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Aknemycin Plus

Last Updated on eMC 11-Oct-2013 View changes  | Almirall Limited Contact details

The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged.

Please click on the link to the left to view the PIL in PDF format.

Text only version for the visually impaired
Below is a text only representation of the Patient Information leaflet. The original may contain images or tables and can be viewed in PDF format using the link to the left. This PIL may be available from the RNIB in large print, Braille or audio CD. For further information please call the RNIB Medicine Leaflet line on 0800 198 5000. The product code(s) for this leaflet is/are: PL33016/0007.

Aknemycin Plus


Aknemycin® Plus

Erythromycin Ph Eur 4.0% w/w and Tretinoin Ph Eur 0.025% w/w


Read all of this leaflet carefully before you start using this medicine.

  • Keep this leaflet. You may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any of the side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

What is in this leaflet:

1. What Aknemycin Plus is and what it is used for
2. What you need to know before you use Aknemycin Plus
3. How to use Aknemycin Plus
4. Possible side effects
5. How to store Aknemycin Plus
6. Contents of the pack and other information


Aknemycin Plus is a treatment for acne which is applied to the skin.

Aknemycin Plus is a solution and contains Erythromycin and Tretinoin as active ingredients.

Erythromycin is an antibiotic which kills the germs found in acne and reduces the inflammation of your skin.

Tretinoin encourages the layer of dead and hardened skin cells that form on the skin surface to peel off. At the same time, it clears the blackheads which block your skin pores and cause spots to form. Once the pore is unblocked, sebum can escape so that germ activity is limited. Aknemycin Plus also helps dissolve away the excess oil in your skin.


Do not use Aknemycin Plus

  • if you are allergic (hypersensitive) to Erythromycin, Tretinoin or any of the other ingredients of Aknemycin Plus (listed in section 6).
  • if you are suffering from acute eczema, rosacea (a skin disease which affects the face and is characterised by redness, pimples and peeling) or acute inflammatory conditions of the skin, especially around the mouth.
  • if your skin is sunburnt.
  • if you are using any other medication on your skin which may lead to skin irritation e.g. an exfoliator.
  • if you or a member of your family have ever suffered from skin tumours called Cutaneous Epithelioma.

If the above apply to you, talk to your doctor before using this medication.

Warnings and precautions

  • when applying Aknemycin Plus to the face do not let the solution touch your eyes. If by mistake it does, rinse your eyes thoroughly with cold water.
  • take care that the solution does not build up in creases in the skin.
  • if you have to have an X-ray, remove all traces of Aknemycin Plus from the area to be X-rayed.
  • if the solution gets on to your fingers you should wash them thoroughly.
  • during treatment with Aknemycin Plus your skin may become more sensitive to UV light therefore, do not sunbathe, use sunbeds or sunlamps.
  • do not apply the solution before swimming.

Other medicines and Aknemycin Plus

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Pregnancy, breast-feeding and fertility

Do not use Aknemycin Plus when you are pregnant, thinking of becoming pregnant or when you are breast-feeding.

Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines

There are no effects on the ability to drive and use machines when this medication is used.


Always use Aknemycin Plus exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

  • The container has an applicator which allows a simple, hygienic and economic application.
  • Before each use press the top of the screw cap on to the foam pad until you “feel” a click, then invert the bottle so that the solution wets the applicator pad, then wipe the applicator over the affected skin areas.

Normally you should apply Aknemycin Plus once or twice daily as advised by your doctor. After use the applicator will close again automatically.

Duration of treatment

Carry on using Aknemycin Plus for as long as your doctor tells you.

  • The length of time depends on the condition of your skin but this will normally be between 9 and 12 weeks. It is important that you use Aknemycin Plus regularly.
  • There may not be any improvement in your skin condition for several weeks after starting the treatment with Aknemycin Plus.

If you use more Aknemycin Plus than you should

Skin irritation like reddening, drying and discomfort may occur. Reduce the frequency of application if you experience skin irritation or contact your doctor.

If you forget to use Aknemycin Plus

If you forgot to use Aknemycin Plus at the usual time, use it as soon as you remember. Do not apply twice the amount to make up for forgetting to use Aknemycin Plus but carry on as before.

If you have any further questions on the use of this product, ask your doctor or pharmacist.


Like all medicines, Aknemycin Plus can cause side effects, although not everybody gets them.

For example, when you first use Aknemycin Plus your skin problem may seem to get worse. This is a sign that the medicine is beginning to act. However this should soon pass and you will then see an improvement.

Rarely, the skin can be irritated by Aknemycin Plus and you may have a sore, dry or burnt feeling or see peeling. In very rare cases these symptoms may also be an expression of an allergic reaction. If this happens, see your doctor.

Rarely, the skin may become darker or lighter in colour. People with dark skin may see a lightening of their skin where Aknemycin Plus has been used. This is temporary. Your skin will go back to its usual colour when you stop using Aknemycin Plus.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.


Keep out of the reach and sight of children.

Aknemycin Plus should be kept in the outer carton to protect from direct sunlight.

Do not store above 30°C.

Do not use Aknemycin Plus after the expiry date which is stated on the carton after “EXP”. The expiry date refers to the last day of that month.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.


What Aknemycin Plus contains

The active substances are Erythromycin Ph Eur 4.0% w/w and Tretinoin Ph Eur 0.025% w/w

The other ingredients are ethanol, glycerol 85% and copolyvidone.

What Aknemycin Plus looks like and contents of the pack

Aknemycin Plus is a clear solution.

Aknemycin Plus is available in a 25 ml bottle and 50 ml pack (2x25 ml).

Not all pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

Almirall Hermal GmbH
Scholtzstrasse 3
21465 Reinbek

This leaflet was last revised in 08/2013.

00000000 / GB / 0713

Company contact details

Almirall Limited

Company image

1 The Square, Stockley Park, Uxbridge, Middlesex, UB11 1TD, UK

Medical Information Direct Line

0800 0087399

Customer Care direct line

+44 (0) 207 160 2500


+44 (0) 207 160 2500

Medical Information e-mail

Before you contact this company: often several companies will market medicines with the same active ingredient. Please check that this is the correct company before contacting them. Why?

Active ingredients

erythromycin, tretinoin

Legal categories

POM - Prescription Only Medicine

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