| CONDITION
| | ADULTS' DOSAGE (INCLUDING ELDERLY)
| CHILDREN'S DOSAGE (< 40 kg)
| NOTES
|
| Dental procedures: prophylaxis for patients undergoing extraction, scaling or surgery involving gingival tissues and who have not received a penicillin in the previous month.
(N.B. Patients with prosthetic heart valves should be referred to hospital - see below).
| Patient not having general anaesthetic.
| 3 g 'Amoxil' orally, 1 hour before procedure. A second dose may be given 6 hours later, if considered necessary.
| 50 mg amoxicillin/kg body weight given as a single dose one hour preceding the surgical procedure
| Note 1. If prophylaxis with 'Amoxil' is given twice within one month, emergence of resistant streptococci is unlikely to be a problem. Alternative antibiotics are recommended if more frequent prophylaxis is required, or if the patient has received a course of treatment with a penicillin during the previous month.
Note 2
To minimise pain on injection, 'Amoxil' may be given as two injections of 500 mg dissolved in sterile 1% lidocaine solution (see Administration).
|
| Patient having general anaesthetic: if oral antibiotics considered to be appropriate.
| Initially 3 g 'Amoxil' orally 4 hours prior to anaesthesia, followed by 3 g orally (or 1 g IV or IM if oral dose not tolerated) as soon as possible after the operation.
|
| Patient having general anaesthetic: if oral antibiotics not appropriate.
| 1 g 'Amoxil' IV or IM immediately before induction; with 500 mg orally, 6 hours later.
|
| Dental procedures: patients for whom referral to hospital is recommended:
a) Patients to be given a general anaesthetic who have been given a penicillin in the previous month.
b) Patients to be given a general anaesthetic who have a prosthetic heart valve.
c) Patients who have had one or more attacks of endocarditis.
| Initially: 1 g 'Amoxil' IV or IM with 120 mg gentamicin IV or IM immediately prior to anaesthesia (if given) or 15 minutes prior to dental procedure.
Followed by (6 hours later): 500 mg 'Amoxil' orally.
| 50 mg amoxicillin/kg body weight given as a single dose one hour preceding the surgical procedure
| See Note 2.
Note 3. 'Amoxil' and gentamicin should not be mixed in the same syringe.
Note 4. Please consult the appropriate data sheet for full prescribing information on gentamicin.
|
| Genitourinary Surgery or Instrumentation: prophylaxis for patients who have no urinary tract infection and who are to have genito-urinary surgery or instrumentation under general anaesthesia.
In the case of Obstetric and Gynaecological Procedures
and Gastrointestinal Procedures– routine prophylaxis is recommended only for patients with prosthetic heart valves.
| Initially: 1 g 'Amoxil' IV or IM with 120 mg gentamicin IV or IM, immediately before induction.
Followed by (6 hours later): 500 mg 'Amoxil' orally or IV or IM according to clinical condition.
| See Notes 2, 3 and 4 above.
|
| Surgery or Instrumentation of the Upper Respiratory Tract | Patients other than those with prosthetic heart valves.
| 1 g 'Amoxil' IV or IM immediately before induction; 500 mg 'Amoxil' IV or IM 6 hours later.
| 50 mg amoxicillin/kg body weight given as a single dose one hour preceding the surgical procedure
| See Note 2 above.
Note 5. The second dose of 'Amoxil' may be administered orally as 'Amoxil' Syrup SF/DF.
|
| Patients with prosthetic heart valves.
| Initially: 1 g 'Amoxil' IV or IM with 120 mg gentamicin IV or IM, immediately before induction; followed by (6 hours later) 500 mg 'Amoxil' IV or IM.
| 50 mg amoxicillin/kg body weight given as a single dose one hour preceding the surgical procedure
| See Notes 2, 3, 4 and 5 above.
|
