|Adverse drug reactions are typical of full opioid agonists. Tolerance and dependence may occur (see Tolerance and Dependence, below). Constipation may be prevented with an appropriate laxative. If nausea or vomiting are troublesome, oxycodone may be combined with an antiemetic. The adverse drug reactions seen whilst being treated with oxycodone were:|
Endocrine disorders: Uncommon (>1/1,000, <1/100): syndrome of inappropriate antidiuretic hormone secretion.
Metabolism and nutrition disorders:Common (>1/100, <1/10): anorexiaUncommon (>1/1,000, <1/100): dehydration, weight change, peripheral oedema, oedema, thirst.
Psychiatric disorders (see tolerance and dependence below):Common (>1/100, <1/10): abnormal dreams, anxiety, confusion, insomnia, nervousness, abnormal thinking.Uncommon (>1/1,000, <1/100): libido decreased, depression, hallucinations, depersonalisation, euphoria, mood changes, agitation, emotional lability.
Nervous system disorders:Very common (>1/10): somnolence, dizziness.Common (>1/100, <1/10): faintness, asthenia, headache.Uncommon (>1/1,000, <1/100): abnormal gait, amnesia, hyperkinesia, hypertonia, hypoaesthesia, hypotonia, speech disorder, stupor, tremor, twitching, vertigo, epileptic seizures, paraesthesia, withdrawal syndrome, malaise, muscle contractions involuntary.
Eye disorders:Uncommon (>1/1,000, <1/100): lacrimation disorder, miosis, abnormal vision.
Ear and labyrinth disorders:Uncommon (>1/1,000, <1/100): tinnitus.
Cardiac disorders:Common (>1/100, <1/10): Orthostatic hypotension.Uncommon (>1/1,000, <1/100): palpitations (in the context of withdrawal syndrome), hypotension, syncope.
Vascular disorders:Uncommon (>1/1,00, < 1/100): vasodilation.
Respiratory, thoracic and mediastinal disorders:Common (>1/100, <1/10): dyspnoea, bronchospasm.Uncommon >1/1,000, <1/100): rhinitis, epistaxis, hiccup, voice alteration, respiratory depression.
Gastrointestinal disorders:Very common (>1/10): constipation, nausea, vomiting.Common (>1/100, <1/10): abdominal pain, anorexia, diarrhoea, dry mouth, dyspepsia, Uncommon (>1/1,000, <1/100): dysphagia, flatulence, gastritis, mouth ulceration, eructation, ileus, stomatitis, biliary spasm, gastrointestinal disorders, taste perversion.
Skin and subcutaneous tissue disorders:Very common (>1/10): pruritus.Common (>1/100, <1/10): rash, sweating.Uncommon (>1/1,000, <1/100): dry skin, urticaria.
Renal and urinary disorders:Common (>1/100, <1/10): urinary disorders.Uncommon (>1/1,000, <1/100): urinary retention, ureteral spasm.
Reproductive system and breast disorders:Uncommon (>1/1,000, <1/100): impotence, amenorrhoea.
General disorders and administration site conditions:Common (>1/100, <1/10): fever, chills.Uncommon >1/1,000, <1/100): chest pain, allergic reaction, anaphylactic reaction, anaphylactoid reaction, drug dependence.Tolerance and Dependence:The patient may develop tolerance to the drug with chronic use and require progressively higher doses to maintain pain control. Prolonged use of Oxycodone injection may lead to physical dependence and a withdrawal syndrome may occur upon abrupt cessation of therapy. When a patient no longer requires therapy with oxycodone, it may be advisable to taper the dose gradually to prevent symptoms of withdrawal. The opioid abstinence or withdrawal syndrome is characterised by some or all of the following: restlessness, lacrimation, rhinorrhoea, yawning, perspiration, chills, myalgia and mydriasis. Other symptoms also may develop, including: irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhoea, or increased blood pressure, respiratory rate or heart rate.The development of psychological dependence (addiction) to opioid analgesics in properly managed patients with pain has been reported to be rare. However, data are not available to establish the true incidence of psychological dependence (addiction) in chronic pain patients. Oxycodone injection should be used with particular care in patients with a history of alcohol and drug abuse.