This information is intended for use by health professionals
Kaolin and Morphine Mixture BP
Irradiated light kaolin BP
Morphine Hydrochloride Ph Eur
A slowly separating buff suspension with the odour and taste of chlorodyne.
For the relief of occasional diarrhoea.
For oral administration.
Adults and children over 12 years: 10ml (two teaspoonfuls) in water.
May be repeated three times a day until the condition is relieved.
Children under 12 years: Not recommended for children under 12 years.
Elderly: There is no need for dosage reduction in the elderly.
Hypersensitivity to any of the ingredients. Respiratory depression, acute alcoholism, head injuries and conditions in which there is raised intracranial pressure. Impaired liver function.
Should be used with caution in patients with inflammatory or obstructive bowel disorders.
Keep all medicines out of the reach of children.
Warning: Do not exceed the stated dose.
If diarrhoea does not stop in 24 hours, talk to your doctor.
Suitable for the symptomatic relief of diarrhoea only. No substitute for rehydration therapy. Drink plenty of fluids if you have diarrhoea.
May cause drowsiness. If affected do not drive or operate machinery.
Clinically significant interactions may occur in patients taking maoi's concurrently or within 14 days of such treatment and these reactions may be serious. The depressant effects of morphine may enhance depressants of the central nervous system such as alcohol, hypnotics, sedatives and phenothiazines. The absorbent properties of kaolin may influence the gastrointestinal absorption of other drugs.
The safety of kaolin and morphine during pregnancy and lactation has not been established, though no special precautions are thought necessary provided the recommended dose is taken.
Kaolin and morphine mixture may cause drowsiness in certain individuals and may therefore interfere with the ability to drive or operate machinery.
Common side effects which may occur include nausea, vomiting, constipation, drowsiness, dry mouth, sweating, facial flushing and miosis.
Symptoms of overdosage may include nausea, vomiting, drowsiness, confusion, dry mouth, sweating, facial flushing, bradycardia, palpitations, orthostatic hypotension and miosis. Respiratory depression, circulatory failure, deepening coma and convulsions may also occur.
Treatment consists of emptying the stomach by aspiration and lavage. A saline purgative such as sodium sulphate, 30g in 250ml of water may be given to aid peristalsis.
The specific narcotic antagonist naloxone may be used to rapidly counteract the respiratory depression and coma. Otherwise treatment should be symptomatic and supportive.
Light kaolin is absorbent and when given orally absorbs toxic and other substances from the gastrointestinal tract and increases the bulk of the faeces.
Morphine in small doses increases tone and contraction in both the small and large bowel without analgesic effect and thereby delays intestinal transit.
Kaolin is not absorbed from the gastrointestinal tract. Morphine is absorbed from the gastrointestinal tract and undergoes significant first pass metabolism in the liver. Morphine is widely distributed.
Metabolism occurs in the liver, principally to morphine 3- and 6- glucuronides, although smaller amounts of morphine undergo n-demethylation and o-methylation. About 10% of morphine is secreted in the bile and eliminated in the faeces, while the remainder is excreted in the urine, mainly as conjugates.
Liquorice liquid extract
A 2000ml amber-coloured glass bottle with a wadless polypropylene cap.
A 200ml amber-coloured glass bottle, screwneck and a pilfer-proof aluminium roll-on cap with a PVC flowed in liner or triseal (LDPE/EPE/LDPE) liner.
The Boots Company PLC
1 Thane Road West
Nottingham NG2 3AA
Trading as: BCM