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The eMC  

Last Updated 04 Sep 2014

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Glipizide 5mg tablets

Glipizide (Glip-iz-ide) is a medicine which is used in diabetes mellitus.

The information in this Medicine Guide for Glipizide varies according to the condition being treated and the particular preparation used.

Glipizide 5mg tablets

Information specific to Glipizide 5mg tablets when used in diabetes mellitus

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Your medicine

Diabetes leads to problems controlling blood sugar levels. Glipizide increases the amount of insulin produced by the body. Insulin is a hormone that helps the body to use the sugar in the blood properly and it helps to prevent the blood sugar level from becoming too high.

In diabetes, the body may not be able to produce enough insulin or the insulin that it produces may not have the full effect. In some instances, the body may not be able to produce any insulin at all. These can all lead to problems controlling the blood sugar level.

It is very important that your blood sugar level is well controlled. Blood sugar levels which are too high or too low can be dangerous. Your prescriber or a member of your diabetes team will be able to give you information on how to recognise the warning signs of high and low blood sugar levels. They will also be able to tell you what to do if either of these occurs.

Warning signs can vary from person to person. If the usual warning signs of poorly controlled blood sugar levels change or disappear, you should contact your prescriber or a member of your diabetes team.

The amount of Glipizide you need to control your blood sugar levels will be worked out by your prescriber or your diabetes team. They may also advise you to measure your blood or urine sugar regularly – they will show you how to do this. If you are having problems controlling or measuring your blood or urine sugar, you should contact your prescriber or a member of your diabetes team.

Other information about Glipizide:

  • your prescriber may vary the dose of your medicine to find what is best for controlling your blood sugar level, especially if your circumstances change. These circumstances may include changes to your diet or alcohol intake; changes to your health during periods of illness or emotional stress; changes to the amount of physical activity that you are doing or changes to the timing of your meals
  • your prescriber may vary the dose of your medicine to find what is best for you

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

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When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most benefit from your medicine can also be affected by what you eat, when you eat and the times at which you take other medicines.

Specific information on when to take Glipizide can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. You can also ask your doctor or pharmacist for information about when to take your medicine.

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How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine.

Specific information on how to take Glipizide can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. Alternatively, you can request information about how to take your medicine from your doctor or pharmacist.

If you are having problems taking this form of Glipizide, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other preparations that are easier for you to take.

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Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. You may need a test to assess the effect of taking extra doses. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or call 111 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

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Stopping your medicine

Suddenly stopping your medicine may cause your original condition to return. This is why you must speak to your prescriber if you are having any problems taking your medicine.

If you are not having any problems taking this medicine then do not stop taking it, even if you feel better, unless advised to do so by your prescriber.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or call 111.

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Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. It is a good idea to keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

Specific information on how to look after Glipizide can be found in the Patient Information Leaflet that comes with this medicine or on the medicine label. Alternatively, you can request information about how to look after your medicine from your doctor or pharmacist.

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

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Whether this medicine is suitable for you

Glipizide is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

Furthermore, the prescriber may only prescribe this medicine with special care or may not prescribe it at all for a child or for someone who is in a coma.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to check that this medicine is having the desired effect
  • to check that this medicine is not having any undesired effects

Over time it is possible that Glipizide can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Glipizide has become unsuitable, it is important that the prescriber is contacted immediately.

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Side-effects

A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Common: More than 1 in 100 people who take Glipizide:

  • decreased blood sugar levels - very low blood sugar levels may lead to confusion, feeling dizzy, sleepiness, tremors, headaches, blurred vision, double vision, eye or eyesight problems, or general feeling of being unwell
  • diarrhoea
  • nausea
  • stomach pain

Uncommon: More than 1 in 1000 people who take Glipizide:

  • eczema - if eczema persist you should seek medical advice
  • jaundice - seek medical advice if you have jaundice
  • vomiting

The frequency of these side-effects is unknown:

  • abnormal laboratory test results
  • blood and bone marrow problems
  • constipation
  • liver problems
  • metabolic problems
  • photosensitivity skin reaction
  • porphyria or porphyria-like reaction
  • skin problems such as certain types of dermatitis, redness of the skin, skin rash or rashes, maculopapular rash, urticaria or itching - if any of these skin problems persist you should seek medical advice

The following side effects have been reported in people who have had medicines similar to Glipizide. The frequency of these side-effects in people who take Glipizide is not known:

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call 111.

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Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Glipizide:

The following types of medicine may interact with Glipizide:

If you are taking Glipizide and one of the above medicines or types of medicines, make sure your prescriber knows about it.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Glipizide.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Glipizide:

  • your ability to drive or operate machinery may be affected if your blood sugar levels are low

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

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Diet

Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Glipizide:

  • Glipizide is not known to interact with food. You should continue on the diet advised by your dietician or prescriber

For more advice speak to your prescriber, nutritionist or pharmacist.

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Alcohol

Alcohol can interact with certain medicines.

In the case of Glipizide:

You should seek advice from your prescriber as to whether you may drink alcohol while taking this medicine.

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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Glipizide:

  • do not take this medicine during pregnancy

People with diabetes may start to have insulin instead of Glipizide to control their blood sugar during pregnancy. If you are taking Glipizide and are planning to become pregnant, become pregnant or think that you are pregnant, talk to a member of your diabetes team. For more information on managing your diet and your diabetes during your pregnancy, talk to your prescriber or a member of your diabetes or antenatal team.

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Breast-feeding

Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Glipizide:

  • women who are breast-feeding must not take this medicine

Before you have your baby you should discuss breast-feeding with your doctor or midwife. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed. You should not stop this medicine without taking advice from your doctor.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's taste and appearance and to make it easier to take. Some may be used to prolong the life of the medicine.

This medicine contains glipizide.

We are unable to list all of the ingredients for your medicine here. For a full list, you should refer to the patient information leaflet that comes with this medicine. You should check that you are able to take the ingredients of your medicine, especially if you have any allergies. You should also check whether any of these ingredients are known to have side-effects.

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Glipizide before, do not take Glipizide. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Glipizide, Version 8, last updated 04 Sep 2014