Clonidine hydrochloride 100 micrograms/ 5 ml Oral Solution.

• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

The name of your medicine is Clonidine hydrochloride 100 micrograms/ 5 ml Oral Solution but it will be referred to as ‘Clonidine hydrochloride’ throughout this leaflet.

1. What Clonidine hydrochloride is and what it is used for
2. What you need to know before you take Clonidine hydrochloride
3. How to take Clonidine hydrochloride
4. Possible side effects
5. How to store Clonidine hydrochloride
6. Contents of the pack and other information

• If you are pregnant, likely to get pregnant or are breast feeding
• If you are allergic (hypersensitive) to clonidine or any of the other ingredients of this medicine (listed in section 6).
• This medicine should not be used by children and adolescents below 18 years of age
• If you have a slow heart rate due to heart problems
• If you are already taking other medicines that contain clonidine

Do not take this medicine if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before using Clonidine hydrochloride.

Talk to your doctor, pharmacist or nurse before taking Clonidine hydrochloride if:

• You have Raynaud’s disease (a problem with circulation to the fingers and toes) or other blood circulation problems, including circulation to the brain
• You have heart or kidney problems
• You have or have ever had depression
• You have constipation
• You have a nerve disorder that causes your hands and feet to feel different (‘altered sensation’) or low blood pressure when you stand up.

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Clonidine hydrochloride.

As you may get dry eyes whilst taking this medicine, this may be a problem if you wear contact lenses.

This medicine should not be used in children or adolescents under 18 years of age.

Tell to your doctor or pharmacist if you are taking or have recently taken or might take any other medicines. This includes medicines that you buy without a prescription and herbal medicines. This is because Clonidine hydrochloride can affect the way some other medicines work. Also some other medicines can affect the way Clonidine hydrochloride works.

In particular, tell your doctor or pharmacist if you are taking any of the following medicines:

• Other medicines that make you drowsy
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as ibuprofen
• Medicines for depression such as imipramine or mirtazapine
• Medicines for severe mental illness such as schizophrenia. These are also known as ‘antipsychotics’ and include chlorpromazine

Please also tell your doctor or pharmacist if you are taking any of the following medicines for high blood pressure or other heart problems:

• Beta blockers such as atenolol
• Water tablets (‘diuretics’) such as furosemide
• Alpha blockers such as prazosin or doxazosin. These can also be used for prostate problems in men
• Vasodilators such as diazoxide or sodium nitroprusside
• Calcium antagonists such as verapamil or diltiazem hydrochloride
• ACE inhibitors such as captopril or lisinopril
• Digitalis glycosides such as digoxin

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Clonidine hydrochloride.

If you are having any blood tests, tell the person giving the test that you are taking this medicine. This is because Clonidine hydrochloride can affect results relating to your liver.

If you are going to have an operation, keep taking your Clonidine hydrochloride unless your doctor tells you otherwise. If you need to go into hospital, take the bottle of oral solution with you.

You may feel drowsy while taking Clonidine hydrochloride. Drinking alcohol while taking Clonidine hydrochloride can make this worse.

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Taking Clonidine hydrochloride is not recommended if you are pregnant, likely to get pregnant or breast-feeding.

You may feel drowsy, dizzy or could have some disturbances of vision. If affected, you should not drive, operate machinery or take part in any activities where these may put you or others at risk.

Methyl parahydroxybenzoate (E218), which may cause allergic reactions (possibly delayed).

Sodium: This medicine contains less than 1mmol sodium (23 mg) per 5 ml, that is to say essentially ‘sodium-free’.

• The usual starting dose is between 2.5 ml (50 micrograms) and 5 ml (100 micrograms) of oral solution, three times a day
• If necessary, your doctor will gradually increase the dose
• Most people’s blood pressure is controlled by taking between 15 ml (300 micrograms) and 60 ml (1200 micrograms) of oral solution daily, in divided dosese

This medicine is not recommended for use in children and adolescents below 18 years

This medicine must be taken orally.

Use the measuring syringe provided in the pack to deliver the required dose.

a) Open the bottle: press the cap and turn it anticlockwise (figure 1). Separate the adaptor from the syringe (figure 2).

b) Insert the adaptor into the bottle neck (figure 3). Ensure it is properly fixed. Take the syringe and put it in the adaptor opening (figure 4).

c) Turn the bottle upside down. Fill the syringe with a small amount of solution by pulling the piston down (figure 5A), then push the piston upwards in order to remove any possible bubble (figure 5B). Pull the piston down to the graduation mark corresponding to the quantity in millilitres (ml) prescribed by your doctor (figure 5C).

d) Turn the bottle the right way up (figure 6A). Remove the syringe from the adaptor (figure 6B).

e) Empty the contents of the syringe into the patient’s mouth by pushing the piston to the bottom of the syringe (figure 7). The contents of the syringe should be emptied into the side cheek of the patient's mouth to avoid a choking hazard. Close the bottle with the plastic screw cap. Wash the syringe with water (figure 8).

If you take more Clonidine hydrochloride than you should, talk to a doctor or go to a hospital straight away. Take the medicine pack with you, even if there is no medicine left.

If you forget a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten dose.

Do not stop taking Clonidine hydrochloride without first talking to your doctor. If you have been using this medicine for a long time, you may feel agitated when you stop taking it. This is called a ‘withdrawal effect’.

If you get any side effects, talk to your doctor,pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme, Website: www.mhra.gov.uk/yellowcard, or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

The active substance is clonidine hydrochloride.

Each 5ml of oral solution contains 100micrograms of clonidine hydrochloride.

The other ingredients are: methyl parahydroxybenzoate (E218), sodium dihydrogen phosphate monohydrate (E339), disodium phosphate (E339), sucralose (E955) and purified water.

Clonidine hydrochloride is a clear colourless solution, supplied in an amber glass bottle, with a tamper evident, child resistant white plastic cap with a 10ml oral syringe with 0.25ml graduation mark for measuring and administering the dose and a syringe adaptor.

Clonidine hydrochloride is supplied in a bottle containing150ml oral solution.