogrel belongs to a group of medicines called antiplatelet medicines. Platelets are very small structures in the blood which clump together during blood clotting. By preventing this clumping, antiplatelet medicines reduce the chances of blood clots forming (a process called thrombosis).
Clopidogrel is taken by adults to prevent blood clots (thrombi) forming in hardened blood vessels (arteries), a process known as atherothrombosis, which can lead to atherothrombotic events (such as stroke, heart attack, or death).
You have been prescribed this medicine to help prevent blood clots and reduce the risk of these severe events because:
If you think any of these apply to you, or if you are in any doubt at all, consult your doctor before taking this medicine.
If any of the situations mentioned below apply to you, talk to your doctor before taking this medicine:
While you are taking this medicine:
Do not give this medicine to children because it does not work.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription. Some other medicines may influence the use of clopidogrel or vice versa.
You should specifically tell your doctor if you take:
If you have experienced severe chest pain (unstable angina or heart attack), transient ischaemic attack or ischaemic stroke in mild severity, you may be prescribed this medicine in combination with aspirin, a substance present in many medicines used to relieve pain and lower fever. An occasional use of aspirin (no more than 1,000mg in any 24 hour period) should generally not cause a problem, but prolonged use in other circumstances should be discussed with your doctor.
This medicine may be taken with or without food.
It is preferable not to take this medicine during pregnancy.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. If you become pregnant while taking this medicine, consult your doctor immediately as it is recommended not to take clopidogrel while you are pregnant.
You should not breast-feed while taking this medicine. If you are breast-feeding or planning to breast-feed, talk to your doctor before taking this medicine.
Ask your doctor or pharmacist for advice before taking any medicine.
Clopidogrel is unlikely to affect your ability to drive or to use machines.
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
The recommended dose, including for patients with a condition called ‘atrial fibrillation’ (an irregular heartbeat), is one 75mg tablet of Clopidogrel per day to be taken orally with or without food, and at the same time each day.
If you have experienced severe chest pain (unstable angina or heart attack), your doctor may give you 300mg or 600mg of Clopidogrel (4 or 8 tablets of 75mg) once at the start of treatment. Then, the recommended dose for adults, including the elderly, is one 75mg tablet of Clopidogrel per day as described above.
If you have experienced symptoms of a stroke which go away within a short period of time (also known as transient ischaemic attack) or an ischaemic stroke mild in severity, your doctor may give you 300mg of Clopidogrel (4 tablets of 75mg) once at the start of treatment. Then, the recommended dose is one 75mg tablet of this medicine per day as described above with acetylsalicylic acid for 3 weeks. Following this your physician will prescribe either Clopidogrel alone or acetylsalicylic acid alone.
You should take this medicine for as long as your doctor continues to prescribe it.
Contact your doctor or the nearest hospital emergency department because of the increased risk of bleeding.
If you forget to take a dose of this medicine, but remember within 12 hours of your usual time, take your tablet straightaway and then take your next tablet at the usual time.
If you forget for more than 12 hours, simply take the next single dose at the usual time. Do not take a double dose to make up for a forgotten tablet.
Do not stop the treatment unless your doctor tells you so. Contact your doctor or pharmacist before stopping.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
The most common side effect reported with this medicine is bleeding. Bleeding may occur as bleeding in the stomach or bowels, bruising, haematoma (unusual bleeding or bruising under the skin), nose bleed, blood in the urine. In a small number of cases, bleeding in the eye, inside the head, the lung or the joints has also been reported.
If you cut or injure yourself, it may take longer than usual for bleeding to stop. This is linked to the way your medicine works as it prevents the ability of blood clots to form. For minor cuts and injuries e.g., cutting yourself, shaving, this is usually of no concern. However, if you are concerned by your bleeding, you should contact your doctor straightaway (see section 2 ‘Warnings and precautions’).
In addition, your doctor may identify changes in your blood or urine test results.
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.
You can also report side effects directly via the Yellow Card Scheme (website: www.mhra.gov.uk/yellowcard) or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. The expiry date refers to the last day of that month.
Store below 25°C.
Do not use this medicine if you notice any visible signs of deterioration.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
The active substance is clopidogrel. Each film-coated tablet contains 75mg of clopidogrel (as besilate).
The other ingredients are:
Tablet core: Microcrystalline cellulose (E460), Mannitol (E421), Hydroxypropylcellulose (E463), Crospovidone (E1202), Citric acid monohydrate (E330), Macrogol 6000 (E1521), Stearic acid (E570), Talc (E553b).
Tablet coating: Hypromellose (E464), Lactose monohydrate, Iron oxide red (E172), Triacetin (E1518), Titanium dioxide (E171).
Clopidogrel film-coated tablets are pink, round and biconvex. They are supplied in PVC/PE/PVDC/Aluminium blisters packed in cartons containing 14, 28, 30, 50, 56, 84, 90, 98, 100 film-coated tablets.
Not all pack sizes may be marketed.
Marketing Authorisation Holder:
This leaflet was last revised in: 12/2023