What is a Patient Information Leaflet and why is it useful?

The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged.

Below is a text only representation of the Patient Information Leaflet. The original leaflet can be viewed using the link above.

The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL20417/0107 .

Heparin sodium 10 IU/ml IV flush solution


Heparin sodium 10 IU/ml I.V. flush solution

heparin sodium

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet. You may need to read it again.
  • If you have any further questions ask your doctor, pharmacist or nurse.
  • If any of the side effects become serious, or you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
  • If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

What is in this leaflet

1. What Heparin flush is and what it is used for
2. What you need to know before you use Heparin flush
3. How to use Heparin flush
4. Possible side effects
5. How to store Heparin flush
6. Contents of the pack and other information


Heparin flush belongs to a group of medicines called anticoagulants. It helps to stop the blood from clotting.

Heparin flush is given into an intravenous (I.V.) line. This means it is injected into the tube connected to a vein to keep it clear by preventing the blood from clotting in it. It is not recommended for treatment of harmful blood clots in your body.


Do not have Heparin flush

  • If you are allergic (hypersensitive) to heparin or any of the other ingredients in your medicine. You can find a list of these ingredients in section 6 of this leaflet.
  • If you know that you have, or have ever had, a big drop in the clotting cells (platelets) in your blood, caused by having any type of heparin (reaction called heparin-induced thrombocytopenia).

Take special care with Heparin flush

Before you have Heparin flush, tell your doctor:

  • If you are allergic (hypersensitive) to low molecular weight heparins, such as tinzaparin, enoxaparin or dalteparin.

If you have Heparin flush regularly for more than five days, your doctor may take regular blood tests. This is to check the level of platelets (a type of cell) in your blood while you have your medicine. Depending on the result the doctor may tell you to stop having this medicine straight away.

Taking other medicines

Please tell your doctor or pharmacist if you are taking, or have recently taken any other medicines. This includes any medicines which you have bought without a prescription.

Pregnancy and breast-feeding

If you are pregnant or might be pregnant, tell your doctor before you are given Heparin flush.

If you become pregnant while having this medicine, tell your doctor.

If you are breast-feeding, ask your doctor for advice before having Heparin flush.

Driving and using machines

Usually your medicine may have little effect on your ability to drive or use machines. However, you should check with your doctor if you feel any side effect that may stop you from driving or using machines.

Important information about some of the ingredients of Heparin flush

This medicine contains:

  • Sodium. This medicine is nearly “sodium free”.

Your medicine contains less than 23 milligrams (mg) of sodium in each 10 International Units (IU) dose. Please ask your doctor if you are worried about any of the ingredients in this medicine.


Heparin flush will be given to you by a doctor or nurse.

Heparin flush should not be mixed with any other injection.

The recommended dose of Heparin Flush is

For routine use, 1-5 ml (10-50 IU heparin) should be administered into the catheter/cannula every 4 to 8 hours or as required. Your doctor will prescribe the right dose for you.

If you take more Heparin Flush than you should:

You may start to haemorrhage (bleed severely). Please read section 4 so you can spot any signs this may be happening to you.

You may be given another injection of a medicine called protamine sulphate.

If you have any further questions about taking this medicine, please ask your doctor or pharmacist.


When used as recommended the low dose of heparin reaching the blood is unlikely to have any effects on the body. However, information is given here on possible side effects.

Important side effects to look out for

You must get urgent medical help if you have any of the following symptoms. You may be having an allergic reaction:

  • You have difficulty breathing, wheezing
  • Your face or throat swell
  • Your skin develops a severe rash
  • Hives
  • Fever, chills
  • Swelling of eyes and lips
  • You develop blue tinge to the lips

You should tell your doctor straight away if you spot any of the following signs which mean you may be starting to bleed severely:

  • Red or brown urine
  • Black tarry stools
  • Unusual bruising
  • Bleeding from your nose, mouth or any operation wound that will not stop.

Other possible side effects

  • Bruising or bleeding more easily. Your blood may also form harmful clots. A big drop in clotting cells (platelets) in your blood may give you these symptoms. Your doctor can explain this more.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed on this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.


  • Keep out of the sight and reach of children.
  • Do not use Heparin flush after the expiry date on the label. The expiry date is the last day of that month. Once opened, any of the solution not used at once should be discarded.
  • Store below 25°C.

Medicines should not be thrown away in waste water or in household waste. Please ask your pharmacist how to throw away any medicine you do not need anymore. If you do this you will help protect the environment.


What Heparin flush contains

  • The active ingredient is heparin sodium.
    This product contains 10 IU of heparin sodium in each millilitre (ml).
  • The other ingredients are sodium chloride and water for injections

You can find important information about some of the ingredients near the end of section 2, just before section 3.

What Heparin flush looks like and contents of the pack

Heparin flush is a clear, colourless or pale yellow liquid. This medicine comes in glass ampoules containing 5 ml. There are 10 ampoules in a carton.

Marketing Authorisation Holder and Manufacturer responsible for batch release:

Fannin (UK) Limited
DCC Vital
Westminster Industrial Estate
Repton Road
DE12 7DT

This leaflet was last revised in June 2018.