Summary of Product Characteristics Updated 01-Jul-2020 | hameln pharma ltd
Adults (including elderly) and Children:
Potassium Chloride Concentrate 20% must be diluted by adding to a large volume of intravenous fluid before use. For example, 10mls diluted with not less than 700mls 0.9% Sodium Chloride Intravenous Infusion BP, or other suitable diluent, and mixed well.Dosage depends on the serum ionogram value and the acid-base state. A potassium deficiency is calculated according to the formula:MMOL Potassium = KG BW x 0.2 x 2 x (4.5 actual serum potassium (MMOL)).(The extracellular volume is calculated from the body weight in kg x 0.2).The maximum dosage is 20 MMOL potassium per hour.It is recommended not to exceed 2-3 MMOL potassium per kg body weight in 24 hours.Potassium sparing diuretics:
Potassium supplements should not be administered with potassium- sparing diuretics (such as amiloride, spironolactone and triamterene), particularly in patients with impaired renal function. Any patients on this combination require close monitoring in order to diagnose a potential hyperkalaemic condition as soon as possible.Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists:
Patients taking ACE-inhibitors or angiotensin II receptor antagonists, especially those with impaired renal function, should be closely monitored, as the potassium sparing effect in combination with potassium infusion may result in hyperkalaemia.Ciclosporin:
Concurrent use of ciclosporin may increase the risk of hyperkalaemia.Glucose Infusion:
Concomitant use of glucose infusions in hypokalaemic patients may cause a further decrease in plasma potassium concentrations.Use as directed by a physician.
hameln pharma ltd
Nexus, Gloucester Business Park,
Gloucester, GL3 4AG,
UK
PL 01502/0015R
30th August 2001
01/04/2020
Nexus, Gloucester Business Park, Gloucester, GL3 4AG, UK
+44 (0)1452 621 661
https://www.hameln-pharma.com
+44 (0)1452 632 732