|System Organ Class
||Common (>1/100, <1/10)||Uncommon (>1/1000,<1/100)||Rare (>1/10,000, <1/1000)
||Very rare (≤1/10,0000)
|Blood and the lymphatic system
|| || || ||Blood count changes (leucopenia, thrombocytopenia) these are usually reversible, agranulocytosis, pancytopenia (sometimes with marrow hypoplasia) or marrow aplasia
|Immune system disorders
|| || ||Hypersensitivity reactions (urticaria, angioneurotic oedema, fever, bronchospasm, hypotension and chest pain).
||Anaphylactic shock. These events have been reported after a single dose.
|| || || ||Reversible mental confusion, depression and hallucinations (especially in the elderly or severely ill)
|Nervous system disorders
|| || || ||Headache (sometimes severe), dizziness and reversible involuntary movement disorders
|| || || ||Reversible blurred vision. There have been reports of blurred vision which is suggestive of a change in accommodation.
|| || || ||As with other H2
receptor antagonists bradycardia, A-V block
|| || || ||Vasculitis
|| ||Abdominal pain, diarrhoea, constipation, nausea (these symptoms mostly improved during continued treatment).
|| ||Acute pancreatitis
|| || ||Transient and reversible changes in liver function tests
||Hepatitis (hepatocellular, hepatocanalicular or mixed) with or without jaundice, these were usually reversible
|Skin and subcutaneous tissue disorders
|| || ||Skin rash
||Erythema multiforme, alopecia
|Musculoskeletal, connective tissue and bone disorders
|| || || ||Musculoskeletal symptoms such as arthralgia, myalgia
|Renal and urinary disorders
|| || ||Elevation of plasma creatinine (usually slight; normalised during continued treatment).
||Acute interstitial nephritis
|Reproductive system and breast disorders
|| || || ||Reversible impotence, breast symptoms and breast conditions (such as gynaecomastia and galactorrhoea).