Patient Leaflet Updated 30-Apr-2026 | Zentiva
Noradrenaline (Norepinephrine) 1 mg/ml Concentrate for Solution for Infusion
Noradrenaline (Norepinephrine) 1 mg/ml Concentrate for Solution for Infusion
Noradrenaline (as noradrenaline tartrate)
Read all of this leaflet carefully before you start using this medicine because it contains important information for you.
The name of this medicinal product is Noradrenaline (Norepinephrine) 1 mg/ml Concentrate for Solution for Infusion but it will be referred to as Noradrenaline (Norepinephrine) Concentrate throughout this leaflet.
1. What Noradrenaline (Norepinephrine) Concentrate is and what it is used for
2. What you need to know before you are given Noradrenaline (Norepinephrine) Concentrate
3. How to use Noradrenaline (Norepinephrine) Concentrate
4. Possible side effects
5. How to store Noradrenaline (Norepinephrine) Concentrate
6. Contents of the pack and other information
Noradrenaline (Norepinephrine) Concentrate for Solution for Infusion is used in an emergency to increase blood pressure to normal levels.
It contains the active ingredient noradrenaline which belongs to a group of medicines called adrenergic and dopaminergic agents.
Do not take Noradrenaline (Norepinephrine) Concentrate:
Tell your doctor if any of the above applies to you before this medicine is used.
Talk to your doctor or pharmacist before taking Noradrenaline (Norepinephrine) Concentrate if you have:
Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines.
A number of medicines are known to increase the toxic effects of noradrenaline, such as:
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Noradrenaline (Norepinephrine) Concentrate may harm the unborn baby. Your doctor will decide if you should be given Noradrenaline (Norepinephrine) Concentrate.
This medicine contains 13.3 mg of sodium (main component of cooking/table salt) in each 4 ml ampoule and 33.3 mg of sodium in 10 ml ampoule. This is equivalent to 0.7% and 1.7% of the recommended maximum daily dietary intake of sodium for an adult, respectively. This medicine may be diluted with sodium-containing solutions. Take into consideration if you are on a low-sodium diet.
Noradrenaline (Norepinephrine) Concentrate will be given to you in hospital by a doctor or nurse. It is first diluted and then infused into a vein.
The recommended dose of Noradrenaline (Norepinephrine) Concentrate will depend on your medical condition. The usual dose is between 0.4 and 0.8 mg per hour. Your doctor will determine the correct dose for you. After the initial dose your doctor will assess your response and adjust the dose accordingly.
It is unlikely that you will receive too much or too little of this medicine, as this medicine will be given to you in hospital.
However, talk to your doctor or nurse if you have any concerns.
Symptoms of overdose are severe high blood pressure, slow heartbeat, violent headache, difficulty breathing due to fluids in the lungs, light sensitivity, pain in the chest, pale colour, intense sweating and vomiting.
Like all medicines, this medicine can cause side effects, although not everybody gets them. Tell your doctor immediately if you experience:
Tell your doctor as soon as possible if you experience:
Your doctor will monitor your blood pressure and blood volume.
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Store below 25° C.
Keep the ampoule in the outer carton in order to protect from light.
Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry date refers to the last day of that month.
Chemical and physical in-use stability has been demonstrated for 48 hours at 22 ± 2° C exposed to daily light cycles and 30° C for diluted concentrate in glucose 5% (w/v), sodium chloride 0.9% (w/v) and sodium chloride 0.45% (w/v) with glucose 5% (w/v). From a microbiological point of view, the product should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2 to 8° C, unless dilution has taken place in controlled and validated aseptic conditions.
The medicine should not be used if the solution contains visible particles/solids.
Do not use this medicine if the solution is brown in colour.
Do not throw away any medicines via wastewater. Ask your pharmacists how to throw away medicines you no longer use. These measures will help protect the environment.
The active substance is noradrenaline (as noradrenaline tartrate).
1 ml of concentrate for solution for infusion contains 2 mg noradrenaline tartrate equivalent to 1 mg noradrenaline base.
Each 4 ml ampoule of concentrate for infusion contains 8 mg noradrenaline tartrate equivalent to 4 mg noradrenaline base.
Each 10 ml ampoule of concentrate for infusion contains 20 mg noradrenaline tartrate equivalent to 10 mg noradrenaline base.
The other ingredients are:
This medicinal product is presented as a concentrate for solution for infusion in a clear glass ampoule, hydrolytic class No. I. The solution is a clear colourless to yellowish concentrate for solution for infusion, free of any visible particles.
It is supplied in packs of 5, 10 or 50 ampoules containing 4 ml and 10 ampoules containing 4 ml.
Not all pack sizes may be marketed.
Marketing Authorisation Holder
Manufacturer
This leaflet was last revised in June 2025.
For information in large print, tape, CD or Braille, telephone 0800 198 5000.
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+44 (0)844 8793 188
https://www.zentiva.co.uk/contact/mi-form
+44 (0)800 090 2408
