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The eMC  

Last Updated 27 Jul 2015

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Brilique 90mg tablets

Brilique (Bril-eek) is a medicine which is used in prevention of thrombotic events. Brilique contains ticagrelor. It is supplied by AstraZeneca UK Limited.

The information in this Medicine Guide for Brilique varies according to the condition being treated and the particular preparation used.

Brilique 90mg tablets

Information specific to Brilique 90mg tablets when used in prevention of thrombotic events

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Your medicine

Brilique prevents platelets in the blood from clumping together and forming a clot. In some people a clot can lead to the blood vessel becoming blocked. A blocked blood vessel may result in problems such as a heart attack or a stroke. Brilique can be used to help prevent these sorts of problems in people who are at risk of having them. This includes people who have already had a heart attack or people who have unstable angina. Brilique is usually taken in combination with aspirin.

Other information about Brilique:

  • your prescriber will review your treatment with Brilique after one year
  • if you are about to have surgery or dental treatment you may need to stop taking Brilique before you can have your treatment. For more information speak to a member of your medical team

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

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When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most from your medicine can also be affected by what you eat, when you eat and the times at which you take other medicines.

In the case of Brilique:

  • if you miss a dose of Brilique then just take your next dose as usual at the scheduled time. Do not take an extra dose to make up for the missed one
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How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine.

In the case of Brilique:

  • this medicine can be taken with or without food
  • if you have problems swallowing

    • crushed the tablet to a fine powder and mixed in a half glass of water and drink it immediately
    • to make sure there is no medicine left, the glass should be rinsed with a further half glass of water and drink the contents

If you are having problems taking this form of Brilique, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other preparations that are easier for you to take.

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Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. You may need a test to assess the effect of taking extra doses. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or call 111 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

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Stopping your medicine

If you are having any problems taking your medicine you must speak to your prescriber. If you are not having any problems taking this medicine then do not stop taking it, even if you feel better, unless advised to do so by your prescriber.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or call 111.

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Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. You should keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

In the case of Brilique:

  • there are no special instructions on how to look after your medicine

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

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Whether this medicine is suitable for you

Brilique is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for someone who is under the age of 18 years.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to check that this medicine is not having any undesired effects

Over time it is possible that Brilique can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Brilique has become unsuitable, it is important that the prescriber is contacted immediately.

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A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Common: More than 1 in 100 people who take Brilique:

  • bleeding from injection or catheter sites
  • bleeding in the stomach
  • bleeding under the skin or from the skin
  • breathing difficulties - seek medical advice if you develop breathing difficulties for the first time or if your existing breathing problems worsen
  • bruising
  • collection of blood under the skin
  • easy bruising of the skin
  • melaena
  • nose bleed
  • petechiae
  • rectal bleeding

Uncommon: More than 1 in 1000 people who take Brilique:

Rare: More than 1 in 10,000 people who take Brilique:

  • abnormal laboratory test results
  • bleeding from the ears, wounds or sites of injury
  • bleeding in the abdomen or joints
  • confusion
  • constipation
  • paraesthesiae
  • vertigo

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call 111.

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Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Brilique:

The following types of medicine may interact with Brilique:

If you are taking Brilique and one of the above medicines or types of medicines, make sure your prescriber knows about it.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Brilique.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Brilique:

  • this medicine could affect your ability to drive or operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

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Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Brilique:

  • this medicine interacts with grapefruit juice. Grapefruit juice increases the level of Brilique in your blood

If your diet includes any of the above, speak to your prescriber or pharmacist for further advice.

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Alcohol can interact with certain medicines.

In the case of Brilique:

  • there are no known interactions between alcohol and Brilique
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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Brilique:

  • if you could become pregnant, you must use effective contraception or abstain from penetrative sex
  • the use of this medicine during pregnancy is not recommended

You should discuss your personal circumstances with your doctor if you are pregnant or want to become pregnant. This is so that together you can make a decision about what treatment you may need during your pregnancy.

You should discuss whether there are any other medicines which you could take during pregnancy which would treat your condition.

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Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

Women who are taking Brilique must not breast-feed. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could have. You should not stop this medicine without taking advice from your doctor.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's taste and appearance and to make it easier to take. Some may be used to prolong the life of the medicine.

You should check that you are able to take the ingredients in your medicine, especially if you have any allergies.

Brilique contains:

  • dibasic calcium phosphate
  • hydroxypropylcellulose E463
  • hypromellose (E464)
  • magnesium stearate (E470b)
  • mannitol (E421)
  • polyethylene glycol 400
  • sodium starch glycollate
  • talc
  • titanium dioxide (E171)
  • yellow ferric oxide (E172)

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Brilique before, do not take Brilique. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Brilique, Version 7, last updated 27 Jul 2015