Oily Phenol Injection BP 5% w/v
Sterile solution intended for parenteral use
Scleropathy of haemorrhoids
Injected into sub-mucosal layer at the base of the haemorrhoid
2-3 ml of oily phenol injection into the sub-mucosal layer at the base of the pile; Several injections may be given at different sites but not more than a total volume of 10 ml should be used at any one time.
Use of this product is not advised
No alternative dosage schedules have been suggested.
Oily Phenol Injection, BP is contraindicated in patients who are hypersensitive to phenol, nuts and in particular almond oil or any component of the product. It should not be used over large areas, since sufficient amounts may be absorbed to give rise to toxic symptoms. Oily Phenol Injection, BP is also contraindicated in neonates and children.
For submucosal injection only. Not for intrathecal use. Complications of therapy can include local ulceration and sterile abscess formation. These complications may be serious following a misplaced injection (eg prostatic abscess). Care in choosing the correct site of injection is mandatory.
Safety in pregnancy has not been established. The effects on the foetus are unknown, therefore Oily Phenol is not recommended for use during pregnancy.
It is not known whether Oily Phenol is excreted in breast milk. Since safety in infants has not been established, Oily Phenol injection is not recommended for use whilst breast-feeding.
Effects of phenol oily injection are not likely to affect the patient's ability to drive and use machinery.
General disorders and administration site conditions:
Immune system disorders:
Nervous system disorders:
Infections and infestations:
Renal and urinary disorders:
Reproductive system and breast disorders:
The symptoms of overdosage after submucosal injection of Oily Phenol are not known, but are likely to be similar to symptoms observed after excessive exposure to phenol in other preparations. Absorption of phenol after application of dilute phenol solutions to extensive wounds has resulted in abdominal pains, dizziness, methaemoglobinaemia, haemoglobinurea, cyanosis, cardiac arrhythmias, ECG abnormalities, and may result in respiratory failure, circulatory failure, coma and death.
There is no specific antidote for acute phenol overdose. Treatment of overdose is symptomatic and supportive.
Oily phenol injection acts as an analgesic and thrombotic agent by numbimg the sensory nerve endings and precipitating proteins.
Phenol is absorbed from the gastro-intestinal tract and through skin and mucous membranes. It is metabolised to phenylglucoronide and phenylsulphate and small amounts are oxidised to catechol and quinol which are mainly conjugated. The metabolites are excreted in the urine; on oxidation to quinones they may tint the urine green.
Incompatible with alkaline salts, acetanilide, phenazone, piperazine, quinine salts, phenacetin and iron salts. Phenol coagulates albumin and gelatinises collodion.
5 ml neutral glass (type 1) ampoules supplied in cartons of 10
UCB Pharma Limited
208 Bath Road
20 March 1987 / 15 October 1997