This information is intended for use by health professionals
Guaifenesin Ph Eur
Ammonium chloride Ph. Eur.
Ammonium carbonate HSE
For the relief of chesty coughs and colds on the chest.
For oral administration.
Adults and children over 12 years: 10ml
The dose should be taken with twice its volume of water three or four times in 24 hours.
Children under 12 years: Not recommended
Elderly: The normal adult dose is still appropriate in the elderly.
Hypersensitivity to any of the ingredients.
If symptoms persist consult your doctor.
Keep all medicines out of the reach of children.
No clinically significant interactions.
The safety of this product during pregnancy has not been established, although there is no good evidence of an association between first trimester exposure to either ammonium chloride or guaiphenesin and foetal abnormalities. The safety of the product during lactation has not been established, although use during this period would not be considered to constitute a hazard.
No adverse effects known.
May occasionally produce gastrointestinal discomfort, nausea and vomiting.
Symptoms of overdosage include nausea, vomiting, thirst, headache, hyperventilation and progressive drowsiness, leading to profound acidosis and hypokalaemia.
Treatment consists of the correction of acidosis and electrolyte loss by the intravenous administration of sodium bicarbonate or sodium lactate, together with potassium supplements by mouth. Otherwise treatment should be symptomatic and supportive.
Ammonium chloride and ammonium carbonate have an irritant effect on mucous membranes and are considered to have expectorant properties.
Guaiphenesin is thought to reduce the viscosity of tenacious sputum and has expectorant properties.
Ammonium salts are effectively absorbed from the gastrointestinal tract. The ammonium ion is converted into urea in the liver; the anion thus liberated into the bloodstream and extracellular fluid causes a metabolic acidosis and decreases the pH of the urine, this is followed by a transient diuresis.
Guaiphenesin is absorbed from the gastrointestinal tract. It is metabolised and excreted in the urine.
There are no preclinical data of relevance to the prescriber which are additional to that already included.
Liquorice flavour 15020064 IFF
White flint or amber glass bottle with a rolled-on pilfer-proof neck finish. The bottle is fitted with a child-resistant polypropylene cap with LDPE liner
Pack size: 200ml
The Boots Company PLC
1 Thane Road West
Nottingham NG2 3AA
Date first granted: 1 June 1973