What is a Patient Information Leaflet and why is it useful?

The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged.

Below is a text only representation of the Patient Information Leaflet. The original leaflet can be viewed using the link above.

The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL 12762/0599.


Prochlorperazine Injection BP 12.5mg/ml, 2ml

Package leaflet: Information for the user

Prochlorperazine Mesilate 12.5mg/ml Solution for Injection

READ ALL OF THIS LEAFLET CAREFULLY BEFORE YOU START TAKING THIS MEDICINE. BECAUSE IT CONTAINS IMPORTANT INFORMATION FOR YOU.

Keep this leaflet. You may need to read it again.

If you have any further questions, ask your doctor, pharmacist or nurse. If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

The name of your medicine is Prochlorperazine Mesilate 12.5mg/ml Solution for Injection. It will be referred to as Prochlorperazine Injection for ease hereafter.

What is in this leaflet:

1. What Prochlorperazine Injection is and what it is used for
2. What you need to know before you take Prochlorperazine Injection
3. How to take Prochlorperazine Injection
4. Possible side effects
5. How to store Prochlorperazine Injection
6. Contents of the pack and other information

1. WHAT PROCHLORPERAZINE INJECTION IS AND WHAT IT IS USED FOR

Prochlorperazine Injection belongs to a class of drugs called phenothiazine neuroleptics. It influences the activity of certain brain cells by decreasing the effect of dopamine, a natural chemical in the brain.

Prochlorperazine Injection may be used to improve the symptoms of major mental disorders such as in schizophrenia, acute mania, and short term treatment of anxiety. It may also be used to treat the symptoms of nausea (feeling sick) and vomiting (being sick), as well as symptoms of vertigo due to Menieres syndrome or labyrinthitis (inner ear disorders).

2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE PROCHLORPERAZINE INJECTION

Do not take Prochlorperazine Injection if:

  • you are allergic to Prochlorperazine Mesilate or any of the other ingredients of this medicine (listed in section 6)
  • the person is a child. This is because children may develop unusual face and body movements (dystonic reactions).

Warnings and precautions

Talk to your doctor or pharmacist or nurse before taking Prochlorperazine Injection

  • If you suffer from any disease involving the heart and blood vessels (cardiovascular disease) including chest pain (angina) and irregular heart beats
  • If you have a problem with your liver or kidneys
  • If you have high blood pressure due to a tumour of a gland situated on top of the kidney (a condition known as phaeochromocytoma)
  • If you suffer from a brain disorder causing tremors, rigidity and slowing of movement (Parkinson’s disease)
  • you suffer from fits (epilepsy)
  • If you suffer from an eye disease called narrow angle glaucoma which causes increased pressure inside the eye
  • If you have or have ever had a low number of white blood cells (agranulocytosis). This would lead you to get infections more easily than usual
  • If you have ever had a stroke
  • If you have dementia
  • If you have low blood levels of potassium, calcium and magnesium. Your doctor may perform blood tests to check on these
  • If you are not eating properly or are very underweight
  • If you have a history of alcohol problems
  • If you have depression
  • If you are diabetic or have high levels of sugar in your blood (hyperglycaemia). Your doctor may want to monitor you more closely
  • If you have abnormal muscle weakness (Myasthenia gravis)
  • If you suffer from an enlargement of prostate gland (which will result in difficulty in passing water)
  • If you are exposed to extremes in temperature as this medicine can affect body temperature control
  • If you have an underactive thyroid gland
  • If you are an elderly person
  • If you or someone else in your family has a history of blood clots, as medicines like these have been associated with formation of blood clots.

Other medicines and Prochlorperazine Injection:

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. The effects of these medicines may change, especially if you are taking:

  • sleeping tablets or sedatives (e.g. phenobarbital) that can make you sleepy
  • medicines which result in lowering of blood pressure or treat migraine (e.g. guanethidine or clonidine)
  • anticholinergic medicines for stomach problems or used to reduce saliva and lung secretions (e.g. atropine, procyclidine)
  • antidepressants (e.g. other phenothiazines, lithium)
  • medicines for fits (anticonvulsants)
  • medicines for Parkinson’s disease (e.g. levodopa)
  • medicines for asthma or to relieve a stuffy nose or used in eye drops (adrenaline or sympathomimetic drugs)
  • medicines used to treat diabetes
  • medicines used to treat iron poisoning (desferrioxamine)
  • antacids used to treat indigestion
  • medicines used to control heart beat such as propranolol
  • medicines used for the treatment of cancer (cytotoxics)
  • medicines used for infection (antibiotics)
  • amfetamines used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).

Prochlorperazine Injection with food, drink and alcohol:

You should not drink alcohol whilst you are taking this medicine.

Pregnancy breast feeding and fertility:

You should not be given Prochlorperazine Injection if you are pregnant, think you may be pregnant or are planning to become pregnant, or while breast feeding, unless your doctor decides that treatment is essential. It is particularly important not to take Prochlorperazine Injection during the first three months of pregnancy.

The following symptoms may occur in newborn babies, of mothers that have used Prochlorperazine in the last trimester (last three months of their pregnancy): shaking, muscle stiffness and/or weakness, sleepiness, agitation, breathing problems and difficulty in feeding. If your baby develops any of these symptoms you may need to contact your doctor.

Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines:

Prochlorperazine Injection may make you feel drowsy or dizzy or give you blurred vision. You should not drive or use machines when you are first given this medicine until you are certain that you are not getting these side effects. If in any doubt, speak to your doctor before you drive or use machines.

Prochlorperazine Injection contains sodium, sodium sulphite and sodium metabisulphite:

This medicinal product contains less than 1mmol sodium (23mg) per dose, i.e. is essentially “sodium-free”.

This medicine also contains the preservatives sodium sulphite (E221) and sodium metabisulphite (E223) which may rarely cause severe hypersensitivity reactions and bronchospasm.

3. HOW TO TAKE PROCHLORPERAZINE INJECTION

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Prochlorperazine Injection is only given in the hospital by a doctor.

Prochlorperazine Injection is usually given by injection deep into the muscle. Your doctor will decide on a suitable dose depending on your age, severity of the symptoms and previous responses to similar medicines.

For mood disorders and schizophrenia, it may take several weeks for you to feel the full benefit of this medicine.

Elderly

A smaller starting dose should be given to elderly patients.

Use in children and adolescents

Prochlorperazine Injection is not for use in children.

If you are given more Prochlorperazine Injection than you should:

As Prochlorperazine Injection is administered by a healthcare professional it is unlikely that you will be given too much. If you are at all concerned, speak to your doctor.

In this event, you will be treated in the hospital and you will be given the necessary treatment.

If you miss a dose of Prochlorperazine Injection:

This is unlikely as the injection is given by a healthcare professional but if you are concerned about missing a dose, speak to your doctor.

4. POSSIBLE SIDE EFFECTS

Like all medicines, this medicine can cause side effects, although not everybody gets them.

You should avoid:

  • Exposure to direct sunlight (or sunbeds) if you are receiving a high dose of this medicine as it could cause your skin to over react to sunlight. Your doctor may advise you to use a sunblock
  • Getting the injection solution on your skin as it could cause a type of skin rash (dermatitis).

Some patients may experience a local lump at the site of injection, difficulty in sleeping, stuffy nose or dry mouth, agitation.

Tell your doctor straight away if you notice any of the following:

  • Very rarely, patients may experience a fast or irregular heartbeat, constipation, difficulty or inability to pass urine or a high temperature
  • Rarely, Prochlorperazine Injection can lead to breast enlargement in men or to inappropriate milk production or altered menstrual cycle (e.g. periods stop) or lowered sexual performance
  • Occasionally, some patients have complained of feeling slowed down, whilst others of being agitated
  • Feeling weak or light-headed, especially just after standing up (this commonly occurs just after the injection has been administered)
  • A problem with your breathing
  • Very occasionally, medicines such as Prochlorperazine Injection can have effects on muscle control. If this happens, symptoms can include slurred speech, odd movements of the face, particularly of the tongue, eyes, head or neck (such as twisting of the neck which causes an unnatural positioning of the head, rigid muscles, tremors or restlessness and difficulty in sitting still. Some patients (especially on high doses of this medicine) experience problems with muscle control which may continue for years. Such patients may experience constant chewing or tongue movements or other gentle movements of the neck, head or trunk. Uncontrollable movements of the arms and legs have also been reported in these patients
  • In elderly people with dementia, a small increase in the number of deaths has been reported for patients taking antipsychotics compared with those not receiving antipsychotics
  • Rarely patients may develop Neuroleptic Malignant Syndrome. This causes a high temperature, rigid muscles, drowsiness, occasional loss of consciousness, and requires emergency admission to hospital for treatment
  • If you have angina and your pain is getting worse
  • There have been very rare reports of jaundice (yellowing of skin and whites of eyes) eye problems, skin colouring (pigmentation) and blood problems
  • If you suffer from a sore throat, high fever, feel very tired, become pale, develop bruises and nose bleeds. Fever may occur 1-3 weeks after treatment. These may indicate blood problems developing as a result of using this medicine
  • Tremor, rigidity, slowed ability to start and continue movements, and impaired ability to adjust the body's position
  • High blood sugar (symptoms can include excessive thirst, passing large amounts of urine, weight loss and feeling very tired)
  • Blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing. If you notice any of these symptoms seek medical advice immediately.

If any of the side effects become serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store

By reporting side effects you can help provide more information on the safety of this medicine.

5. HOW TO STORE PROCHLORPERAZINE INJECTION

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the ampoule and carton. The expiry date refers to the last day of that month.

Do not store above 25°C. Keep ampoules in the outer carton in order to protect from light.

If only part of the solution is used, the remainder should be discarded.

6. CONTENTS OF THE PACK AND OTHER INFORMATION

The active substance in Prochlorperazine Injection is prochlorperazine mesilate.

The other ingredients are anhydrous sodium sulphite (E221), sodium metabisulphite (E223) and ethanolamine in water for injections.

What Prochlorperazine Injection looks like and contents of the pack:

Prochlorperazine Injection is a colourless or almost colourless sterile solution. Each 1ml of solution contains 12.5mg of prochlorperazine mesilate. The solution is presented in 1ml and 2ml clear glass ampoules.

Each carton contains either 5 or 10 ampoules. Not all pack sizes may be marketed.

Marketing Authorisation Holder:

Mercury Pharmaceuticals Ltd
Capital House
85 King William Street
London
EC4N 7BL
UK

Manufacturer:

B. Braun Melsungen AG
Mistelweg 2
12357 Berlin
Germany

This leaflet was last revised in September 2019.

LF-117886-01