|The following definitions apply to the frequency terminology used hereafter:Very common (≥ 1/10)Common (≥ 1/100, < 1/10)Uncommon (≥ 1/1,000, < 1/100)Rare (≥ 1/10,000, < 1/1,000)Very rare (< 1/10,000)|
Cardiac disorders: Uncommon: AV-conduction disturbances, worsening of pre-existing heart failure, bradycardia.
Vascular disorders: Common: feeling of coldness or numbness in the extremities, hypotension.Uncommon: Orthostatic hypotension.
Metabolism and nutrition disorders: Rare: Increased triglycerides.
Psychiatric disorders:Uncommon: sleep disorders, depression.Rare: nightmares, hallucinations.
Nervous system disorders: Common: dizziness*, headache*.Rare: syncope
Eye disorders: Rare: reduced tear flow (to be considered if the patient uses lenses).Very rare: conjunctivitis.
Ear and labyrinth disorders: Rare: hearing disorders.
Respiratory, thoracic and mediastinal disorders: Uncommon: bronchospasm in patients with bronchial asthma or a history of obstructive airways disease.Rare: allergic rhinitis.
Gastrointestinal disorders: Common: gastrointestinal complaints such as nausea, vomiting, diarrhoea, constipation.Hepatobiliary disorders: Rare: increased liver enzymes (ALAT, ASAT), hepatitis.
Skin and subcutaneous tissue disorders: Rare: hypersensitivity reactions (itching, flush, rash).Very rare: beta-blockers may provoke or worsen psoriasis or induce psoriasis-like rash, alopecia.
Musculoskeletal and connective tissue disorders:Uncommon: muscular weakness and cramps.
Reproductive system and breast disorders: Rare: potency disorders.
General disorders:Common: fatigue*.Uncommon: asthenia.*These symptoms especially occur at the beginning of the therapy. They are generally mild and often disappear within 1-2 weeks.