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The eMC  

Last Updated 28 Apr 2015

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Procoralan 5mg tablets

Procoralan (pro-cor-a-lan) is a medicine which is used in angina and heart failure. Procoralan contains ivabradine hydrochloride. It is supplied by Servier Laboratories Limited.

The information in this Medicine Guide for Procoralan varies according to the condition being treated and the particular preparation used.

There are 2 preparations of Procoralan available. If Procoralan 5mg tablets is not the preparation you are looking for, please select from the drop down list below.

Select your preparation (type) of Procoralan

Procoralan 5mg tablets

Information specific to Procoralan 5mg tablets when used in angina

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Your medicine

Procoralan is used to treat angina.

Angina pain is caused by the heart being short of oxygen. The heart needs more oxygen in response to exercise or exertion which raises the heart rate. In people who have restricted blood flow to the heart, the oxygen needs of the heart cannot be met during exercise or exertion and this causes angina pain.

Procoralan makes the heart beat more slowly and limits the increase in heart rate that can occur in response to exertion. This helps prevent angina pain from occurring.

Other information about Procoralan:

  • your doctor may start you on a low dose of this medicine and then increase the dose depending on how you respond to treatment
  • if your symptoms get worse or do not improve within three months of starting treatment with Procoralan you should contact your prescriber

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

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When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most from your medicine can also be affected by what you eat, when you eat and the times at which you take other medicines.

In the case of Procoralan:

  • Procoralan is taken twice a day, once in the morning and once in the evening
  • it is best to take Procoralan with a meal
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How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine. Make sure you follow any specific instructions given to you by your prescriber or that are in the Patient Information Leaflet that comes with this medicine.

In the case of Procoralan:

  • you can break this form of medicine in half. There is a break line to help you break the medicine into two pieces

If you are having problems taking this form of Procoralan, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other preparations that are easier for you to take.

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Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. You may need a test to assess the effect of taking extra doses. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or call 111 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

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Stopping your medicine

Suddenly stopping your medicine may cause your original condition to return. This is why you must speak to your prescriber if you are having any problems taking your medicine.

If you are not having any problems taking this medicine then do not stop taking it, even if you feel better, unless advised to do so by your prescriber.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or call 111.

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Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. You should keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

In the case of Procoralan:

  • there are no special instructions on how to look after your medicine

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

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Whether this medicine is suitable for you

Procoralan is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to check that this medicine is not having any undesired effects
  • to determine whether or not the medicine is suitable and whether it must be prescribed with extra care
  • to confirm that this is the right dose
  • to check that this medicine is having the desired effect

Over time it is possible that Procoralan can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Procoralan has become unsuitable, it is important that the prescriber is contacted immediately.

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A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Very common: More than 1 in 10 people who take Procoralan:

  • eye or eyesight problems - you must seek medical advice if you have any visual disturbances

Common: More than 1 in 100 people who take Procoralan:

  • blood pressure changes
  • blurred vision
  • ECG changes
  • headaches
  • heart or circulation problems
  • slower heart rate which may cause dizziness, tiredness, weakness, lowered blood pressure, general feeling of being unwell, fainting or brief loss of consciousness. You should seek medical advice if you get any of these symptoms or if these symptoms last for a long time
  • worsening of heart problems

Uncommon: More than 1 in 1000 people who take Procoralan:

Rare: More than 1 in 10,000 people who take Procoralan:

The frequency of these side-effects is unknown:

  • irregular heart rate
  • worsening of the problem that Procoralan is being used to treat

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call 111.

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Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Procoralan:

The following types of medicine may interact with Procoralan:

If you are taking Procoralan and one of the above medicines or types of medicines, make sure your prescriber knows about it.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins.

Make sure you tell your prescriber the names of all the complementary preparations and vitamins that you are taking or are planning to take.

Your prescriber can then decide whether it is appropriate for you to take combinations that are known to interact.

In the case of Procoralan:

If you have been prescribed Procoralan you should only take something on the above list on the specific advice of your prescriber or pharmacist.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Procoralan:

  • this medicine could affect your ability to drive or operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

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Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Procoralan:

  • this medicine interacts with grapefruit juice. Grapefruit juice increases the level of Procoralan in your blood. You should restrict the amount of grapefruit juice you have in your diet

For more advice speak to your prescriber, dietitian or pharmacist.

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Alcohol can interact with certain medicines.

In the case of Procoralan:

  • there are no known interactions between alcohol and Procoralan
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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Procoralan:

  • do not take this medicine during pregnancy
  • if you could become pregnant, you must use effective contraception or abstain from penetrative sex

This medicine is not suitable during pregnancy. It is very important that you seek urgent medical advice if you become pregnant or think you have become pregnant while taking this medicine.

If you are planning to become pregnant, you should discuss your personal circumstances with your doctor so that together you can make a decision about what treatment you may need during your pregnancy.

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Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

Women who are taking Procoralan must not breast-feed. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could have. You should not stop this medicine without taking advice from your doctor.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's taste and appearance and to make it easier to take. Some may be used to prolong the life of the medicine.

You should check that you are able to take the ingredients in your medicine, especially if you have any allergies.

Procoralan contains:

  • glycerol (E422)
  • hypromellose (E464)
  • lactose monohydrate
  • macrogol 6000
  • magnesium stearate (E470b)
  • maize starch
  • maltodextrin
  • red iron oxide (E172)
  • silica, anhydrous collodial (E551)
  • titanium dioxide (E171)
  • yellow iron oxide (E172)

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Procoralan before, do not take Procoralan. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Procoralan, Version 13, last updated 28 Apr 2015