Atropine sulfate 1 mg/5 ml, solution for injection in pre-filled syringe must be administered under medical supervision.
Posology:
Pre-anaesthetic medication
Intravenous administration immediately before surgery; if necessary an intramuscular administration 30-60 minutes before surgery is possible.
Adults:
0.3 0.6 mg IV or IM (1.5 3 ml)
In combination with neostigmine to limit its muscarinic effects: Adults:
0.6-1.2 mg IV (3 to 6 ml)
Treatment of hemodynamically compromising bradycardia, atrioventricular block, cardiopulmonary resuscitation:
Adults:
- Sinus bradycardia: 0.5 mg IV (2.5 ml), every 2-5 minutes until the desired heart rate is achieved.
- AV block: 0.5 mg IV (2.5 ml), every 3-5 minutes (maximum 3 mg)
As an antidote to organophosphates (pesticides, nerve gases), to cholinesterase inhibitors and in muscarinic mushroom poisoning:
Intravenous use.
Adults:
0.5 - 2 mg atropine sulfate (2.5 - 10 ml) depending on the patient's features and response, can be repeated after 5 minutes and subsequently as required, until signs and symptoms disappear (this dose may be exceeded many times).
Dose adjustments
In general, dosage should be adjusted according to patient's response and tolerance.
Dosage to a total maximum dose of 3 mg in adults is usually increased until adverse effects become intolerable; then a slight reduction in dosage generally yields the maximum dosage tolerated by the patient.
Special populations
Caution is advised for patients with renal or hepatic impairment and in elderly (see section 4.4).
Method of administration
Atropine is administered by intravenous injection or intramuscular injection.
Paediatric population
The pre-filled syringe is not adapted to the administration in paediatric population; the graduation does not permit accurate measurement.