Blood and lymphatic system disorders
Agranulocytosis, leucopenia, haemolytic anaemia, thrombocytopenia.
Cardiac disorders
Tachycardia, palpitations, arrhythmias.
Eye disorders
Blurred vision, oculogyric crisis.
Gastrointestinal disorders
Dryness of the mouth, nose and throat, constipation, increased gastric reflux.
Nausea, vomiting, diarrhoea stomach pain.
Loss of appetite.
General disorders and administration site conditions
Asthenia.
Hepatobiliary disorders
Hepatic dysfunction, hypersensitivity hepatitis, cholestatic jaundice and cholestatic hepatitis have occurred in association with cyclizine.
Immune system disorders
Hypersensitivity reactions, including anaphylaxis have occurred.
Musculoskeletal and connective tissue disorders
Twitching, muscle spasms.
Nervous system disorders
Effects on the central nervous system have been reported with cyclizine these include restless leg syndrome, somnolence, drowsiness, incoordination, headache, dystonia, dyskinesia, extrapyramidal motor disturbances, tremor, convulsions, dizziness, decreased consciousness, transient speech disorders, paraesthesia and generalised chorea.
Ear and labyrinth disorders
Tinnitus.
Psychiatric disorders
Disorientation, restlessness, nervousness, euphoria, insomnia and auditory and visual hallucinations have been reported, particularly when dosage recommendations have been exceeded.
Renal and urinary disorders
Urinary retention.
Respiratory, thoracic and mediastinal disorders
Bronchospasm, apnoea.
Skin and subcutaneous tissue disorders
Urticaria, drug rash, angioedema, allergic skin reactions, fixed drug eruption, photosensitivity.
Vascular disorders
Hypertension, hypotension.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme, website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.