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The eMC  

Last Updated 17 Mar 2014

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Tacrolimus 0.1% ointment

Tacrolimus monohydrate (Tak-roh-lim-us mon-oh-hi-drate) is a medicine which is used in eczema, preventing rejection of a heart transplant, preventing rejection of a kidney transplant, preventing rejection of a liver transplant and treating transplant rejection that has not responded to other treatments.

The information in this Medicine Guide for Tacrolimus monohydrate varies according to the condition being treated and the particular preparation used.

There are 2 preparations of Tacrolimus monohydrate available. If Tacrolimus 0.1% ointment is not the preparation you are looking for, please select from the drop down list below.

Select your preparation (type) of Tacrolimus monohydrate

Tacrolimus 0.1% ointment

Information specific to Tacrolimus 0.1% ointment when used in Inflammatory skin conditions

Your medicine

Tacrolimus monohydrate helps to suppress overactivity of the immune system and reduce inflammation. Tacrolimus monohydrate is used to treat eczema.

While you are using Tacrolimus monohydrate, it is important to protect the skin from the effects of UV light. You should try reducing the time you are exposed to direct sunlight. Areas which have been treated with Tacrolimus monohydrate should not be exposed to the sun and should be covered with appropriate clothing or a high protection sun screen. You should also avoid using tanning beds or lamps while you are using Tacrolimus monohydrate.

If your symptoms start to return it is best to start using Tacrolimus monohydrate immediately. This will help to stop the symptoms from becoming worse. When your symptoms have resolved again you can stop using Tacrolimus monohydrate.

Other information about Tacrolimus monohydrate:

  • it is best to start using Tacrolimus monohydrate as soon as you get signs and symptoms of eczema
  • if your symptoms get worse or do not improve within two weeks of starting treatment with Tacrolimus monohydrate you should contact your prescriber
  • you should use Tacrolimus monohydrate in affected area once a day twice weekly and wait for 2-3 days before you can have further treatment with Tacrolimus monohydrate
  • if you are responding to up to six weeks of treatment, you are suitable for maintenance treatment
  • your prescriber will review the need for you to continue treatment with Tacrolimus monohydrate once a year

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should use. It also tells you how often you should use your medicine. This is the dose that you and your prescriber have agreed you should use. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

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When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most from your medicine can also be affected by the times at which you take other medicines.

Specific information on when to use Tacrolimus monohydrate can be found in the Patient Information Leaflet that comes with this medicine. Alternatively, you can request information about when to take your medicine from your doctor or pharmacist.

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How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine.

Specific information on how to use Tacrolimus monohydrate can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. Alternatively, you can request information about how to take your medicine from your doctor or pharmacist.

If you are having problems taking this form of Tacrolimus monohydrate, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other preparations that are easier for you to take.

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Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or NHS Direct on 0845 46 47 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

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Stopping your medicine

If you are not having any problems with this medicine, do not stop using it unless you have completed the course or you are advised to stop using it by your prescriber.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or NHS Direct on 0845 46 47.

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Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. It is a good idea to keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

Specific information on how to look after Tacrolimus monohydrate can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. Alternatively, you can request information about how to look after your medicine from your doctor or pharmacist.

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

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Whether this medicine is suitable for you

Tacrolimus monohydrate is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for someone who is under the age of 16 years.

Over time it is possible that Tacrolimus monohydrate can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Tacrolimus monohydrate has become unsuitable, it is important that the prescriber is contacted immediately.

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Side-effects

A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Very common: More than 1 in 10 people who use Tacrolimus monohydrate

Common: More than 1 in 100 people who use Tacrolimus monohydrate

Uncommon: More than 1 in 1000 people who use Tacrolimus monohydrate

The frequency of these side-effects is unknown

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call NHS Direct on 0845 46 47.

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Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Tacrolimus monohydrate:

The following types of medicine may interact with Tacrolimus monohydrate:

If you are taking Tacrolimus monohydrate and one of the above medicines or types of medicines, make sure your prescriber knows about it.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Tacrolimus monohydrate.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Tacrolimus monohydrate:

  • this medicine is unlikely to affect driving ability or the ability to operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

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Diet

Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Tacrolimus monohydrate:

  • there are no specific foods that you must exclude from your diet when using Tacrolimus monohydrate
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Alcohol

Alcohol can interact with certain medicines.

In the case of Tacrolimus monohydrate:

  • you are more likely to have reactions such as skin rashes or flushing of the face if you use Tacrolimus monohydrate and drink alcohol

You need to consider whether drinking alcohol is a suitable thing for you to do while you are taking Tacrolimus monohydrate. It is a good idea to find out how the medicine will affect you before making your decision. If you are in any doubt, or if you want more advice, discuss this with your prescriber.

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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Tacrolimus monohydrate:

  • do not use this medicine during pregnancy

You should discuss your personal circumstances with your doctor if you are pregnant or want to become pregnant. This is so that together you can make a decision about what treatment you may need during your pregnancy.

You should discuss whether there are any other medicines which you could take during pregnancy which would treat your condition.

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Breast-feeding

Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Tacrolimus monohydrate:

  • breast-feeding is not recommended while using this medicine

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. You should only breast-feed your baby while taking this medicine on the advice of your doctor or midwife.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's appearance and to make it easier to use. Some may be used to prolong the life of the medicine.

This medicine contains tacrolimus monohydrate.

We are unable to list all of the ingredients for your medicine here. For a full list, you should refer to the patient information leaflet that comes with this medicine. You should check that you are able to take the ingredients of your medicine, especially if you have any allergies. You should also check whether any of these ingredients are known to have side-effects.

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Tacrolimus monohydrate before, do not take Tacrolimus monohydrate. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Tacrolimus monohydrate, Version 22, last updated 17 Mar 2014