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The eMC  

Last Updated 03 Apr 2014

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Questran 4g oral powder sachets

Questran (Kwest-tran) is a medicine which is used in hypercholesterolaemia, relieving diarrhoea associated with radiotherapy, ileal resection, Crohn's disease, vagotomy or diabetic vagal neuropathy and relieving itchiness linked to liver problems. Questran contains colestyramine anhydrous. It is supplied by Bristol-Myers Squibb Holdings Limited.

The information in this Medicine Guide for Questran varies according to the condition being treated and the particular preparation used.

There are 2 preparations of Questran available. If Questran 4g oral powder sachets is not the preparation you are looking for, please select from the drop down list below.

Select your preparation (type) of Questran

Questran 4g oral powder sachets

Information specific to Questran 4g oral powder sachets when used in relieving diarrhoea associated with radiotherapy, ileal resection, Crohn's disease, vagotomy or diabetic vagal neuropathy

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Your medicine

Questran reduces the amount of cholesterol absorbed into the body. It can also help to relieve certain types of diarrhoea and in people with liver problems it can help to relieve itchiness.

Other information about Questran:

  • people starting treatment with this form of this medicine will normally be prescribed a low dose. The dose will then be gradually increased. This is in order to reduce the chance of side-effects

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

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When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most from your medicine can also be affected by what you eat, when you eat and the times at which you take other medicines. Make sure you follow any specific instructions given to you by your prescriber or that are in the Patient Information Leaflet that comes with this medicine.

In the case of Questran:

  • take other medicines at least one hour before or four to six hours after you take Questran
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How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine. Make sure you follow any specific instructions given to you by your prescriber or that are in the Patient Information Leaflet that comes with this medicine.

In the case of Questran:

  • do not take the powder in the original dry form. Add the dose to either water, fruit juice, thin soups, skimmed milk or pulpy fruits that have a high water content such as apple sauce. Mix well to a uniform consistency before you take it

If you are having problems taking this medicine, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other medicines that are easier for you to take.

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Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. You may need a test to assess the effect of taking extra doses. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or call 111 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

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Stopping your medicine

Suddenly stopping your medicine may cause your original condition to return. This is why you must speak to your prescriber if you are having any problems taking your medicine.

If you are not having any problems taking this medicine then do not stop taking it, even if you feel better, unless advised to do so by your prescriber.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or call 111.

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Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. You should keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

In the case of Questran:

  • do not store in temperatures above 30°C

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

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Whether this medicine is suitable for you

Questran is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for a child who is under six years of age.

Over time it is possible that Questran can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Questran has become unsuitable, it is important that the prescriber is contacted immediately.

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Side-effects

A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Very common: More than 1 in 10 people who take Questran:

  • constipation - this may occur if Questran is taken at a high dose. Seek medical advice if you develop constipation

Uncommon: More than 1 in 1000 people who take Questran:

Rare: More than 1 in 10,000 people who take Questran:

The frequency of these side-effects is unknown:

  • abnormal laboratory test results

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call 111.

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Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Questran:

The following types of medicine may interact with Questran:

If you are taking Questran and one of the above medicines or types of medicines, make sure your prescriber knows about it.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins.

Make sure you tell your prescriber the names of all the complementary preparations and vitamins that you are taking or are planning to take.

Your prescriber can then decide whether it is appropriate for you to take combinations that are known to interact.

In the case of Questran:

If you have been prescribed Questran you should only take something on the above list on the specific advice of your prescriber or pharmacist.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Questran:

  • this medicine could affect your ability to drive or operate machinery. However, its impact on someone driving or operating machinery may not be relevant

Like all medicines Questran can cause side effects. You should see how this medicine affects you and then judge if you are safe to drive or operate machinery. If you are in any doubt, talk to your prescriber.

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Diet

Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Questran:

Your doctor may recommend that you take vitamin A, D and K or folic acid supplements while you are taking Questran.

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Alcohol

Alcohol can interact with certain medicines.

In the case of Questran:

  • there are no known interactions between alcohol and Questran
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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

Careful consideration needs to be given to the risks and the benefits of using this medicine during pregnancy.

You need to discuss your specific circumstances with your doctor to make a decision about whether you are going to take this medicine during pregnancy. You should only take this medicine during pregnancy if your doctor thinks you need to take it. If the decision is that you should not have Questran, then you should discuss whether there is an alternative medicine that you could take during pregnancy.

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Breast-feeding

Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. You should only breast-feed your baby while taking this medicine on the advice of your doctor or midwife.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's taste and appearance and to make it easier to take. Some may be used to prolong the life of the medicine.

You should check that you are able to take the ingredients in your medicine, especially if you have any allergies.

Questran contains:

  • acacia
  • alginate
  • citric acid anhydrous
  • orange juice flavour
  • polysorbate 80
  • propylene glycol
  • sucrose

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Questran before, do not take Questran. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Questran, Version 7, last updated 03 Apr 2014