Adrenaline (Epinephrine) Injection BP 1 in 1000

Adrenaline Injection BP 1 in 1000 may be used in the treatment of acute allergy and anaphylactic shock.

Intramuscular (IM) adrenaline is recommended by the Resuscitation Council UK as the first line treatment for anaphylaxis in all healthcare settings. The patient should be monitored as soon as possible (i.e. pulse, blood pressure, ECG, pulse oximetry). This will help monitor the patient's response to adrenaline.

The best site for IM injection is the anterolateral aspect of the middle third of the thigh. The needle used for injection needs to be sufficiently long to ensure that the adrenaline is injected into muscle.

The following doses of Adrenaline (Epinephrine) Injection BP 1 in 1000 are recommended:

Hypersensitivity to adrenaline, sodium metabisulfite or to any of the excipients listed in section 6.1.

Adrenaline 1 in 1000 should not be used in fingers, toes, ears, nose or genitalia owing to the risk of ischaemic tissue necrosis.

Adrenaline should be used with caution in patients with:

• hyperthyroidism, psychoneurosis, phaeochromocytoma, narrow angle glaucoma, diabetes mellitus, hypokalaemia or hypercalcaemia.

• severe renal impairment, prostatic hypertrophy or urination difficulty

• cerebrovascular disease, organic brain damage or arteriosclerosis

• autonomic dysreflexia (hyperreflexia), particularly in spinal cord injury (e.g. tetraplegics)

• shock (other than anaphylactic shock)

• organic heart disease or cardiac dilatation (severe angina pectoris, obstructive cardiomyopathy, hypertension) as well as most patients with arrhythmias. Anginal pain may be induced when coronary insufficiency is present.

Adrenaline should be used with caution in older patients.

In patients with Parkinson's disease, adrenaline may be associated with a transient worsening of Parkinson's symptoms such as rigidity and tremor.

Adrenaline should be used with extreme caution in patients with long-standing bronchial asthma and emphysema who have developed degenerative heart disease.

Adrenaline should be used cautiously, if at all, during general anaesthesia with halogenated hydrocarbon anaesthetics (See section 4.5).

Adrenaline should not be used during the second stage of labour (See Section 4.6).

Accidental intravascular injection may result in cerebral haemorrhage due to the sudden rise in blood pressure.

Use of adrenaline with drugs that may sensitise the heart to arrhythmias, e.g., digitalis, or quinidine, ordinarily is not recommended.

Adrenaline (Epinephrine) Injection BP 1:1000 (1mg/ml) is not suitable for IV use.

The IM route is generally preferred in the initial treatment of anaphylaxis, the IV route is generally more appropriate in the Intensive Care Unit (ICU) or Emergency Department (ED) setting. Adrenaline (Epinephrine) Injection BP 1:1000 (1mg/ml) is not suitable for IV use. If the epinephrine 1:10,000 (0.1 mg/ml) injection is not available, epinephrine injection 1:1000 must be diluted to 1:10,000 before IV use. The IV route for injection of epinephrine must be used with extreme caution and is best reserved for specialists familiar with IV use of epinephrine (adrenaline) in an appropriate setting.

Monitor the patient as soon as possible (pulse, blood pressure, ECG, pulse oximetry) in order to assess the response to adrenaline.

Repeated injections of Adrenaline can cause necrosis as a result of vascular constriction at the injection site. Tissue necrosis may also occur in the extremities, kidneys and liver. Intramuscular injections of Adrenaline into the buttocks should be avoided because of the risk of tissue necrosis.

Pallor can occur following adrenaline administration, due to vasoconstriction. This might be misinterpreted as ongoing cardiovascular compromise or anaphylaxis and thereby can increase the risk of adrenaline overdose. This is a particular concern in small children, who may remain pale following 2–3 doses of adrenaline. A significantly raised blood pressure is a key indicator of adrenaline overdose.

The subcutaneous route for adrenaline is not recommended for treatment of an anaphylaxis as it is less effective.

Prolonged use of Adrenaline can result in severe metabolic acidosis (because of elevated blood concentrations of lactic acid), renal necrosis and tachyphylaxis.

Adrenaline Injection contains sodium metabisulfite, which can cause allergic-type reactions, including anaphylaxis and life-threatening or less severe asthmatic episodes, in certain susceptible individuals.

The presence of sodium metabisulfite in parenteral Adrenaline and the possibility of allergic-type reactions should not deter use of the drug when indicated for the treatment of serious allergic reactions or for other emergency situations.

Sympathomimetic agents:

Adrenaline should not be administered concomitantly with other sympathomimetic agents because of the possibility of additive effects and increased toxicity.

Alpha-adrenergic agents:

The vasoconstrictor and pressor effects of adrenaline, mediated by its alpha-adrenergic action, may be enhanced by concomitant administration of drugs with similar effects, such as ergot alkaloids or oxytocin.

Alpha-adrenergic blocking agents:

Alpha-blockers such as phentolamine antagonise the vasoconstriction and hypertension effects of adrenaline. This effect may be beneficial in adrenaline overdose (See section 4.9). Adrenaline specifically reverses the antihypertensive effects of adrenergic neurone blockers such as guanethidine with the risk of severe hypertension.

Beta-adrenergic blocking agents:

Severe hypertension and reflex bradycardia may occur with non-cardioselective beta-blocking agents such as propranolol, due to alpha-mediated vasoconstriction.

Beta-blockers, especially non-cardioselective agents, also antagonise the cardiac and bronchodilator effects of adrenaline. Patients with severe anaphylaxis who are taking non-cardioselective beta-blockers may not respond to adrenaline treatment.

General Anaesthetics:

Administration of Adrenaline in patients receiving halogenated hydrocarbon general anaesthetics that increase cardiac irritability and seem to sensitise the myocardium to Adrenaline may result in arrhythmias including ventricular premature contractions, tachycardia or fibrillation (See section 4.4).

Antihypertensive agents:

Adrenaline specifically reverses the antihypertensive effects of adrenergic neurone blockers such as guanethidine, with the risk of severe hypertension. Adrenaline increases blood pressure and may antagonise the effects of antihypertensive drugs.

Antidepressant agents:

Tricyclic antidepressants such as imipramine inhibit reuptake of directly acting sympathomimetic agents, and may potentiate the effect of adrenaline, increasing the risk of development of hypertension and cardiac arrhythmias.

Concurrent use or use within 2 weeks of a monoamine oxidase inhibitor increases the risk of adverse events.

Phenothiazines:

Phenothiazines block alpha-adrenergic receptors (see above).

Adrenaline should not be used to counteract circulatory collapse or hypotension caused by phenothiazines; a reversal of the pressor effects of Adrenaline may result in further lowering of blood pressure.

Other drugs:

Adrenaline should not be used in patients receiving high dosage of other drugs (e.g. cardiac glycosides) that can sensitise the heart to arrhythmias.

Some antihistamines (e.g. diphenhydramine, chlorphenamine) and thyroid hormones may potentiate the effects of Adrenaline, especially on heart rhythm and rate.

Adrenaline increases the risk of cardiac adverse effects of levodopa.

Use of catechol-O-methyl transferase inhibitors (COMT inhibitors) such as Entacapone may potentiate the chronotropic and arrhythmogenic effects of adrenaline.

Hypokalaemia:

The hypokalaemic effect of adrenaline may be potentiated by other drugs that cause potassium loss, including corticosteroids, potassium-depleting diuretics, aminophylline and theophylline.

Hyperglycaemia:

Adrenaline-induced hyperglycaemia may lead to loss of blood-sugar control in diabetic patients treated with insulin or oral hypoglycaemic agents.

Pregnancy

Adrenaline crosses the placenta. There is some evidence of a slightly increased evidence of congenital abnormalities. Injection of adrenaline may cause anoxia to the foetus, foetal tachycardia, cardiac irregularities, extrasystoles and louder heart sounds.

Adrenaline usually inhibits spontaneous or oxytocin induced contractions of the pregnant human uterus and may delay the second stage of labour. In dosage sufficient to reduce uterine contractions, the drug may cause a prolonged period of uterine atony with haemorrhage. For this reason parenteral Adrenaline should not be used during the second stage of labour.

Adrenaline should only be used during pregnancy if the potential benefits justify the possible risks to the foetus.

Breastfeeding:

Breast-feeding Adrenaline is distributed into breast milk. Adrenaline is not orally bioavailable; any adrenaline excreted in breast milk would not be expected to have any effect on the nursing infant.

Fertility:

As adrenaline is a substance that naturally occurs in the body, it is unlikely that this drug would have any detrimental effects on fertility.

Patients' ability to drive and use machines may be affected by the anaphylactic reaction, as well as by possible adverse reactions to adrenaline.

The adverse events of adrenaline mainly relate to the stimulation of both alpha- and beta-adrenergic receptors. The occurrence of undesirable effects depends on the sensitivity of the individual patient and the dose involved.

Immune system disorders:

Anaphylaxis, possibly with severe bronchospasm (See section 4.4).

Metabolism and nutrition disorders:

Hypokalaemia, metabolic acidosis (see section 4.4).

Inhibition of insulin secretion and hyperglycaemia even with low doses, gluconeogenesis, glycolysis, lipolysis and ketogenesis.

Psychiatric disorders:

Psychotic states, anxiety, fear, confusion, irritability, insomnia, restlessness

Nervous system disorders:

Headache, dizziness, tremors

In patients with Parkinsonian Syndrome, Adrenaline increases rigidity and tremor.

Subarachnoid haemorrhage and hemiplegia have resulted from hypertension, even following subcutaneous administration of usual doses of Adrenaline.

Cardiac disorders:

Disturbances of cardiac rhythm and rate may result in palpitation and tachycardia. Adrenaline can cause potentially fatal ventricular arrhythmias including fibrillation, especially in patients with organic heart disease or those receiving other drugs that sensitise the heart to arrhythmias. Angina, myocardial ischaemia and myocardial infarction have been reported.

Adrenaline causes E.C.G. changes including a decrease in T-Wave amplitude in all leads in normal subjects.

In rare cases stress cardiomyopathy has been seen in patients treated with adrenaline.

Vascular disorders:

Hypertension (with risk of cerebral haemorrhage).

Coldness of extremities may occur even with small doses of Adrenaline.

Bowel necrosis

Respiratory disorders:

Dyspnoea. Pulmonary oedema may occur after excessive doses or in extreme sensitivity.

Gastrointestinal disorders:

Dry mouth, reduced appetite, nausea, vomiting, hypersalivation.

Renal and urinary disorders:

Difficulty in micturition, urinary retention.

General disorders and administrative site conditions:

Sweating, weakness, pallor.

Repeated injections of Adrenaline can cause necrosis as a result of vascular constriction at the injection site. Tissue necrosis may also occur in the extremities, kidneys and liver.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store

Symptoms

After overdosage or inadvertent intravenous administration of usual intramuscular subcutaneous doses of Adrenaline, systolic and diastolic blood pressure rise sharply; venous pressure also rises. Cerebrovascular or other haemorrhages and hemiplegia may result, especially in elderly patients. Pulmonary oedema may occur.

Adrenaline overdosage causes transient bradycardia followed by tachycardia and may cause other potentially fatal cardiac arrhythmias. Kidney failure, metabolic acidosis and cold white skin may also occur.

Treatment

Because Adrenaline is rapidly inactivated in the body, treatment of acute toxicity is mainly supportive.

The pressor effects of Adrenaline may be counteracted by an immediate intravenous injection of a quick-acting alpha-adrenoreceptor blocking agent, such as 5-10 mg of phentolamine mesylate, followed by a beta-adrenoreceptor blocking agent, such as 2.5 - 5 mg of propranolol. Arrhythmias, if they occur, may be counteracted by propranolol injection.

Pharmacotherapeutic group: adrenergic and dopaminergic agents, adrenaline.

ATC code: C01 CA 24

Adrenaline is a naturally occurring catecholamine secreted by the adrenal medulla in response to exertion or stress. It is a sympathomimetic amine which is a potent stimulant of both alpha- and beta-adrenergic receptors and its effects on target organs are therefore complex. It is used to provide rapid relief of hypersensitivity reactions to allergies or to idiopathic or exercise-induced anaphylaxis.

Adrenaline has a strong vasoconstrictor action through alpha- adrenergic stimulation. This activity counteracts the vasodilatation and increased vascular permeability leading to loss of intravascular fluid and subsequent hypotension, which are the major pharmacological features in anaphylactic shock.

Adrenaline stimulates bronchial beta-adrenergic receptors and has a powerful bronchodilator action. Adrenaline also alleviates pruritus, urticaria and angioedema associated with anaphylaxis.

There is large inter-individual variability in the response to adrenaline, with peak absorption occurring around 5-10 min after intramuscular injection. Its absorption from the intramuscular site is faster and more reliable than from the subcutaneous site..

Adrenaline is rapidly inactivated in the body, mostly in the liver by the enzymes catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO). Much of a dose of adrenaline is excreted as metabolites in urine. The plasma half-life is about 2-3 minutes. However, when given by subcutaneous or intramuscular injection, local vasoconstriction may delay absorption so that the effects may last longer than the half-life suggests.

No further information other than that which is included in the Summary of Product Characteristics.

Sodium Metabisulfite Ph. Eur.

Sodium Chloride Ph. Eur.

Sodium Hydroxide Ph. Eur.

Water for Injections Ph. Eur.

Hydrochloric Acid Ph. Eur.

Adrenaline is rapidly denatured by oxidising agents and alkalis including sodium bicarbonate, halogens, nitrates, nitrites and salts of iron, copper and zinc. Adrenaline may be mixed with 0.9% Sodium Chloride injection but is incompatible with 5% sodium chloride injection. The stability of Adrenaline in 5% dextrose injection decreases when the pH is greater than 5.5.

15 months

Do not store above 25 °C.

Keep container in the outer carton in order to protect from light.

Clear glass ampoules of 1 ml. Packed in cardboard cartons to contain 10 ampoules x 1 ml.

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