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The eMC  

Last Updated 30 Sep 2013

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Travoprost 40micrograms/ml / Timolol 5mg/ml eye drops

Timolol maleate/Travoprost (Tim-ol-ol mal-ee-ate/Trav-oh-prost) is a medicine which is used in ocular hypertension and open-angle glaucoma.

The information in this Medicine Guide for Timolol maleate/travoprost varies according to the condition being treated and the particular preparation used.

Travoprost 40micrograms/ml / Timolol 5mg/ml eye drops

Information specific to Travoprost 40micrograms/ml / Timolol 5mg/ml eye drops when used in Ocular hypertension

Your medicine

Timolol maleate/Travoprost contains two medicinestravoprost and timolol maleate. Timolol maleate/Travoprost is used in conditions such as ocular hypertension or open-angle glaucoma where there is increased pressure inside the eye. It works by reducing the amount of fluid that is produced inside the eye and helps improve drainage of fluid from the eye. This leads to a reduction in pressure inside the eye.

Other information about Timolol maleate/Travoprost:

  • take care when putting Timolol maleate/Travoprost into the eye, as the dropper must not touch any part of the eye or any other surface as this may contaminate the drops remaining in the bottle
  • if you wear contact lenses you should check with your prescriber if you can use this medicine while wearing contact lenses
  • if you are using other eye medicines do not use one immediately after each other. This is to stop the second medicine from washing the first medicine out of the eye. You should find out from your prescriber how long you need to wait before using the second medicine
  • press down on the inner part of the eye when adding the drops to the eye and for few minutes after adding the drops to the eye. This will help to reduce the amount of Timolol maleate/Travoprost that gets into the general circulation of the body after using Timolol maleate/Travoprost in the eye

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should use. It also tells you how often you should use your medicine. This is the dose that you and your prescriber have agreed you should use. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

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When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most from your medicine can also be affected by the times at which you take other medicines.

Specific information on when to use Timolol maleate/Travoprost can be found in the Patient Information Leaflet that comes with this medicine. Alternatively, you can request information about when to take your medicine from your doctor or pharmacist.

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How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine.

Specific information on how to use Timolol maleate/Travoprost can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. Alternatively, you can request information about how to take your medicine from your doctor or pharmacist.

If you are having problems taking this form of Timolol maleate/Travoprost, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other preparations that are easier for you to take.

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Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. You may need a test to assess the effect of taking extra doses. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or NHS Direct on 0845 46 47 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

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Stopping your medicine

Suddenly stopping your medicine may cause your original condition to return. This is why you must speak to your prescriber if you are having any problems using your medicine.

If you are not having any problems taking this medicine then do not stop using it, even if you feel better, unless advised to do so by your prescriber.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or NHS Direct on 0845 46 47.

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Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. It is a good idea to keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

Specific information on how to look after Timolol maleate/Travoprost can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. Alternatively, you can request information about how to look after your medicine from your doctor or pharmacist.

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

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Whether this medicine is suitable for you

Timolol maleate/Travoprost is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for someone who is under the age of 18 years.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to determine whether or not the medicine is suitable and whether it must be prescribed with extra care
  • to check that this medicine is having the desired effect
  • to check that this medicine is not having any undesired effects

Over time it is possible that Timolol maleate/Travoprost can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Timolol maleate/Travoprost has become unsuitable, it is important that the prescriber is contacted immediately.

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Side-effects

A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Very common: More than 1 in 10 people who use Timolol maleate/Travoprost

  • red eye

Common: More than 1 in 100 people who use Timolol maleate/Travoprost

  • blurred vision
  • dry eye
  • eye discomfort
  • eye pain
  • irritation of the eye
  • itching of the eyes
  • other eye or eyesight problems

Uncommon: More than 1 in 1000 people who use Timolol maleate/Travoprost

Rare: More than 1 in 10,000 people who use Timolol maleate/Travoprost

  • abnormal laboratory test results
  • bleeding from the eye
  • bronchospasm - this may be fatal in asthmatics
  • cough
  • crusting of the eyelid margin
  • difficulty speaking
  • feeling nervous
  • hair loss
  • heart problems
  • irregular heart rate
  • nasal discomfort
  • painful extremities
  • skin colour changes
  • thirst
  • throat pain or irritation
  • urine colour changes

The frequency of these side-effects is unknown

These side-effects have been reported when people have taken travoprost which is one of the ingredients in Timolol maleate/Travoprost. The frequency of these side-effects in people who use Timolol maleate/Travoprost is not known

  • eye colour changes which may be permanent
  • skin exfoliation

These side-effects have been reported when people have taken timolol which is one of the ingredients in Timolol maleate/Travoprost. The frequency of these side-effects in people who use Timolol maleate/Travoprost is not known

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call NHS Direct on 0845 46 47.

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Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Timolol maleate/Travoprost:

The following types of medicine may interact with Timolol maleate/Travoprost:

If you are taking Timolol maleate/Travoprost and one of the above medicines or types of medicines, make sure your prescriber knows about it.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Timolol maleate/Travoprost.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Timolol maleate/Travoprost:

  • after putting Timolol maleate/Travoprost into your eye you may have blurred vision for a short time

You must not drive or operate machinery unless your vision has returned to normal after using Timolol maleate/Travoprost.

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Diet

Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Timolol maleate/Travoprost:

  • there are no specific foods that you must exclude from your diet when using Timolol maleate/Travoprost
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Alcohol

Alcohol can interact with certain medicines.

In the case of Timolol maleate/Travoprost:

  • there are no known interactions between alcohol and Timolol maleate/Travoprost
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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Timolol maleate/Travoprost:

  • you should only use this medicine during pregnancy if your doctor thinks that you need it
  • if you use this medicine during your pregnancy, your baby may need to have some monitoring after birth
  • if you could become pregnant, you must use effective contraception or abstain from penetrative sex. You must contact your prescriber if you become pregnant, or think you have become pregnant, while using Timolol maleate/Travoprost

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Timolol maleate/Travoprost, then you should discuss whether there is an alternative medicine that you could take during pregnancy.

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Breast-feeding

Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Timolol maleate/Travoprost:

  • using this medicine is not recommended while breast-feeding

Before you have your baby you should discuss breast-feeding with your doctor or midwife. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed. You should not stop this medicine without taking advice from your doctor.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's appearance and to make it easier to use. Some may be used to prolong the life of the medicine.

This medicine contains timolol maleate and travoprost.

We are unable to list all of the ingredients for your medicine here. For a full list, you should refer to the patient information leaflet that comes with this medicine. You should check that you are able to take the ingredients of your medicine, especially if you have any allergies. You should also check whether any of these ingredients are known to have side-effects.

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Timolol maleate/Travoprost before, do not take Timolol maleate/Travoprost. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Timolol maleate/Travoprost, Version 8, last updated 30 Sep 2013