Patient Leaflet Updated 27-Aug-2026 | Zentiva
Lutonaze 137 micrograms/50 micrograms per actuation, Nasal Spray, Suspension
Lutonaze 137 micrograms/50 micrograms per actuation,
nasal spray, suspension
azelastine hydrochloride/fluticasone propionate
1. What Lutonaze nasal spray is and what it is used for
2. What you need to know before you use Lutonaze nasal spray
3. How to use Lutonaze nasal spray
4. Possible side effects
5. How to store Lutonaze nasal spray
6. Contents of the pack and other information
The name of your medicine is Lutonaze 137 micrograms /50 micrograms per actuation, nasal spray, suspension (called Lutonaze nasal spray throughout this leaflet). It contains two active substances: azelastine hydrochloride and fluticasone propionate.
Lutonaze nasal spray is used to relieve the symptoms of moderate to severe seasonal and perennial allergic rhinitis if the use of either intranasal antihistamine or corticosteroid alone is not considered sufficient.
Seasonal and perennial allergic rhinitis are allergic reactions to substances such as pollen (hayfever), house mites, moulds, dust or pets. Lutonaze nasal spray relieves the symptoms of allergies, for example: runny nose, post nasal drip, sneezing and itchy or blocked nose.
Talk to your doctor or pharmacist before using Lutonaze nasal spray if you:
In these cases your doctor will decide whether you can use Lutonaze nasal spray.
It is important that you take your dose as stated in section 3 below or as advised by your doctor. Treatment with higher than recommended doses of nasal corticosteroids may result in adrenal suppression, a condition that may produce weight loss, fatigue, muscle weakness, low blood sugar, salt cravings, joint pains, depression and darkening of the skin. If this happens your doctor may recommend another medicine during periods of stress or elective surgery.
To avoid adrenal suppression your doctor will advise you to take the lowest dose at which effective control of your symptoms of rhinitis is maintained.
Taking nasal corticosteroids (such as Lutonaze nasal spray) may, when taken for a long time, cause children and adolescents to grow more slowly. The doctor will check your child’s height regularly, and make sure he or she is taking the lowest possible effective dose.
Contact your doctor, if you experience blurred vision or other visual disturbances.
If you are unsure whether the above applies to you, talk to your doctor or pharmacist before using Lutonaze nasal spray.
This medicine is not recommended for children under 12 years.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Some medicines may increase the effects of Lutonaze nasal spray and your doctor may wish to monitor you carefully if you are taking these medicines (including some medicines for HIV: ritonavir, cobicistat and medicines for the treatment of fungal infections: ketoconazole).
If you are pregnant or breast feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.
Lutonaze nasal spray has a minor influence on the ability to drive and use machines.
Very rarely, you may experience fatigue or dizziness due to the disease itself or when using Lutonaze nasal spray. In these cases, do not drive or operate machinery. Please be aware that drinking alcohol may enhance these effects.
This medicine contains 2.3 mg of benzalkonium chloride in each bottle.
Benzalkonium chloride may cause irritation or swelling inside the nose, especially if used for a long time.
Tell your doctor or pharmacist if you feel discomfort when using the spray.
Each actuation (0.14 g) contains less than 1 mmol (23 mg) sodium, that is to say essentially “sodium-free”.
Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
It is essential to use Lutonaze nasal spray regularly to gain the full therapeutic benefit.
Contact with the eyes should be avoided.
The recommended dose is one spray into each nostril in the morning and evening.
This medicine is not recommended for children under 12 years.
There are no data in patients with renal and hepatic impairment.
For nasal use.
Read the following instructions carefully and use only as directed.
Preparing the spray
1. Shake the bottle gently for 5 seconds by tilting it upwards and downwards and then remove the protective cap.
2. The first time the nasal spray is used, you must prime the pump by spraying it into the air.
3. Prime the pump by putting two fingers on either side of the spray pump and place your thumb on the bottom of the bottle.
4. Press down and release the pump 6 times until a fine mist appears (see figure a).
5. Now your pump is primed and ready to use.
6. If the nasal spray has not been used for more than 7 days, you will need to re-prime the pump once by pressing down and releasing the pump.
Using the spray
1. Shake the bottle gently for 5 seconds by tilting it upwards and downwards and then remove the protective cap
2. Blow your nose to clear your nostrils.
3. Keep your head tilted downwards towards your toes. Do not tilt head backwards.
4. Hold the bottle upright and carefully insert the spray tip into one nostril.
5. Close other nostril with your finger, rapidly press down once and sniff gently at the same time (see figure b).
6. Breathe out through your mouth.
7. Repeat in your other nostril.
8. Breathe in gently, and do not tilt your head back after dosing. This will stop the medicine going into your throat and causing an unpleasant taste.
9. After each use, wipe the spray tip with a clean tissue or cloth and then replace the protective cap.
10. If you think the nozzle may be blocked, don’t use a pin or anything sharp to clear it. Clean the spray tip with water.
It is important that you take your dose as advised by your doctor. You should use only as much as your doctor recommends.
Lutonaze nasal spray is suitable for long-term use. The duration of treatment should correspond to the period of experiencing allergy symptoms.
If you spray too much of this medicine into your nose you are unlikely to have any problems. If you are worried or if you have used doses higher than recommended over a long period, contact your doctor. If anyone, especially a child, accidentally drinks Lutonaze nasal spray, contact your doctor or nearest hospital as soon as possible.
Use your nasal spray as soon as you remember, then take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose.
Do not stop using Lutonaze nasal spray without asking your doctor, because this puts the success of the treatment at risk.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Very common (may affect more than 1 in 10 people):
Common (may affect up to 1 in 10 people):
Uncommon (may affect up to 1 in 100 people):
Rare (may affect up to 1 in 1,000 people):
Very rare (may affect up to 1 in 10,000 people):
Seek immediate medical help if you have any of the following symptoms:
Unknown (frequency cannot be estimated from available data):
Systemic side effects (side effects affecting the whole body) may occur when this medicine is used at high doses for a long time. These effects are much less likely to occur if you use a corticosteroid nasal spray than if you take corticosteroids by mouth. These effects may vary in individual patients and between different corticosteroid preparations (see section 2).
Nasal corticosteroids can affect the normal production of hormones in your body, particularly if you use high doses for a long time. In children and adolescents this side effect can cause them to grow more slowly than others.
In rare cases a reduction of the bone density (osteoporosis) was observed if nasal corticosteroids were administered long-term.
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the bottle label and the outer carton after “EXP”. The expiry date refers to the last day of that month.
Do not refrigerate or freeze.
Shelf life after first opening: Dispose of any unused medicine 6 months after you first open the nasal spray.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
The active substances are azelastine hydrochloride and fluticasone propionate
Each gram of suspension contains 1000 micrograms of azelastine hydrochloride and 365 micrograms of fluticasone propionate.
Each actuation (0.14 g) delivers 137 micrograms of azelastine hydrochloride (equivalent to 125 micrograms of azelastine) and 50 micrograms of fluticasone propionate.
The other ingredients are: Disodium edetate, glycerol, microcrystalline cellulose, carmellose sodium, polysorbate 80, benzalkonium chloride, phenethyl alcohol and purified water.
Lutonaze nasal spray is a white, homogenous suspension.
It comes in an amber coloured glass bottle fitted with a spray pump, applicator and a protective cap.
The 30 mL bottle contains 23 g nasal spray, suspension (at least 120 actuations).
Pack size: 1 bottle
Marketing Authorisation Holder
Manufacturer
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This leaflet was last revised in June 2026
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