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Sinemet CR and Half Sinemet CR

Last Updated on eMC 02-Oct-2015 View changes  | Merck Sharp & Dohme Limited Contact details

1. Name of the medicinal product

SINEMET® CR 50 mg/200 mg Prolonged-Release Tablets

HALF SINEMET® CR 25 mg/100 mg Prolonged-Release Tablets

2. Qualitative and quantitative composition

Each tablet of 'Sinemet CR' contains carbidopa (equivalent to 50 mg of anhydrous carbidopa) and 200 mg levodopa.

Each tablet of 'Half Sinemet CR' contains carbidopa (equivalent to 25 mg of anhydrous carbidopa) and 100 mg levodopa.

3. Pharmaceutical form

Modified-release tablets.

'Sinemet CR': peach-coloured, oval shaped, biconvex tablets, one side deep-scored and the other marked '521'.

'Half Sinemet CR': pink-coloured, oval-shaped, biconvex tablets, plain one side and the other marked '601'.

4. Clinical particulars
4.1 Therapeutic indications

Antiparkinson agent.

Idiopathic Parkinson's disease, in particular to reduce off-period in patients who previously have been treated with levodopa/decarboxylase inhibitors, or with levodopa alone and who have experienced motor fluctuations. The experience is limited with 'Sinemet CR' and 'Half Sinemet CR' in patients who have not been treated with levodopa before.

4.2 Posology and method of administration

'Sinemet CR' and 'Half Sinemet CR' tablets contain a 1:4 ratio of carbidopa to levodopa ('Sinemet CR': carbidopa 50 mg/levodopa 200 mg, 'Half Sinemet CR' 25 mg/100 mg per tablet). The daily dosage of 'Sinemet CR' must be determined by careful titration. Patients should be monitored closely during the dose adjustment period, particularly with regard to appearance or worsening of nausea or abnormal involuntary movements, including dyskinesias, chorea and dystonia.

Route of administration: oral

'Sinemet CR' and 'Half Sinemet CR' may only be administered as whole tablets. So that the controlled release properties of the product can be maintained, tablets should not be chewed, crushed, or halved.

Standard antiparkinson drugs, other than levodopa alone, may be continued while 'Sinemet CR' or 'Half Sinemet CR' are being administered, although their dosage may have to be adjusted. Since carbidopa prevents the reversal of levodopa effects caused by pyridoxine, 'Sinemet CR' or 'Half Sinemet CR' can be given to patients receiving supplemental pyridoxine (vitamin B6).

Initial Dose

Patients currently treated with conventional levodopa/decarboxylase inhibitor combinations

Dosage with 'Sinemet CR' should be substituted initially at an amount that provides no more than approximately 10% more levodopa per day when higher dosages are given (more than 900 mg per day). The dosing interval between doses should be prolonged by 30 to 50% at intervals ranging from 4 to 12 hours. It is recommended to give the smaller dose, if divided doses are not equal, at the end of the day. The dose needs to be titrated further depending on clinical response, as indicated below under 'Titration'. Dosages that provide up to 30% more levodopa per day may be necessary.

A guide for substitution of 'Sinemet CR' treatment for conventional levodopa/decarboxylase inhibitor combinations is shown in the table below:

Guideline for Conversion from 'Sinemet' to 'Sinemet CR'

'Sinemet'

Daily Dosage

Levodopa (mg)

'Sinemet CR'

Daily Dosage

Levodopa (mg)

 

 

Dosage Regimen

300 - 400

400

1 Tablet 2 x daily

500 - 600

600

1 Tablet 3 x daily

700 - 800

800

4 Tablets in 3 or more divided doses

900 - 1000

1000

5 Tablets in 3 or more divided doses

1100 - 1200

1200

6 Tablets in 3 or more divided doses

1300 - 1400

1400

7 Tablets in 3 or more divided doses

1500 - 1600

1600

8 Tablets in 3 or more divided doses

'Half Sinemet CR' is available to facilitate titration when 100 mg steps are required.

Patients currently treated with levodopa alone

Levodopa must be discontinued at least eight hours before therapy with 'Sinemet CR' is started. In patients with mild to moderate disease, the initial recommended dose is one tablet of 'Sinemet CR' twice daily.

Patients not receiving levodopa

In patients with mild to moderate disease, the initial recommended dose is one tablet of 'Sinemet CR' twice daily. Initial dosages should not exceed 600 mg per day of levodopa, nor be given at intervals of less than six hours.

Titration

Following initiation of therapy, doses and dosing intervals may be increased or decreased, depending upon therapeutic response. Most patients have been adequately treated with two to eight tablets per day of 'Sinemet CR' administered as divided doses at intervals ranging from four to twelve hours during the waking day. Higher doses (up to 12 tablets) and shorter intervals (less than four hours) have been used, but are not usually recommended.

When doses of 'Sinemet CR' are given at intervals of less than four hours, or if the divided doses are not equal, it is recommended that the smaller doses be given at the end of the day. In some patients the onset of effect of the first morning dose may be delayed for up to one hour compared with the response usually obtained from the first morning dose of 'Sinemet'.

An interval of at least three days between dosage adjustments is recommended.

Maintenance

Because Parkinson's disease is progressive, periodic clinical evaluations are recommended and adjustment of the dosage regimen of 'Sinemet CR' or 'Half Sinemet CR' may be required.

Addition of other antiparkinson medication

Anticholinergic agents, dopamine agonists and amantadine can be given with 'Sinemet CR' or 'Half Sinemet CR'. Dosage adjustment of 'Sinemet CR' or 'Half Sinemet CR' may be necessary when these agents are added to an existing treatment regimen for 'Sinemet CR' or 'Half Sinemet CR'.

Interruption of therapy

Patients should be observed carefully if abrupt reduction or discontinuation of 'Sinemet CR' or 'Half Sinemet CR' is required, especially if the patient is receiving antipsychotics (see 4.4 'Special warnings and precautions for use').

Use in Children

Safety and effectiveness of 'Sinemet CR' or 'Half Sinemet CR' in infants and children have not been established, and its use in patients below the age of 18 is not recommended.

4.3 Contraindications

'Sinemet CR' or 'Half Sinemet CR' should not be given when administration of a sympathomimetic amine is contraindicated.

Non-selective monoamine oxidase (MAO) inhibitors are contraindicated for use with 'Sinemet CR' or 'Half Sinemet CR'. These inhibitors must be discontinued at least two weeks prior to initiating therapy with 'Sinemet CR' or 'Half Sinemet CR'. 'Sinemet CR' or 'Half Sinemet CR' may be administered concomitantly with the manufacturer's recommended dose of an MAO inhibitor with selectivity for MAO type B (e.g. selegiline hydrochloride) (See 4.5 'Interactions with other medicinal products and other forms of interaction').

'Sinemet CR' or 'Half Sinemet CR' is contraindicated in patients with known hypersensitivity to any component of this medication, and in patients with narrow-angle glaucoma.

Because levodopa may activate a malignant melanoma, 'Sinemet CR' or 'Half Sinemet CR' should not be used in patients with suspicious undiagnosed skin lesions or a history of melanoma.

Use in patients with severe psychoses.

4.4 Special warnings and precautions for use

When patients are receiving levodopa monotherapy, levodopa must be discontinued at least eight hours before therapy with 'Sinemet CR' or 'Half Sinemet CR' is started (at least 12 hours if slow-release levodopa has been administered).

Dyskinesias may occur in patients previously treated with levodopa alone because carbidopa permits more levodopa to reach the brain and, thus, more dopamine to be formed. The occurrence of dyskinesias may require dosage reduction.

'Sinemet CR' and 'Half Sinemet CR' are not recommended for the treatment of drug-induced extrapyramidal reactions or for the treatment of Huntingdon's chorea.

Based on the pharmacokinetic profile of 'Sinemet CR' the onset of effect in patients with early morning dyskinesias may be slower than with conventional 'Sinemet'. The incidence of dyskinesias is slightly higher during treatment with 'Sinemet CR' than with conventional 'Sinemet' (16.5% vs 12.2%) in advanced patients with motor fluctuations.

'Sinemet CR' or 'Half Sinemet CR' should be administered cautiously to patients with severe cardiovascular or pulmonary disease, bronchial asthma, renal, hepatic or endocrine disease, or with a history of peptic ulcer disease or of convulsions.

Care should be exercised in administering 'Sinemet CR' or 'Half Sinemet CR' to patients with a history of recent myocardial infarction who have residual atrial, nodal, or ventricular arrhythmia. In such patients, cardiac function should be monitored with particular care during the period of initial dosage administration and titration.

Levodopa has been associated with somnolence and episodes of sudden sleep onset. Sudden onset of sleep during daily activities, in some cases without awareness or warning signs, has been reported very rarely. Patients must be informed of this and advised to exercise caution while driving or operating machines during treatment with levodopa. Patients who have experienced somnolence and/or an episode of sudden sleep onset must refrain from driving or operating machines. Furthermore a reduction of dosage or termination of therapy may be considered.

As with levodopa, 'Sinemet CR' or 'Half Sinemet CR' may cause involuntary movements and mental disturbances. Patients with a history of severe involuntary movements or psychotic episodes when treated with levodopa alone or levodopa/decarboxylase inhibitor combination should be observed carefully when 'Sinemet CR' or 'Half Sinemet CR' is substituted. These reactions are thought to be due to increased brain dopamine following administration of levodopa and use of 'Sinemet CR' or 'Half Sinemet CR' may cause recurrence. Dosage reduction may be required. All patients should be observed carefully for the development of depression with concomitant suicidal tendencies. Patients with past or current psychoses should be treated with caution.

Impulse control disorders

Patients should be regularly monitored for the development of impulse control disorders. Patients and carers should be made aware that behavioural symptoms of impulse control disorders including pathological gambling, increased libido, hypersexuality, compulsive spending or buying, binge eating and compulsive eating can occur in patients treated with dopamine agonists and/or other dopaminergic treatments containing levodopa including Sinemet. Review of treatment is recommended if such symptoms develop.

A symptom complex resembling the neuroleptic malignant syndrome including muscular rigidity, elevated body temperature, mental changes, and increased serum creatine phosphokinase has been reported when antiparkinsonian agents were withdrawn abruptly. Therefore, patients should be observed carefully when the dosage of carbidopa-levodopa combinations is reduced abruptly or discontinued, especially if the patient is receiving antipsychotics.

Patients with chronic wide-angle glaucoma may be treated cautiously with 'Sinemet CR' or 'Half Sinemet CR', provided the intraocular pressure is well controlled and the patient monitored carefully for changes in intraocular pressure during therapy.

Periodic evaluations of hepatic, haematopoietic, cardiovascular and renal function are recommended during extended therapy.

If general anaesthesia is required, 'Sinemet CR' or 'Half Sinemet CR' may be continued as long as the patient is permitted to take oral medication. If therapy is interrupted temporarily, the usual dosage should be administered as soon as the patient is able to take oral medicine.

Epidemiological studies have shown that patients with Parkinson's disease have a higher risk of developing melanoma than the general population (approximately 2-6 fold higher). It is unclear whether the increased risk observed was due to Parkinson's disease, or other factors such as drugs used to treat Parkinson's disease. Therefore patients and providers are advised to monitor for melanomas on a regular basis when using 'Sinemet CR' for any indication. Ideally, periodic skin examinations should be performed by appropriately qualified individuals (e.g., dermatologists).

Laboratory Tests

Abnormalities in various laboratory tests have occurred with carbidopa-levodopa preparations and may occur with 'Sinemet CR' or 'Half Sinemet CR'. These include elevations of liver function tests such as alkaline phosphatase, SGOT (AST), SGPT (ALT), LDH, bilirubin, blood urea nitrogen, creatinine, uric acid and positive Coombs' test.

Carbidopa-levodopa preparations may cause a false-positive reaction for urinary ketone bodies when a test tape is used for determination of ketonuria. This reaction will not be altered by boiling the urine specimen. False-negative tests may result with the use of glucose-oxidase methods of testing for glycosuria.

Decreased haemoglobin and haematocrit, elevated serum glucose and white blood cells, bacteria and blood in the urine have been reported with standard 'Sinemet'.

4.5 Interaction with other medicinal products and other forms of interaction

Caution should be exercised when the following drugs are administered concomitantly with 'Sinemet CR' or 'Half Sinemet CR':

Antihypertensive agents

Symptomatic postural hypotension has occurred when levodopa/decarboxylase inhibitor combinations were added to the treatment of patients receiving some antihypertensive drugs. Therefore when therapy with 'Sinemet CR' or 'Half Sinemet CR' is started, dosage adjustment of the antihypertensive drug may be required.

Antidepressants

There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant use of tricyclic antidepressants and carbidopa-levodopa preparations. (For patients receiving monamine oxidase inhibitors, see 4.3 'Contraindications').

Anticholinergics

Anticholinergics may affect the absorption and thus the patient's response.

Iron

Studies demonstrate a decrease in the bioavailability of carbidopa and/or levodopa when it is ingested with ferrous sulphate or ferrous gluconate.

Other drugs

Dopamine D2 receptor antagonists (e.g. phenothiazines, butyrophenones and risperidone) and isoniazid may reduce the therapeutic effects of levodopa. The beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with 'Sinemet CR' or 'Half Sinemet CR' should be observed carefully for loss of therapeutic response.

Use of 'Sinemet CR' with dopamine-depleting agents (e.g., tetrabenazine) or other drugs known to deplete monoamine stores is not recommended.

Concomitant therapy with selegiline and carbidopa-levodopa may be associated with severe orthostatic hypotension not attributable to carbidopa-levodopa alone (See 4.3 'Contraindications').

Since levodopa competes with certain amino acids, the absorption of levodopa may be impaired in some patients on a high protein diet.

The effect of simultaneous administration of antacids with 'Sinemet CR' or 'Half Sinemet CR' on the bioavailability of levodopa has not been studied.

4.6 Pregnancy and lactation

There are insufficient data to evaluate the possible harmfulness of this substance when used in human pregnancy. (See 5.3 'Preclinical Safety Data'). It is not known whether carbidopa is excreted in human milk. In a study of one nursing mother with Parkinson's disease, excretion of levodopa in breast milk was reported. 'Sinemet CR' or 'Half Sinemet CR' should not be given during pregnancy and to nursing mothers.

4.7 Effects on ability to drive and use machines

Individual responses to medication may vary. Certain side effects that have been reported with 'Sinemet CR' may affect some patients' ability to drive or operate machinery. Patients treated with levodopa and presenting with somnolence and/or sudden sleep episodes must be informed to refrain from driving or engaging in activities where impaired alertness may put themselves or other at risk of serious injury or death (e.g. operating machines) until such recurrent episodes and somnolence have resolved (see also section 4.4 'Special warnings and precautions for use').

4.8 Undesirable effects

In controlled clinical trials in patients with moderate to severe motor fluctuations 'Sinemet CR' did not produce side-effects which were unique to the modified-release formulation.

The side-effect reported most frequently was dyskinesia (a form of abnormal involuntary movements). A greater incidence of dyskinesias was seen with 'Sinemet CR' than with 'Sinemet'.

Other side-effects that also were reported frequently (above 2%) were: nausea, hallucinations, confusion, dizziness, chorea and dry mouth.

Side effects occurring less frequently (1-2%) were: dream abnormalities, dystonia, somnolence, insomnia, depression, asthenia, vomiting and anorexia.

Other side effects reported in clinical trials or in post-marketing experience include:

Body as a whole: chest pain, syncope.

Cardiovascular: palpitation, orthostatic effects including hypotensive episodes.

Gastro-intestinal: constipation, diarrhoea, dyspepsia, gastro-intestinal pain, dark saliva.

Hypersensitivity: angioedema, urticaria, pruritus.

Metabolic: weight loss.

Nervous System/Psychiatric: neuroleptic malignant syndrome (see 4.3 'Contraindications'), agitation, anxiety, decreased mental acuity, paraesthesia, disorientation, fatigue, headache, extrapyramidal and movement disorders, falling, gait abnormalities, muscle cramps, on-off phenomenon, increased libido, psychotic episodes including delusions and paranoid ideation. Levodopa is associated with somnolence and has been associated very rarely with excessive daytime somnolence and sudden sleep onset episodes.

Respiratory: dyspnoea

Skin: flushing, alopecia, rash, dark sweat.

Special Senses: blurred vision.

Urogenital: dark urine.

Other side effects that have been reported with levodopa or levodopa/carbidopa combinations and may be potential side-effects with 'Sinemet CR' are listed below:

Cardiovascular: cardiac irregularities, hypertension, phlebitis.

Gastro-intestinal: bitter taste, sialorrhoea, dysphagia, bruxism, hiccups, gastro-intestinal bleeding, flatulence, burning sensation of tongue, development of duodenal ulcer.

Haematologic: leucopenia, haemolytic and non-haemolytic anaemia, thrombocytopenia, agranulocytosis.

Nervous system/Psychiatric: ataxia, numbness, increased hand tremor, muscle twitching, blepharospasm, trismus, activation of latent Horner's syndrome, euphoria, and dementia, depression with suicidal tendencies.

Impulse control disorders

Pathological gambling, increased libido, hypersexuality, compulsive spending or buying, binge eating and compulsive eating can occur in patients treated with dopamine agonists and/or other dopaminergic treatments containing levodopa including Sinemet CR (see section 4.4. 'Special warnings and precautions for use')

Skin: increased sweating.

Special senses: diplopia, dilated pupils, oculogyric crises.

Urogenital: urinary retention, urinary incontinence, priapism.

Miscellaneous: weight gain, oedema, weakness, faintness, hoarseness, malaise, hot flashes, sense of stimulation, bizarre breathing patterns, malignant melanoma (see 4.3 Contraindications), Henoch-Schonlein purpura.

Convulsions have occurred; however, a causal relationship with levodopa or levodopa/carbidopa combinations has not been established.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.

4.9 Overdose

Management of acute overdosage with 'Sinemet CR' or 'Half Sinemet CR' is basically the same as management of acute overdosage with levodopa; however, pyridoxine is not effective in reversing the actions of 'Sinemet CR' or 'Half Sinemet CR'.

Electrocardiographic monitoring should be instituted and the patient observed carefully for the development of arrhythmias; if required, appropriate antiarrhythmic therapy should be given. The possibility that the patient may have taken other drugs as well as 'Sinemet CR' or 'Half Sinemet CR' should be taken into consideration. To date, no experience has been reported with dialysis; hence, its value in overdosage is not known.

5. Pharmacological properties
5.1 Pharmacodynamic properties

'Sinemet CR' and 'Half Sinemet CR' are a combination of carbidopa, an aromatic amino acid decarboxylase inhibitor, and levodopa, the metabolic precursor of dopamine, in a polymer-based controlled-release tablet formulation, for use in the treatment of Parkinson's disease. 'Sinemet CR' and 'Half Sinemet CR' are particularly useful to reduce 'off' time in patients treated previously with a conventional levodopa/decarboxylase inhibitor combination who have had dyskinesias and motor fluctuations.

Patients with Parkinson's disease treated with preparations containing levodopa may develop motor fluctuations characterised by end-of-dose failure, peak dose dyskinesia, and akinesia. The advanced form of motor fluctuations ('on-off' phenomenon) is characterised by unpredictable swings from mobility to immobility. Although the causes of the motor fluctuations are not completely understood, it has been demonstrated that they can be attenuated by treatment regimens that produce steady plasma levels of levodopa.

Levodopa relieves the symptoms of Parkinson's disease by being decarboxylated to dopamine in the brain. Carbidopa, which does not cross the blood-brain barrier, inhibits only the extracerebral decarboxylation of levodopa, making more levodopa available for transport to the brain and subsequent conversion to dopamine. This normally obviates the necessity for large doses of levodopa at frequent intervals. The lower dosage reduces or may help eliminate gastro-intestinal and cardiovascular side-effects, especially those which are attributed to dopamine being formed in extracerebral tissues.

'Sinemet CR' and 'Half Sinemet CR' are designed to release their active ingredients over a four-six hour period. With this formulation there is less variation in plasma levodopa levels and the peak plasma level is 60% lower than with conventional 'Sinemet', as established in healthy volunteers.

In clinical trials, patients with motor fluctuations experienced reduced 'off'-time with 'Sinemet CR' when compared with 'Sinemet'. The reduction of the 'off'-time is rather small (about 10%) and the incidence of dyskinesias increases slightly after administration of 'Sinemet CR' compared to standard 'Sinemet'. Global ratings of improvement and activities of daily living in the 'on' and 'off' state, as assessed by both patient and physician, were better during therapy with 'Sinemet CR' than with 'Sinemet'. Patients considered 'Sinemet CR' to be more helpful for their clinical fluctuations, and preferred it over 'Sinemet'. In patients without motor fluctuations, 'Sinemet CR' under controlled conditions, provided the same therapeutic benefit with less frequent dosing than with 'Sinemet'. Generally, there was no further improvement of other symptoms of Parkinson's disease.

5.2 Pharmacokinetic properties

The pharmacokinetics of levodopa following administration of 'Sinemet CR' were studied in young and elderly healthy volunteers. The mean time to peak plasma levodopa level after 'Sinemet CR' was approximately two hours compared to 0.75 hours with 'Sinemet'. The mean peak plasma levodopa levels were 60% lower with 'Sinemet CR' than with 'Sinemet'. The in vivo absorption of levodopa following administration of 'Sinemet CR' was continuous for 4 to 6 hours. In these studies, as with patients, plasma levodopa concentrations fluctuated in a narrower range than with 'Sinemet'. Because the bioavailability of levodopa from 'Sinemet CR' relative to 'Sinemet' is approximately 70%, the daily dosage of levodopa in the controlled release formulation will usually be higher than with conventional formulations. There was no evidence that 'Sinemet CR' released its ingredients in a rapid or uncontrolled fashion.

The pharmacokinetics of levodopa following administration of 'Half Sinemet CR' were studied in patients with Parkinson's disease. Chronic three month, open-label, twice daily dosing with 'Half Sinemet CR' (range: 50 mg carbidopa, 200 mg levodopa up to 150 mg carbidopa, 600 mg levodopa per day) did not result in accumulation of plasma levodopa. The dose-adjusted bioavailability for one 'Half Sinemet CR' tablet was equivalent to that for one 'Sinemet CR' tablet. The mean peak concentration of levodopa following administration of one 'Half Sinemet CR' tablet was greater than 50% of that following one 'Sinemet CR' tablet. Mean time-to-peak plasma levels may be slightly less for 'Half Sinemet CR' than for 'Sinemet CR'.

It is not known whether or not or to what extent the absorption is influenced by a protein rich diet. The bioavailability may be influenced by drugs which affect the gastro-intestinal propulsion.

5.3 Preclinical safety data

The medicine has appeared harmful in animal trials (visceral and skeletal malformations in rabbits). For reproductive toxicity, see section 4.6 'Pregnancy and lactation'.

6. Pharmaceutical particulars
6.1 List of excipients

Hydroxypropylcellulose

Magnesium Stearate

Poly (Vinyl Acetate-Crotonic Acid) Copolymer

Quinoline Yellow 10 Aluminium Lake E104 (Sinemet CR only)

Red Iron Oxide E172

6.2 Incompatibilities

Not applicable

6.3 Shelf life

36 months

6.4 Special precautions for storage

Do not store above 30°C. Store in the original package in order to protect from light.

6.5 Nature and contents of container

Amber glass bottles or HDPE bottles in packs of 100, 84, or 56 tablets.

All aluminium blister pack of 60 tablets.

6.6 Special precautions for disposal and other handling

Not applicable.

7. Marketing authorisation holder

Merck Sharp & Dohme Limited

Hertford Road, Hoddesdon, Hertfordshire, EN11 9BU, UK.

8. Marketing authorisation number(s)

Sinemet CR 50 mg/200 mg Prolonged-Release Tablets

PL 00025/0269

Half Sinemet CR 25 mg/100 mg Prolonged-Release Tablets

PL 00025/0287

9. Date of first authorisation/renewal of the authorisation

Sinemet CR 50 mg/200 mg Prolonged-Release Tablets: 5 September 1991/Renewed 16 April 2008

Half Sinemet CR 25 mg/100 mg Prolonged-Release Tablets: 7 October 1992/Renewed 16 April 2008

10. Date of revision of the text

24 September 2015

Legal category

POM

© Merck Sharp & Dohme Limited 2015. All rights reserved.

SPC.SEMCR.15.UK.4620.IB-G

Company contact details

Merck Sharp & Dohme Limited

Company image
Address

Hertford Road, Hoddesdon, Hertfordshire, EN11 9BU

Fax

+44 (0)1992 479 292

Stock Availability

Call MSD customer services on 01992 452094

Telephone

+44 (0)1992 467 272

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Active ingredients

carbidopa, levodopa

Legal categories

POM - Prescription Only Medicine

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