Proposed changes are:

• removal of the patient information brochure from the educational material, following

the PRAC assessment report PSUSA/00010635/202303

• removal of the black symbol and explanatory statements for medicinal products subject

to additional monitoring

• aligned terminology with the RMP for the term "immune-related" versus "immunemediated.

• additional editorial changes introduced by MAH.

Please find attached latest approved Patient alert card with marked changes and in clean

version.