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The eMC  

Last Updated 23 Dec 2014

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Votrient 200mg tablets

Votrient (Vot-ree-ent) is a medicine which is used in renal cell carcinoma and treatment of soft tissue sarcomas. Votrient contains pazopanib hydrochloride. It is supplied by GlaxoSmithKline UK.

The information in this Medicine Guide for Votrient varies according to the condition being treated and the particular preparation used.

There are 2 preparations of Votrient available. If Votrient 200mg tablets is not the preparation you are looking for, please select from the drop down list below.

Select your preparation (type) of Votrient

Votrient 200mg tablets

Information specific to Votrient 200mg tablets when used in renal cell carcinoma

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Your medicine

Votrient belongs to a class of medicines called protein kinase inhibitors. It is used to treat advanced cancers of the kidney or certain forms of soft tissue sarcoma that affects the supportive tissues of the body. Votrient works by preventing the actions of proteins that are involved in the growth and spread of cancer cells.

Your medical team will discuss with you the options for treating your cancer. They will take into account factors such as the type of cancer, where it is, which stage it is at and whether you have had treatment before. The results of blood tests and other investigations will also be considered.

How well you feel and how you are likely to cope with treatment is also important.

Votrient also affects healthy cells and may cause adverse effects.

Other information about Votrient:

  • if you are about to have surgery you may need to stop taking Votrient before you can have your operation. For more information speak to a member of your medical team
  • people starting treatment with this form of this medicine will normally be prescribed a low dose. The dose will then be gradually increased. This is in order to reduce the chance of side-effects

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

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When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most from your medicine can also be affected by what you eat, when you eat and the times at which you take other medicines. Make sure you follow any specific instructions given to you by your prescriber or that are in the Patient Information Leaflet that comes with this medicine.

In the case of Votrient:

  • this medicine should not be taken with food. Take it one hour before or two hours after a meal
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How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine. Make sure you follow any specific instructions given to you by your prescriber or that are in the Patient Information Leaflet that comes with this medicine.

In the case of Votrient:

  • swallow whole with a glass of water
  • take your medicine in its original form. You must not break, chew or crush it

If you are having problems taking this medicine, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other medicines that are easier for you to take.

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Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. You may need a test to assess the effect of taking extra doses. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or call 111 for advice.

Make sure you take all of your medicine containers with you if you are advised to go to hospital.

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Stopping your medicine

The person in charge of your care will make the decision about when you should stop this medicine. If you experience any problems while taking this medicine, talk to someone who is involved in your medical care.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or call 111.

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Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. You should keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

In the case of Votrient:

  • there are no special instructions on how to look after your medicine

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

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Whether this medicine is suitable for you

Votrient is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for someone who is under the age of 18 years.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to determine whether or not the medicine is suitable and whether it must be prescribed with extra care
  • to check that this medicine is not having any undesired effects
  • to confirm that this is the right dose

Over time it is possible that Votrient can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Votrient has become unsuitable, it is important that the prescriber is contacted immediately.

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A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

Very common: More than 1 in 10 people who take Votrient:

Common: More than 1 in 100 people who take Votrient:

Uncommon: More than 1 in 1000 people who take Votrient:

  • bleeding problems such as bleeding from the brain, mouth, oesophagus, lungs, abdominal cavity, urinary tract, vagina, haemorrhoids, rectum or anus - some of these bleeding problems may be fatal
  • blood in stools
  • cerebrovascular problems - some of these cerebrovascular problems may be fatal
  • chills
  • ECG changes
  • eye or eyesight problems
  • eyelash colour changes
  • frequent bowel movements
  • gastrointestinal problems including bleeding, perforation or fistula - some of these gastrointestinal problems may be fatal
  • heart attack - this may be fatal
  • heart problems
  • heavy or irregular menstrual periods
  • hypertensive crisis
  • hypoaesthesia
  • infections - some infections may be fatal
  • inflammation of the lining of the abdominal cavity
  • itchy rash
  • jaundice
  • lung problems
  • melaena
  • mucous membrane problems
  • muscle, bone or joint pain
  • nail problems
  • pancreatitis
  • photosensitivity skin reaction
  • redness of the soles of the foot
  • runny nose
  • skin exfoliation
  • skin problems
  • sleepiness
  • slower heart rate
  • stroke - this may be fatal
  • vomiting blood

Rare: More than 1 in 10,000 people who take Votrient:

  • brain or central nervous system problems - some of these may be fatal. Seek medical advice if you develop headache, seizure, lethargy, confusion, blindness, eye or eyesight problems or neurological problems

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call 111.

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Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Votrient:

The following types of medicine may interact with Votrient:

If you are taking Votrient and one of the above medicines or types of medicines, make sure your prescriber knows about it.

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Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Votrient.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Votrient:

  • this medicine could affect your ability to drive or operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

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Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Votrient:

  • this medicine interacts with grapefruit juice. Grapefruit juice increases the level of Votrient in your blood

If your diet includes any of the above, speak to your prescriber or pharmacist for further advice.

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Alcohol can interact with certain medicines.

In the case of Votrient:

  • there are no known interactions between alcohol and Votrient
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Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Votrient:

  • you should only take this medicine during pregnancy if your doctor thinks that you need it
  • this medicine may harm your baby if taken during pregnancy
  • Votrient is a medicine which has implications for pregnancy and while you are taking it you must not become pregnant. If you could become pregnant, you must use effective contraception or abstain from penetrative sex. You must contact your prescriber if you become pregnant, or think you have become pregnant, while taking Votrient

You should discuss your personal circumstances with your doctor if you are pregnant or want to become pregnant. This is so that together you can make a decision about what treatment you may need during your pregnancy.

You should discuss whether there are any other medicines which you could take during pregnancy which would treat your condition.

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Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Votrient:

  • women who are taking Votrient should not breast-feed

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed. You should not stop this medicine without taking advice from your doctor.

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Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's taste and appearance and to make it easier to take. Some may be used to prolong the life of the medicine.

You should check that you are able to take the ingredients in your medicine, especially if you have any allergies.

Votrient contains:

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Votrient before, do not take Votrient. Talk to your prescriber, pharmacist or nurse as soon as possible.

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Votrient, Version 14, last updated 23 Dec 2014