- calcium glycerophosphate
- potassium glycerophosphate
- manganese glycerophosphate
- sodium glycerophosphate
GSL: General Sales List
This information is intended for use by health professionals
Adults and children 12 years and over:Oral. One or two 5 ml spoonfuls, preferably diluted, two or three times daily before meals.Maximum daily dose: 30 ml
Children aged 6 years and over:Oral. One 5 ml spoonful, preferably diluted, two or three times daily before meals.Maximum daily dose: 15 ml
Children under 6 yearsMetatone is not suitable for administration to children under six years of age, except under the advice of a physician.
The Elderly:Normal adult dosage is appropriate.
Reporting of suspected adverse reactionsReporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.
Symptoms and signsWhen taken orally, thiamine is non-toxic. If large doses are ingested they are not stored by the body but excreted unchanged by the kidneys.Excessive amounts of calcium, sodium and potassium salts may lead to hypercalcaemia, hypernatraemia and hyperkalaemia, respectively.Manganese salts are poorly absorbed. TreatmentTreatment should be symptomatic and supportive.
Vitamin B1Vitamin B1 is essential for proper carbohydrate metabolism and plays an essential role in the decarboxylation of alpha keto acids. Vitamin B1 deficiency may lead to the clinical condition known as Beri-Beri.
GlycerophosphatesGlycerophosphates were introduced on the grounds that lecithin contains phosphorus in the form of the glycerophosphate radical and that glycerophosphates would therefore be a source of phosphorus that would be more easily assimilated by the tissues, particularly by the brain. Phosphorus is essential for most metabolic processes. As calcium phosphate, phosphorus is a major constituent of bones and teeth. In addition phosphates are a major constituent of all oils and as adenosine phosphates, play an essential role in energy liberation and utilisation.
CalciumCalcium is a major component of bones and teeth and is necessary for the clotting of blood, the integrity of many cells, especially those of the neuromuscular system and for cardiac function. The consequence of decreased calcium levels in its extreme includes convulsions, tetany, behavour and personality disorders, mental growth retardation and bone deformities, the most common being rickets in children and osteomalacia in adults.
ManganeseManganese is required for the synthesis of the mucopolysaccharides of cartilage, glucose utilisation, steroid biosynthesis and for the activity of pyruvate carboxylase.
Sodium and PotassiumSodium is present as the sodium ion in all body fluids and in particular in extracellular fluids, whilst potassium as the potassium ion is largely present intracellulary. Together, sodium and potassium control many cellular events, with a critical role in maintaining fluid balance and in muscle and nerve activity.
Vitamin B1Vitamin B1 is well absorbed in the gastro-intestinal tract. An active transport process is involved. After absorption, Vitamin B1 is widely distributed to all tissues and appears in the foetal circulation during pregnancy; active transfer is involved. Vitamin B1 appears in breast milk at concentrations which are dependent on the maternal serum levels.Vitamin B1 is not stored to an appreciable extent, and excess is excreted, unchanged, together with the products of hepatic metabolism, in the urine.
CalciumIn the digestive tract, the total quantity of calcium available for absorption is augmented by the calcium in intestinal secretions. Calcium is incompletely absorbed from the gut and normally, depending on the intake, 70 - 80% of calcium from the diet is excreted in the faeces.
ManganeseLittle information is available on the pharmacokinetics of manganese, however, presumably, sufficient of this trace element is absorbed from the G.I. tract to maintain health in normal individuals.
Sodium and PotassiumDietary sodium and potassium are readily absorbed and excessive amounts are excreted mainly via the kidneys.