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The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL 14894/0790.
Diavic 6 mg/ml solution for injection in pre-filled pen
Diavic 6 mg/ml solution for injection in pre-filled pen
liraglutide
1. What Diavic is and what it is used for
2. What you need to know before you use Diavic
3. How to use Diavic
4. Possible side effects
5. How to store Diavic
6. Contents of the pack and other information
Diavic contains the active substance liraglutide. It helps your body reduce your blood sugar level only when blood sugar is too high. It also slows food passage through your stomach and can help prevent heart disease.
Diavic is used on its own if your blood sugar is not properly controlled by diet and exercise alone, and you cannot use metformin (another diabetes medicine).
Diavic is used with other medicines for diabetes when they are not enough to control your blood sugar levels. These may include:
Talk to your doctor, pharmacist or nurse:
This medicine should not be used if you have type 1 diabetes (your body does not produce any insulin) or diabetic ketoacidosis (a complication of diabetes with high blood sugar and increase in effort to breathe). It is not an insulin and should therefore not be used as a substitute for insulin.
The use of Diavic is not recommended if you are on dialysis.
The use of Diavic is not recommended if you have severe liver disease.
The use of Diavic is not recommended if you have severe heart failure.
This medicine is not recommended if you have a severe stomach or gut problem which results in delayed stomach emptying (called gastroparesis), or inflammatory bowel disease.
If you have symptoms of acute pancreatitis, such as persistent, severe stomach ache, you should consult your doctor immediately (see section 4).
If you have thyroid disease including thyroid nodules and enlargement of the thyroid gland, consult your doctor.
When initiating treatment with Diavic, you may in some cases experience loss of fluids/dehydration, e.g. in case of vomiting, nausea and diarrhoea. It is important to avoid dehydration by drinking plenty of fluids. Contact your doctor if you have any questions or concerns.
Diavic can be used in adolescents and children aged 10 years and above. No data are available in children below 10 years of age.
Please tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take any other medicines.
In particular, tell your doctor, pharmacist or nurse if you are using medicines containing any of the following active substances:
Tell your doctor if you are, you think you might be, or are planning to become pregnant. Diavic should not be used during pregnancy because it is not known if it may harm your unborn child.
It is not known if Diavic passes into breast milk, therefore do not use this medicine if you are breast-feeding.
Low blood sugar (hypoglycaemia) may reduce your ability to concentrate. Avoid driving or using machines if you experience signs of hypoglycaemia. Please see section 4 for the warning signs of low blood sugar. Please consult your doctor for further information on this topic.
This medicine contains less than 1 mmol sodium (23 mg) per dose. This means that it is essentially ‘sodium free’.
Always use this medicine exactly as your doctor has told you. Check with your doctor, pharmacist or nurse if you are not sure.
Diavic is given as an injection under the skin (subcutaneous). Do not inject it into a vein or muscle. The best places to give yourself the injection are the front of your thighs, the front of your waist (abdomen), or your upper arm.
You can give yourself the injection at any time of the day, regardless of meals. When you have found the most convenient time of the day it is preferred that you inject Diavic around the same time of the day.
Before you use the pen for the first time, your doctor or nurse will show you how to use it. Detailed instructions for use are provided on the other side of this leaflet.
If you use more Diavic than you should, talk to your doctor straight away. You may need medical treatment. You may experience nausea, vomiting, diarrhoea or low blood sugar (hypoglycaemia). Please refer to section 4 for warning signs of low blood sugar.
If you forget a dose, use Diavic as soon as you remember.
However, if it is more than 12 hours since you should have used Diavic, skip the missed dose. Then take your next dose as usual the following day.
Do not take an extra dose or increase the dose on the following day to make up for the missed dose.
Do not stop using Diavic without talking to your doctor. If you stop using it, your blood sugar levels may increase.
If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Common: may affect up to 1 in 10 people
Rare: may affect up to 1 in 1,000 people
Very rare: may affect up to 1 in 10,000 people
Very common: may affect more than 1 in 10 people
Common
When initiating treatment with Diavic, you may in some cases experience loss of fluids/dehydration, e.g. in case of vomiting, nausea and diarrhoea. It is important to avoid dehydration by drinking plenty of fluids.
Uncommon: may affect up to 1 in 100 people
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the pen label and carton after ‘EXP’. The expiry date refers to the last day of that month.
Before opening:
Store in a refrigerator (2°C–8°C). Do not freeze. Store away from the freezer compartment.
During use:
You can keep the pen for 1 month when stored at a temperature below 30°C or in a refrigerator (2°C– 8°C), away from the freezer compartment. Do not freeze.
When you are not using the pen, keep the pen cap on in order to protect from light.
Do not use this medicine if the solution is not clear and colourless or almost colourless.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
Diavic is supplied as a pre-filled pen, with a light blue body and a dose button, and a yellow dose selector with grey pen cap. Each pen contains 3 ml of solution, delivering 30 doses of 0.6 mg, 15 doses of 1.2 mg or 10 doses of 1.8 mg.
Diavic is available in packs containing 1, 2, 3, 5 or 10 pens.
Not all pack sizes may be marketed. Needles are not included.
Marketing Authorisation Holder:
Manufacturers:
This leaflet was last revised in April 2023.
Please read these instructions carefully before using your pen.
Your pen comes with 18 mg of liraglutide. You can select doses of 0.6 mg, 1.2 mg or1.8 mg.
The pen is designed to be used with disposable injection needles up to a length of 8 mm and as thin as 32G (0.25/0.23 mm) such as outer needle cap, inner needle cap, needle, paper tab.
A Check the name and coloured label of your pen to make sure that it contains liraglutide. Using the wrong medicine could cause severe harm.
Pull off the pen cap.
B Pull off the paper tab from a new disposable needle. Screw the needle straight and tightly onto your pen.
C Pull off the outer needle cap and keep it for later.
D Pull off the inner needle cap and dispose of it.
Always use a new needle for each injection. This reduces the risk of contamination, infection, leakage of liraglutide, blocked needles and inaccurate dosing.
Be careful not to bend or damage the needle.
Never try to put the inner needle cap back on the needle. You may stick yourself with the needle.
Important information
Check the flow before your first injection with each new pen. If your pen is already in use, go to ‘Select your dose’, step H.
E Turn the dose selector until the flow check symbol lines up with the pointer.
F Hold the pen with the needle pointing up. Tap the cartridge gently with your finger a few times. This will make any air bubbles collect at the top of the cartridge.
G Keep the needle pointing up and press the dose button until 0 mg lines up with the pointer.
A drop of liraglutide should appear at the needle tip. If no drop appears, repeat steps E to G up to four times.
If there is still no drop of liraglutide, change the needle and repeat steps E to G once more.
Do not use the pen if a drop of liraglutide still does not appear. This indicates the pen is defective and you must use a new one.
If you have dropped your pen against a hard surface or suspect that something is wrong with it, always put on a new disposable needle and check the flow before you inject.
Always check that the pointer lines up with 0 mg.
H Turn the dose selector until your needed dose lines up with the pointer (0.6 mg, 1.2 mg or 1.8 mg).
If you selected a wrong dose by mistake, simply change it by turning the dose selector backwards or forwards until the right dose lines up with the pointer.
Be careful not to press the dose button when turning the dose selector backwards, as liraglutide may come out.
If the dose selector stops before your needed dose lines up with the pointer, there is not enough liraglutide left for a full dose. Then you can either:
Split your dose into two injections:
Turn the dose selector in either direction until 0.6 mg or 1.2 mg lines up with the pointer. Inject the dose. Then prepare a new pen for injection and inject the remaining number of mg to complete your dose.
You may only split your dose between your current pen and a new pen if trained or advised by your healthcare professional. Use a calculator to plan the doses. If you split the dose wrong, you may inject too much or too little liraglutide.
Inject the full dose with a new pen:
If the dose selector stops before 0.6 mg lines up with the pointer, prepare a new pen and inject the full dose with the new pen.
Do not try to select other doses than 0.6 mg, 1.2 mg or 1.8 mg. The numbers in the display must line up precisely with the pointer to ensure that you get the correct dose.
The dose selector clicks when you turn it. Do not use these clicks to select your dose.
Do not use the cartridge scale to measure how much lliraglutide to inject – it is not accurate enough.
I Insert the needle into your skin using the injection technique shown by your doctor or nurse. Then follow the instructions below:
Press the dose button to inject until 0 mg lines up with the pointer. Be careful not to touch the display with your other fingers or press the dose selector sideways when you inject. This is because it may block the injection.
Keep the dose button pressed down and leave the needle under the skin for at least 6 seconds. This is to make sure that you get your full dose.
J Pull out the needle.
After that, you may see a drop liraglutide at the needle tip.
This is normal and does not affect your dose.
K Guide the needle tip into the outer needle cap without touching the needle or the outer needle cap.
L When the needle is covered, carefully push the outer needle cap completely on. Then unscrew the needle. Dispose of it carefully and put the pen cap back on.
When the pen is empty, carefully dispose of it without a needle attached. Please dispose of the pen and needle in accordance with local requirements.
Always remove the needle after each injection, and store your pen without a needle attached.
This reduces the risk of contamination, infection, leakage of liraglutide, blocked needles and inaccurate dosing.
Caregivers must be very careful when handling used needles – to prevent needle injury and cross-infection
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