Sterile Concentrate for Cardioplegia Infusion
Each ml of solution contains 0.163g Magnesium Chloride Hexahydrate Ph Eur, 0.060g Potassium Chloride Ph Eur and 0.014g Procaine Hydrochloride Ph Eur.
Sterile Concentrate for Cardioplegia Infusion is used during heart surgery to induce cardioplegia.
Solution for infusion into the coronary arteries during cardiopulmonary bypass to induce cardioplegia.
A sterile aqueous solution for dilution. 20 ml are diluted with 1 litre of Compound Sodium Chloride Injection BPC, immediately before use.
Hypersensitivity to procaine
The contents of one (20 ml) ampoule must be diluted with 1 litre of Compound Sodium Chloride Injection BPC, immediately before use.
Appropriate supportive measures should be taken.
Apnoea: It may be necessary to apply artificial respiration
For circulatory depression: Give a vasopressor and intravenous fluids.
For seizures: Give oxygen and intravenous diazepam.
For methaemoglobinaemia: Give oxygen and methylene blue
At the concentration produced after diluting the product, magnesium chloride increases conduction time and the PR and QRS intervals are lengthened. Elevated potassium levels have significant effects on electrical activity in the heart. The T waves become increased in height, the PR interval lengthens and the P wave disappears as potassium concentration increases. The Procaine hydrochloride acts as a local anaesthetic. The primary site of action for procaine is the myocardium, resulting in a decrease in electrical excitability, conduction rate and force of contraction.
Procaine hydrochloride is almost completely metabolised with only about 2% excreted unchanged in the urine. The half life is less than one minute.
Acute toxicity data for procaine hydrochloride indicates an LD50
of 200 mg/kg following oral administration in the Rat. There are no other additional preclinical safety data that would be of significance to the prescriber.
Disodium Edetate BP
Water for Injections BP
Do not store above 25°C.
Protect from light
Clear colourless Ph Eur type I glass ampoules containing 20 ml of solution.
The ampoules are packed in cartons of 10.
Macarthy's Laboratories Ltd
T/a Martindale Pharmaceuticals