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Hirudoid Cream

Last Updated on eMC 15-Apr-2015 View changes  | Genus Pharmaceuticals Contact details

1. Name of the medicinal product

Hirudoid Cream

2. Qualitative and quantitative composition

Heparinoid 0.3% wlw (Equivalent to 25 000 Units per 100 g cream).

3. Pharmaceutical form

Topical cream.

4. Clinical particulars
4.1 Therapeutic indications

Hirudoid is indicated for the treatment of superficial thrombophlebitis and the soothing relief of superficial bruising and haematoma.

4.2 Posology and method of administration

Adults, the elderly and children over 5 years of age:

Two to six inches (5-15 cm) to be applied up to four times daily to the affected area and gently massaged into the skin.

4.3 Contraindications

Not to be used on large areas of skin, broken skin, sensitive areas of skin or mucous membranes. Not to be used in individuals with a known sensitivity to any active or inactive component of the formulation. Not to be used in children under 5 years of age.

4.4 Special warnings and precautions for use

For external use only. If symptoms persist or worsen, seek medical advice. Do not exceed the stated dose.

4.5 Interaction with other medicinal products and other forms of interaction

None known.

4.6 Pregnancy and lactation

There is no evidence to suggest that Hirudoid should not be used during pregnancy and lactation.

4.7 Effects on ability to drive and use machines


4.8 Undesirable effects

None known.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard

4.9 Overdose

In the absence of any reports of the accidental ingestion of Hirudoid, no specific advice is available. General supportive measures may be appropriate.

5. Pharmacological properties
5.1 Pharmacodynamic properties

Heparinoid is recognised as having: a weak inhibitory effect on PGE2 synthesis and an indirect effect on LTB4 production (based on in vitro studies), anti-coagulant activity (as a heparinoid), thrombolytic activity (through potentiation of urokinase activity), anti-exudatory activity (through inhibition of hyaluronidase).

5.2 Pharmacokinetic properties

Radiochemical studies of absorption following cutaneous application of heparinoid (mucopolysaccharide polysulphate) have shown that between 0.3 and 4% of the mucopolysaccharide administered is absorbed by various tissues (other than the treated area) within the first 8 hours. Typically between 1.7% and 4.6% will be absorbed within 2 to 4 days. Animal studies have also shown that mucopolysaccharide is bound intracellularly within the subcutis. Peak serum concentrations following cutaneous application are below the threshold of physiological relevance for coagulation. Mucopolysaccharide is excreted in the urine partly unchanged and partly as depolymerized, shorter chain length molecules.

5.3 Preclinical safety data

None stated.

6. Pharmaceutical particulars
6.1 List of excipients

Anhydrous eucerine

Emulsifying cetostearyl alcohol type A


Isopropyl alcohol

Methyl parahydroxybenzoate (E218)

Myristyl alcohol

Potassium hydroxide

Propyl parahydroxybenzoate (E216)

Purified water

Stearic acid


6.2 Incompatibilities


6.3 Shelf life

5 years.

6.4 Special precautions for storage

Store below 25°C.

6.5 Nature and contents of container

Lacquered aluminium tubes 14, 40, 50g.

6.6 Special precautions for disposal and other handling

Not applicable.

7. Marketing authorisation holder

Genus Pharmaceuticals Limited

T/A Genus Pharmaceuticals




8. Marketing authorisation number(s)

PL 06831/0175

9. Date of first authorisation/renewal of the authorisation


10. Date of revision of the text


Company contact details

Genus Pharmaceuticals

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Linthwaite, Huddersfield, West Yorkshire, HD7 5QH, UK


+44 (0)1484847301

Medical Information e-mail

+44 (0)1484842217

Medical Information Direct Line

+44 (0)870 851 0207

Customer Care direct line

+44 (0)1484 848200

Out of Hours Telephone

+44 (0)870 851 0207

Before you contact this company: often several companies will market medicines with the same active ingredient. Please check that this is the correct company before contacting them. Why?

Active ingredients


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